Time to stop blaming gastroesophageal reflux.

Abstract:

:OBJECTIVES. Cough, pain, and desaturation episodes in infants are often ascribed to gastroesophageal reflux, and many are empirically treated with acid suppression medications. The authors hypothesize that most of these symptoms are not related to gastroesophageal reflux. METHODS. Retrospective review of 186 combined pH-multichannel intraluminal impedance studies performed in infants at Cincinnati Children's Hospital. RESULTS. Of 4159 symptoms reported 1504 (36%) were associated with reflux events (27% nonacid and 9% acid). When total number of symptoms and reflux events were taken into consideration, nonacid reflux events were as likely to be associated with a symptom as acid reflux events (P = .66). CONCLUSION. The extra-esophageal symptoms commonly attributed to gastroesophageal reflux in infants are most often not associated with a reflux event. Even though causality cannot be definitively proven, in the minority in whom a symptom association is observed, nonacid events are as likely as acid events to cause symptoms.

journal_name

Clin Pediatr (Phila)

journal_title

Clinical pediatrics

authors

Garza JM,Nylund CM,Kaul A

doi

10.1177/0009922811412585

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

1110-5

issue

12

eissn

0009-9228

issn

1938-2707

pii

0009922811412585

journal_volume

50

pub_type

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