Implications of the failure to identify high-risk electrocardiogram findings for the quality of care of patients with acute myocardial infarction: results of the Emergency Department Quality in Myocardial Infarction (EDQMI) study.

Abstract:

BACKGROUND:The impact of misinterpretation of the ECG in patients with acute myocardial infarction (AMI) in the emergency department (ED) setting is not well known. Our goal was to assess the prevalence of the failure to identify high-risk ECG findings in ED patients with AMI and to determine whether this failure is associated with lower-quality care. METHODS AND RESULTS:In a retrospective cohort study of consecutive patients presenting to 5 EDs in California and Colorado from July 1, 2000, through June 30, 2002, with confirmed AMI (n=1684), we determined the frequency of the failure by the treating provider to identify significant ST-segment depressions, ST-segment elevations, or T-wave inversions on the presenting ECG. In multivariable models, we assessed the relationship between missed high-risk ECG findings and evidence-based therapy in the ED after adjustment for patient characteristics and site of care. High-risk ECG findings were not documented in 201 patients (12%). The failure to identify high-risk findings was independently associated with a higher odds of not receiving treatment among ideal candidates for aspirin (odds ratio [OR], 2.13; 95% confidence interval [CI], 1.51 to 2.94), beta-blockers (OR, 1.85; 95% CI, 1.14 to 3.03), and reperfusion therapy (OR, 7.69; 95% CI, 3.57 to 16.67). Among patients with missed high-risk ECG findings, in-hospital mortality was 7.9% compared with 4.9% among those without missed findings (P=0.1). CONCLUSIONS:The failure to identify high-risk ECG findings in patients with AMI results in lower-quality care in the ED. Systematic processes to improve ECG interpretation may have important implications for patient treatment and outcomes.

journal_name

Circulation

journal_title

Circulation

authors

Masoudi FA,Magid DJ,Vinson DR,Tricomi AJ,Lyons EE,Crounse L,Ho PM,Peterson PN,Rumsfeld JS,Emergency Department Quality in Myocardial Infarction Study Investigators.

doi

10.1161/CIRCULATIONAHA.106.623652

subject

Has Abstract

pub_date

2006-10-10 00:00:00

pages

1565-71

issue

15

eissn

0009-7322

issn

1524-4539

pii

CIRCULATIONAHA.106.623652

journal_volume

114

pub_type

杂志文章,多中心研究
  • Effect of activation of the H1 receptor on coronary hemodynamics in man.

    abstract::We evaluated the effects of selective activation of H1 receptors on coronary hemodynamics in 16 patients divided into two groups: group A, 11 patients with atypical angina or valvular heart disease and normal coronary arteries, and group B, five patients with spontaneous angina, four of whom had significant (greater t...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.73.6.1175

    authors: Vigorito C,Poto S,Picotti GB,Triggiani M,Marone G

    更新日期:1986-06-01 00:00:00

  • Tripling survival from sudden cardiac arrest via early defibrillation without traditional education in cardiopulmonary resuscitation.

    abstract:BACKGROUND:Early defibrillation is the most important intervention affecting survival from sudden cardiac arrest (SCA). To improve public access to early defibrillation, we established Piacenza Progetto Vita (PPV), the first system of out-of-hospital early defibrillation by first-responder volunteers. METHODS AND RESU...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.0000028148.62305.69

    authors: Capucci A,Aschieri D,Piepoli MF,Bardy GH,Iconomu E,Arvedi M

    更新日期:2002-08-27 00:00:00

  • Atherosclerosis and late closure of aortocoronary saphenous vein grafts: sequential angiographic studies at 2 weeks, 1 year, 5 to 7 years, and 10 to 12 years after surgery.

    abstract::Sequential control angiographic examinations were performed at 2 weeks, 1 year, 5 to 7 years, and 10 to 12 years after aortocoronary saphenous vein bypass surgery in 82 unselected patients. Graft modifications consisting of wall irregularities and obstructive lesions of various severity and shapes that were found to d...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Campeau L,Enjalbert M,Lespérance J,Vaislic C,Grondin CM,Bourassa MG

    更新日期:1983-09-01 00:00:00

  • Infarct size, myocardial hemorrhage, and recovery of function after mechanical versus pharmacological reperfusion: effects of lytic state and occlusion time.

