Abstract：
PURPOSE:To evaluate the long-term safety and efficacy of infliximab therapy for refractory uveitis associated with Behçet's disease (BD). METHODS:We prospectively enrolled six patients who failed to respond to conventional immunosuppressive treatment. Infliximab infusions (5 mg/kg) were administered at weeks 0, 2, 6, and then every 8 weeks. The outcome variables were visual acuity, control of inflammation, reduction of macular edema, tapering of immunosuppressive therapy, and adverse effects. RESULTS:The follow-up period ranged from 16 to 36 months (mean +/- SD, 23 +/- 7.4 months). The number of infliximab infusions ranged from 10 to 23 (14 +/- 4.6). By the 2-month follow-up, all patients had achieved remission, the cystoid macular edema had resolved, and visual acuity had improved dramatically. Throughout the follow-up period, three patients remained attack-free. One patient had one relapse, and another patient had two relapses before the scheduled infusions; all three relapses resolved rapidly after the subsequent infusion. One patient developed five relapses, and infusions at 6-week intervals were necessary to achieve sustained remission. At the end of the follow-up period, visual acuity improved in five patients. Concomitant immunosuppressive therapy was substantially reduced. Antinuclear antibodies developed in two patients who received 17 and 23 infusions. No major adverse effects requiring withdrawal of infliximab were observed. CONCLUSION:Infliximab is efficient and safe for long-term treatment of refractory uveitis associated with BD. Repeated infusions are required to maintain long-term remission.
journal_name
Int Ophthalmoljournal_title
International ophthalmologyauthors
Abu El-Asrar AM,Abboud EB,Aldibhi H,Al-Arfaj Adoi
10.1007/s10792-006-9006-9subject
Has Abstractpub_date
2005-06-01 00:00:00pages
83-92issue
3eissn
0165-5701issn
1573-2630journal_volume
26pub_type
杂志文章abstract：UNLABELLED:We examined the immunocytochemical features of after cataract tissue and cataractous lens epithelium prior to cataract surgery and at the time of surgery. METHODS:This study included 23 cases. Antibodies against the following antigens were used: epidermal growth factor (EGF), EGF receptor (EGF-R), fibroblas...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1023/a:1010640118852
更新日期：1999-01-01 00:00:00
abstract：PURPOSE:To evaluate the additional intraocular pressure (IOP) lowering effect of gonioscopy-assisted transluminal trabeculotomy (GATT) to contemporary goniosynechialysis (GSL) in endeavouring to abolish subsequent occlusion after chronic iridotrabecular contact in primary angle closure (PAC) patients. METHODS:A retros...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-020-01676-y
更新日期：2021-01-03 00:00:00
abstract：:Onchocerciasis is a devastating blinding disease caused by the parasite Onchocerca volvulus that infects about 80 million people, causing blindness and visual impairment in 1-2 million people. In hyperendemic areas, more than half of the population will become blind from onchocerciasis before they die. Blindness is th...
journal_title：International ophthalmology
pub_type： 杂志文章,评审
doi：10.1007/BF00158317
更新日期：1990-05-01 00:00:00
abstract：BACKGROUND:Autoenucleation is a severe, rare form of self-mutilation. The majority of cases have been reported in the 15- to 60-year age group, usually in psychiatric patients with a history of depression or schizophrenia, sometimes caused by drug abuse. CASE REPORT:We report a case of left-sided autoenucleation in an...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-008-9222-6
更新日期：2009-08-01 00:00:00
abstract：PURPOSE:To compare sub-tenon steroid plus anti-VEGF injection with anti-VEGF injection solely in the treatment of resistant diabetic macular edema (DME). METHOD:Patients who exhibited insufficient anatomic [over 350 μm central macular thickness (CMT)] and less than 3 lines of visual gain at least six anti-VEGF injecti...
journal_title：International ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10792-018-0977-0
更新日期：2019-07-01 00:00:00
abstract：PURPOSE:To describe a case of scattered toxicity of indocyanine green on the outer retina and retinal pigment epithelium (RPE) after indocyanine green (ICG) assisted membrane peeling for macular pucker. METHODS:A 61-year-old woman was examined by slit-lamp biomicroscopy, fluorescein angiography (FA), indocyanine green...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-007-9112-3
更新日期：2008-04-01 00:00:00
abstract：PURPOSE:To compare the preoperative and postoperative measurements of optical low-coherence reflectometry (OLCR) biometry and assessment of its refractive predictability. METHODS:A total of 114 eyes of 102 patients who underwent cataract treatment were prospectively examined. The axial length (AL), central corneal thi...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-018-0952-9
更新日期：2019-06-01 00:00:00
abstract：PURPOSE:Proliferative vitreoretinopathy (PVR) is characterized by the formation of cellular membranes on the detached retina and also in the vitreous. Glial cells can be found in epiretinal and subretinal membranes from eyes with PVR, proliferative diabetic retinopathy (PDR), idiopathic macular pucker, uveitis and othe...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1023/a:1022509614815
更新日期：2001-01-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00133735
更新日期：1995-01-01 00:00:00
abstract：:Dear editor and readers, this letter is written to make you aware that the original version of this article unfortunately contained a mistake. ...
