Multicenter, randomized, double-blind study comparing 20 and 40 mg of pantoprazole for symptom relief in adolescents (12 to 16 years of age) with gastroesophageal reflux disease (GERD).

Abstract:

:An age-appropriate questionnaire (GASP-Q) was used to assess the frequency and severity of the gastroesophageal reflux disease (GERD) symptoms: abdominal/belly pain, chest pain/heartburn, pain after eating, nausea, burping/belching, vomiting/regurgitation, choking when eating, and difficulty swallowing, in adolescents age 12 to 16 years. The primary objective was to compare the mean composite symptom score (CSS) at week 8 with baseline after treatment with 20 or 40 mg of pantoprazole. Statistically significant (p < 0.001) improvement in CSS occurred in both groups. Safety was comparable between the 2 groups. Pantoprazole was safe, well tolerated, and effective in reducing symptoms of GERD in adolescents.

journal_name

Clin Pediatr (Phila)

journal_title

Clinical pediatrics

authors

Tsou VM,Baker R,Book L,Hammo AH,Soffer EF,Wang W,Comer GM,326 Study Group.

doi

10.1177/0009922806292792

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

741-9

issue

8

eissn

0009-9228

issn

1938-2707

pii

45/8/741

journal_volume

45

pub_type

杂志文章,多中心研究,随机对照试验
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    pub_type: 杂志文章

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    更新日期:1998-11-01 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验

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    更新日期:1987-05-01 00:00:00

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    doi:10.1177/000992280003900806

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    更新日期:2000-08-01 00:00:00

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    更新日期:1994-02-01 00:00:00

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    pub_type: 杂志文章,随机对照试验

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    pub_type: 杂志文章,评审

    doi:10.1177/0009922893032001s02

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    更新日期:1993-07-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:1985-09-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1177/000992289002900105

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    更新日期:1990-01-01 00:00:00

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:10.1177/000992288502400305

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    更新日期:1985-03-01 00:00:00

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