    abstract:BACKGROUND:Whether myocardial reperfusion obtained with thrombolysis or primary angioplasty is associated with a similar recovery of function and with the same risk of hemorrhagic infarction is unknown. We evaluated the effects of mechanical and pharmacological reperfusion (with or without a plasma lytic state) on infa...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.96.2.659

    authors: Pislaru SV,Barrios L,Stassen T,Jun L,Pislaru C,Van de Werf F

    更新日期:1997-07-15 00:00:00

  • Inducible nitric oxide synthase inhibition of weibel-palade body release in cardiac transplant rejection.

    abstract:BACKGROUND:Inducible nitric oxide synthase (iNOS, or NOS2) reduces the severity of accelerated graft arteriosclerosis (AGA) in transplanted organs, although the precise mechanism is unclear. METHODS AND RESULTS:We transplanted wild-type murine hearts into either wild-type or NOS2-null recipient mice; we then measured ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/hc4401.098471

    authors: Qian Z,Gelzer-Bell R,Yang Sx SX,Cao W,Ohnishi T,Wasowska BA,Hruban RH,Rodriguez ER,Baldwin WM 3rd,Lowenstein CJ

    更新日期:2001-11-06 00:00:00

  • Intrapericardial paclitaxel delivery inhibits neointimal proliferation and promotes arterial enlargement after porcine coronary overstretch.

    abstract:BACKGROUND:Catheter-based intrapericardial (IPC) delivery of therapeutic agents has recently been demonstrated. Paclitaxel is known to inhibit vascular smooth muscle cell proliferation. This study examined the effect of IPC instillation of paclitaxel on neointimal proliferation after balloon overstretch of porcine coro...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.102.13.1575

    authors: Hou D,Rogers PI,Toleikis PM,Hunter W,March KL

    更新日期:2000-09-26 00:00:00

  • A Novel Role of Cyclic Nucleotide Phosphodiesterase 10A in Pathological Cardiac Remodeling and Dysfunction.

    abstract:BACKGROUND:Heart failure is a leading cause of death worldwide. Cyclic nucleotide phosphodiesterases (PDEs), through degradation of cyclic nucleotides, play critical roles in cardiovascular biology and disease. Our preliminary screening studies have revealed PDE10A upregulation in the diseased heart. However, the roles...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.119.042178

    authors: Chen S,Zhang Y,Lighthouse JK,Mickelsen DM,Wu J,Yao P,Small EM,Yan C

    更新日期:2020-01-21 00:00:00

  • Canadian implantable defibrillator study (CIDS) : a randomized trial of the implantable cardioverter defibrillator against amiodarone.

    abstract:BACKGROUND:Patients surviving ventricular fibrillation (VF) or sustained ventricular tachycardia (VT) are at a high risk of death due to a recurrence of arrhythmia. The implantable cardioverter defibrillator (ICD) terminates VT or VF, but it is not known whether this device prolongs life in these patients compared with...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.cir.101.11.1297

    authors: Connolly SJ,Gent M,Roberts RS,Dorian P,Roy D,Sheldon RS,Mitchell LB,Green MS,Klein GJ,O'Brien B

    更新日期:2000-03-21 00:00:00

  • NT-proBNP (N-Terminal pro-B-Type Natriuretic Peptide)-Guided Therapy in Acute Decompensated Heart Failure: PRIMA II Randomized Controlled Trial (Can NT-ProBNP-Guided Therapy During Hospital Admission for Acute Decompensated Heart Failure Reduce Mortality

    abstract:BACKGROUND:The concept of natriuretic peptide guidance has been extensively studied in patients with chronic heart failure (HF), with only limited success. The effect of NT-proBNP (N-terminal probrain natriuretic peptide)-guided therapy in patients with acute decompensated HF using a relative NT-proBNP target has not b...

    journal_title:Circulation

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1161/CIRCULATIONAHA.117.029882

    authors: Stienen S,Salah K,Moons AH,Bakx AL,van Pol P,Kortz RAM,Ferreira JP,Marques I,Schroeder-Tanka JM,Keijer JT,Bayés-Genis A,Tijssen JGP,Pinto YM,Kok WE

    更新日期:2018-04-17 00:00:00

  • Equilibrium contrast cardiovascular magnetic resonance for the measurement of diffuse myocardial fibrosis: preliminary validation in humans.