journal_title：International ophthalmology
pub_type： 杂志文章,已发布勘误
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更新日期：2019-01-01 00:00:00
abstract：PURPOSE:To compare the outcome of penetrating keratoplasty (PKP) and deep anterior lamellar keratoplasty (DALK) in the surgical management of keratoconus (KC). PATIENT AND METHODS:A retrospective review was conducted of the medical records of all patients treated with PKP or DALK for KC at University of Iowa Hospitals...
journal_title：International ophthalmology
pub_type： 杂志文章
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更新日期：2010-12-01 00:00:00
abstract：:We report an unusual case of disseminated cysticercosis having simultaneous intraocular and extraocular involvement. This 21-year-old male presented with recent loss of vision in one eye and history of a single seizure. Examination revealed intravitreal cysticercosis with exudative retinal detachment. Computed tomogra...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-005-8248-2
更新日期：2005-02-01 00:00:00
abstract：:In order to evaluate possible etiological factors and the natural course of 'idiopathic' preretinal fibrosis in young persons, nine consecutive patients with macular pucker diagnosed under the age of 50 years were examined. There were six women and three men with the mean age of 27.2 years (range 15-50) and the mean f...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00202776
更新日期：1987-02-01 00:00:00
abstract：:The purpose of this study was to evaluate the presence of Toxoplasmosis gondii in samples of peripheral blood from patients with varying etiologies of uveitis. Whole blood from patients with different forms of uveitis was tested for the presence of T. gondii using real-time PCR targeting the well-characterized 529 bp ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-016-0221-8
更新日期：2017-02-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章,评审
doi：10.1007/s10792-012-9588-3
更新日期：2012-10-01 00:00:00
abstract：PURPOSE:Ripasudil accelerates aqueous humour drainage along the trabecular meshwork-Schlemm's canal route and has been approved for clinical use in Japan. We retrospectively investigated the efficacy and safety of adding ripasudil to existing treatment regimens to reduce intraocular pressure (IOP) in patients with glau...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-016-0427-9
更新日期：2018-02-01 00:00:00
abstract：:The main visual field indices of Flammer and the analogous ones of Heijl have been compared based on a population of 113 glaucomatous visual fields. It is shown that for the population studied, the differences between the two sets of indices are negligible for Octopus G1 program results and that they may thus be used ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/BF00128955
更新日期：1991-09-01 00:00:00
abstract：PURPOSE:Extemporaneously prepared miconazole eye drops (EPMD) are used by some eye care practitioners to manage keratomycosis in Ghana. This study therefore aimed to determine the efficacy and safety of EPMD using in vitro and in vivo experimental models. METHODS:The minimum inhibitory concentration (MIC) of EPMD was ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-017-0707-z
更新日期：2018-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s10792-021-01707-2
更新日期：2021-01-22 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章
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更新日期：2001-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：1992-09-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-017-0623-2
更新日期：2018-08-01 00:00:00
abstract：:A national study was conducted in children attending six schools for the blind in Malaysia to identify the anatomical site and underlying causes of blindness (BL) and severe visual impairment (SVI), with a view to determine the potentially preventable and treatable causes so that appropriate control measures can be im...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1023/a:1014493228691
更新日期：2001-01-01 00:00:00
abstract：PURPOSE:The aim of this pilot study was to evaluate a new semiautomatic procedure to assess in vivo changes in the crystalline lens and ciliary muscle during accommodation. METHODS:A total of 14 subjects were divided into two groups, young (aged between 20 and 25 years) and adult (aged between 35 and 40 years), and me...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-017-0752-7
更新日期：2018-12-01 00:00:00
abstract：:Myelinated retinal nerve fibers (MRNF) represent an asymptomatic developmental anomaly in which myelin sheaths extend to a group of retinal nerve fibers along their intraocular portion. The additional volume of the myelin sheaths causes displacement of the axons toward the vitreous body. We investigated the effect of ...
journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-016-0207-6
更新日期：2016-12-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-013-9890-8
更新日期：2014-08-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1023/a:1006338013075
更新日期：1998-01-01 00:00:00
abstract：:To evaluate the potential benefit of intraocular pressure (IOP) reduction in normal-tension glaucoma (NTG) patients in South Korea. A retrospective, multi-center analysis of Korean NTG patients with 5-years follow-up, typical glaucomatous optic disc and/or visual field changes and no recorded IOP >21 mmHg. Progression...
journal_title：International ophthalmology
pub_type： 杂志文章,多中心研究
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更新日期：2011-10-01 00:00:00
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journal_title：International ophthalmology
pub_type： 杂志文章
doi：10.1007/s10792-017-0545-z
更新日期：2018-06-01 00:00:00
