Persistent hypertransaminasemia as the presenting finding of childhood muscle disease.

Abstract:

:Four children with isolated, persistent elevations of serum transaminases were investigated for hepatic disease and followed for 4 to 24 months before serum creatine kinase determinations were obtained and found to be markedly elevated. Evidence of muscle disease was obtained by close questioning, retrospectively, and mild abnormalities were found on physical examination. Review of laboratory tests in our center for 6 months revealed 30 additional cases of anicteric hypertransaminasemia (20% of those with elevated enzymes), only two of which were unexplained by the admitting diagnosis. Serum transaminase values are elevated in a variety of diseases of different organ systems. Creatine kinase determinations may provide the clue to the diagnosis of occult muscle disease in some children with unexplained anicteric hypertransaminasemia.

journal_name

Clin Pediatr (Phila)

journal_title

Clinical pediatrics

authors

Rutledge J,Andersen J,Fink CW,Cook J,Strickland A

doi

10.1177/000992288502400906

subject

Has Abstract

pub_date

1985-09-01 00:00:00

pages

500-3

issue

9

eissn

0009-9228

issn

1938-2707

journal_volume

24

pub_type

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