    abstract:BACKGROUND:Diffuse myocardial fibrosis is a final end point in most cardiac diseases. It is missed by the cardiovascular magnetic resonance (CMR) late gadolinium enhancement technique. Currently, quantifying diffuse myocardial fibrosis requires invasive biopsy, with inherent risk and sampling error. We have developed a...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:10.1161/CIRCULATIONAHA.109.930636

    authors: Flett AS,Hayward MP,Ashworth MT,Hansen MS,Taylor AM,Elliott PM,McGregor C,Moon JC

    更新日期:2010-07-13 00:00:00

  • Improved vascular endothelial function after oral B vitamins: An effect mediated through reduced concentrations of free plasma homocysteine.

    abstract:BACKGROUND:Hyperhomocysteinemia is an independent risk factor for coronary heart disease (CHD). Dietary supplementation with B vitamins lowers plasma homocysteine by up to 30%. However, little is known about the potential beneficial effects of homocysteine lowering on vascular function in patients with CHD. METHODS AN...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.cir.102.20.2479

    authors: Chambers JC,Ueland PM,Obeid OA,Wrigley J,Refsum H,Kooner JS

    更新日期:2000-11-14 00:00:00

  • Microsomal prostaglandin e2 synthase-1 modulates the response to vascular injury.

    abstract:BACKGROUND:Microsomal (m) prostaglandin (PG) E₂ synthase (S)-1 catalyzes the formation of PGE₂ from PGH₂, a cyclooxygenase product that is derived from arachidonic acid. Previous studies in mice suggest that targeting mPGES-1 may be less likely to cause hypertension or thrombosis than cyclooxygenase-2-selective inhibit...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.110.973685

    authors: Wang M,Ihida-Stansbury K,Kothapalli D,Tamby MC,Yu Z,Chen L,Grant G,Cheng Y,Lawson JA,Assoian RK,Jones PL,Fitzgerald GA

    更新日期:2011-02-15 00:00:00

  • Elevated numbers of tissue-factor exposing microparticles correlate with components of the metabolic syndrome in uncomplicated type 2 diabetes mellitus.

    abstract:BACKGROUND:Type 2 diabetes is associated with accelerated atherosclerosis. Because cell-derived microparticles support coagulation and inflammation, they may be involved in atherogenesis. We characterized circulating microparticles both in patients with uncomplicated, well-regulated type 2 diabetes and in healthy subje...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.cir.0000036596.59665.c6

    authors: Diamant M,Nieuwland R,Pablo RF,Sturk A,Smit JW,Radder JK

    更新日期:2002-11-05 00:00:00

  • Effect of Empagliflozin on Left Ventricular Volumes in Patients with Type 2 Diabetes, or Prediabetes, and Heart Failure with Reduced Ejection Fraction (SUGAR-DM-HF).

    abstract:BACKGROUND:Sodium-glucose cotransporter 2 inhibitors reduce the risk of heart failure hospitalization and cardiovascular death in patients with heart failure and reduced ejection fraction (HFrEF). However, their effects on cardiac structure and function in HFrEF are uncertain. METHODS:We designed a multicenter, random...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.120.052186

    authors: Lee MMY,Brooksbank KJM,Wetherall K,Mangion K,Roditi G,Campbell RT,Berry C,Chong V,Coyle L,Docherty KF,Dreisbach JG,Labinjoh C,Lang NN,Lennie V,McConnachie A,Murphy CL,Petrie CJ,Petrie JR,Speirits IA,Sourbron S,Wel

    更新日期:2020-11-13 00:00:00

  • High-resolution, three-dimensional fluorescent imaging reveals multilayer conduction pattern in the atrioventricular node.

    abstract:BACKGROUND:The atrioventricular node (AVN) is the only normal electrical link between the upper and lower chambers of the heart. The AVN modulates transmission of impulses, thus coordinating the contraction of the atria and ventricles. METHODS AND RESULTS:Structural and functional complexity, combined with the absence...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.98.1.54

    authors: Efimov IR,Mazgalev TN

    更新日期:1998-07-07 00:00:00

  • Role of mitochondrial aldehyde dehydrogenase in nitroglycerin-induced vasodilation of coronary and systemic vessels: an intact canine model.

