Abstract:
:The authors investigated the effects of a volatile anesthetic (isoflurane) on the functional properties of a well characterized membrane ion channel (the acetylcholine receptor channel), using the patch clamp electrophysiological method together with local microperfusion of isoflurane. They found that isoflurane causes single acetylcholine receptor channels to "flicker" rapidly between open and closed states, reminiscent of the kinetic pattern induced by local anesthetics. The mean amplitude of currents flowing through open channels was unchanged. Although these observations initially suggested that isoflurane blocks open ion channels, closer analysis of the "isoflurane pattern" revealed features inconsistent with classical open channel block: the duration of bursts of channel openings is shortened, and that of the brief closures within bursts lengthens as the concentration of isoflurane is increased. The authors suggest that isoflurane exerts its characteristic effects on the kinetic properties of acetylcholine receptor channel by an allosteric mechanism. In addition, and apart from their mechanistic significance, these effects may underlie the known potentiation by isoflurane of curariform neuromuscular blockade.
journal_name
Anesthesiologyjournal_title
Anesthesiologyauthors
Brett RS,Dilger JP,Yland KFdoi
10.1097/00000542-198808000-00003subject
Has Abstractpub_date
1988-08-01 00:00:00pages
161-70issue
2eissn
0003-3022issn
1528-1175journal_volume
69pub_type
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