    abstract:BACKGROUND:It has recently been shown that mitochondrial aldehyde dehydrogenase 2 (mtALDH) catalyzes the formation of 1,2-glyceryl dinitrate and nitrite from nitroglycerin (glyceryl trinitrate [GTN]) within mitochondria, leading to production of cGMP and vasorelaxation. However, whether this mechanism operates in the s...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.CIR.0000138105.17864.6B

    authors: Zhang J,Chen Z,Cobb FR,Stamler JS

    更新日期:2004-08-10 00:00:00

  • Psychological and behavioral responses after coronary artery bypass surgery.

    abstract::One hundred consecutive patients who underwent coronary artery bypass surgery at the Columbia-Presbyterian Medical Center from December 1972 through February 1975 were evaluated at surgery and then followed for as long as 4 1/2 years to study their postoperative psychosocial and behavioral course. One patient died dur...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Kornfeld DS,Heller SS,Frank KA,Wilson SN,Malm JR

    更新日期:1982-11-01 00:00:00

  • The Ross procedure: a systematic review and meta-analysis.

    abstract:BACKGROUND:Reports on outcome after the Ross procedure are limited by small study size and show variable durability results. A systematic review of evidence on outcome after the Ross procedure may improve insight into outcome and potential determinants. METHODS AND RESULTS:A systematic review of reports published from...

    journal_title:Circulation

    pub_type: 杂志文章,meta分析,评审

    doi:10.1161/CIRCULATIONAHA.107.726349

    authors: Takkenberg JJ,Klieverik LM,Schoof PH,van Suylen RJ,van Herwerden LA,Zondervan PE,Roos-Hesselink JW,Eijkemans MJ,Yacoub MH,Bogers AJ

    更新日期:2009-01-20 00:00:00

  • Role of thrombin compared with factor Xa in the procoagulant activity of whole blood clots.

    abstract:BACKGROUND:Thrombi are known to induce activation of the coagulation system, which may be a mechanism for progression of thrombosis and its recurrence after thrombolysis. This study was designed to characterize the relative role of thrombin and activated factor X (factor Xa) as mediators of procoagulant activity of who...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.92.4.962

    authors: Prager NA,Abendschein DR,McKenzie CR,Eisenberg PR

    更新日期:1995-08-15 00:00:00

  • Stabilization of atherosclerotic plaques by blockade of macrophage migration inhibitory factor after vascular injury in apolipoprotein E-deficient mice.

    abstract:BACKGROUND:Macrophage migration inhibitory factor (MIF), a cytokine that controls cell-mediated inflammatory responses, is upregulated in atherogenesis; however, its functional contribution to lesion development has not been evaluated. METHODS AND RESULTS:We studied the role of MIF on neointima lesion formation after ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.CIR.0000109201.72441.09

    authors: Schober A,Bernhagen J,Thiele M,Zeiffer U,Knarren S,Roller M,Bucala R,Weber C

    更新日期:2004-01-27 00:00:00

  • Effects of the beta 1-adrenergic receptor partial agonist xamoterol on left ventricular diastolic function. An evaluation after 1-6 years of oral therapy.

    abstract::Acute intravenous administration of the new beta 1-adrenergic receptor partial agonist xamoterol lowers left ventricular end-diastolic pressure and improves the isovolumic indexes of inotropic state and relaxation. To determine if these hemodynamic changes were maintained after prolonged administration, the dose-respo...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Pouleur H,Etienne J,Van Mechelen H,Gurné O,Rousseau MF

    更新日期:1990-02-01 00:00:00

  • Coronary bypass surgery in chronic stable angina.

    abstract::Over the last 20 years, operative mortality has decreased and late survival has improved for patients with chronic stable angina who have coronary artery bypass surgery. However, this favorable trend may not continue because the operation is now extended to elderly and high-risk patients. The most powerful predictors ...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,评审

    doi:

    authors: Gersh BJ,Califf RM,Loop FD,Akins CW,Pryor DB,Takaro TC

    更新日期:1989-06-01 00:00:00

  • Temporal Trends in Percutaneous Coronary Intervention Appropriateness: Insights From the Clinical Outcomes Assessment Program.

    abstract:BACKGROUND:It is unknown whether the appropriate use of percutaneous coronary intervention (PCI) has improved over time and whether trends in PCI appropriateness have been accompanied by changes in the use of PCI. METHODS AND RESULTS:We applied appropriate use criteria to determine the appropriateness of all 51 872 PC...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.114.015156

    authors: Bradley SM,Bohn CM,Malenka DJ,Graham MM,Bryson CL,McCabe JM,Curtis JP,Lambert-Kerzner A,Maynard C

    更新日期:2015-07-07 00:00:00

  • Direct evidence for cytokine involvement in neointimal hyperplasia.

    abstract:BACKGROUND:Tumor necrosis factor-alpha (TNF-alpha) and interleukin 1 (IL-1) are proximal inflammatory cytokines that stimulate expression of adhesion molecules and induce synthesis of other proinflammatory cytokines. In addition, TNF-alpha and IL-1 influence vascular smooth muscle cell migration and proliferation in vi...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.102.14.1697

    authors: Rectenwald JE,Moldawer LL,Huber TS,Seeger JM,Ozaki CK

    更新日期:2000-10-03 00:00:00

  • Pressor response to saralasin (1-sar-8-ala-angiotensin II) bolus injection in hypertensive patients.

    abstract::A 10 mg bolus of the angiotensin blocker saralasin was injected 113 times in 68 subjects with essential or renovascular hypertension. Ninety percent of injections caused a transient increase in blood pressure, which correlated with plasma renin activity (PRA) (r = -0.54); Mean increase at 2 minutes was 21/13.4 mm Hg (...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.57.6.1165

    authors: Waks UA,Maxwell MH,Marks L,Zawada ET,Kaufman JJ

    更新日期:1978-06-01 00:00:00

  • Effects of tissue plasminogen activator and a comparison of early invasive and conservative strategies in unstable angina and non-Q-wave myocardial infarction. Results of the TIMI IIIB Trial. Thrombolysis in Myocardial Ischemia.

    abstract:BACKGROUND:Although coronary thrombosis plays a critical role in the pathogenesis of unstable angina and non-Q-wave myocardial infarction (NQMI), the effects of thrombolytic therapy in these disorders is not clear. Also, the role of routine early coronary arteriography followed by revascularization has not been establi...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1161/01.cir.89.4.1545

    authors:

    更新日期:1994-04-01 00:00:00

  • Impact of nonoperative therapy on the clinical management of peripheral arterial disease.

    abstract::Nonoperative therapy includes conservative noninterventional modalities and the endovascular interventional modalities of percutaneous transluminal angioplasty and a variety of laser systems and atherectomy devices. The role and impact of all nonoperative treatments are considered in the perspectives of the natural hi...

    journal_title:Circulation

    pub_type: 杂志文章,评审

    doi:

    authors: Veith FJ,Gupta SK,Wengerter KR,Rivers SP,Bakal CW

    更新日期:1991-02-01 00:00:00

  • Lack of association between the MEF2A gene and myocardial infarction.

    abstract:BACKGROUND:Coronary artery disease (CAD) and myocardial infarction (MI) are caused in part by genetic factors. Recently, the MEF2A gene was linked to MI/CAD in a single pedigree with autosomal-dominant pattern of inheritance. In addition, genetic variants within the gene have been associated with MI in case-control set...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.107.728485

    authors: Lieb W,Mayer B,König IR,Borwitzky I,Götz A,Kain S,Hengstenberg C,Linsel-Nitschke P,Fischer M,Döring A,Wichmann HE,Meitinger T,Kreutz R,Ziegler A,Schunkert H,Erdmann J

    更新日期:2008-01-15 00:00:00

  • Ninety-minute exclusion of acute myocardial infarction by use of quantitative point-of-care testing of myoglobin and troponin I.

    abstract:BACKGROUND:Diagnostic strategies with ECG and serum cardiac markers have been used to rule out acute myocardial infarction in 6 to 12 hours. The present study evaluated whether a multimarker strategy that used point-of-care measurement of myoglobin, creatine kinase (CK)-MB, and troponin I could exclude acute myocardial...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/hc3801.096336

    authors: McCord J,Nowak RM,McCullough PA,Foreback C,Borzak S,Tokarski G,Tomlanovich MC,Jacobsen G,Weaver WD

    更新日期:2001-09-25 00:00:00

  • Relation between left ventricular oxygen consumption and pressure-volume area in conscious dogs.

    abstract:BACKGROUND:The relation between left ventricular (LV) oxygen consumption (MVO2) and pressure-volume area (PVA) developed in isolated hearts provides a powerful method to understand cardiac energetics. We investigated application of this relation to the intact circulation, determining its response to steady-state and tr...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.89.2.810

    authors: Nozawa T,Cheng CP,Noda T,Little WC

    更新日期:1994-02-01 00:00:00