Abstract:
:The purpose of this study was to compare the bacteriologic and clinical efficacy of oral penicillin versus amoxicillin as first-line therapy for group A beta-hemolytic streptococcal (GABHS) tonsillopharyngitis. The prospective observational study was conducted over 18 months (January 2000-June 2001). Children enrolled had acute onset of symptoms and signs and a laboratory-documented GABHS tonsillopharyngitis illness. Follow-up examination and laboratory testing occurred 10 +/- 4 days following completion of treatment. In total, 389 patients were enrolled (intent-to-treat group): 195 received penicillin V and 194 received amoxicillin. Fifty-six of the penicillin-treated and 57 amoxicillin-treated patients refused to take the drug, or were noncompliant, or did not return for the follow-up visit, leaving 276 patients in the per-protocol group: 139 penicillin-treated and 137 amoxicillin-treated. Bacteriologic cure for amoxicillin-treated children occurred in 76% versus 64% in the penicillin-treated children (p = 0.04). The clinical cure rate for amoxicillin-treated children was 84% compared to 73% in the penicillin-treated children (p = 0.03). Since treatment allocation was not randomized, logistic regression analysis was used to adjust for treatment group differences. The odds ratio (OR) estimate for cure for patients in the amoxicillin versus penicillin V treatment group remained significant (OR = 1.84, 95% confidence interval 1.02-3.29); the same was true for dinical cure (OR = 1.99, 95% CI = 1.02-3.87). Amoxicillin may be superior to penicillin for bacteriologic and clinical cure of GABHS tonsillopharyngitis.
journal_name
Clin Pediatr (Phila)journal_title
Clinical pediatricsauthors
Curtin-Wirt C,Casey JR,Murray PC,Cleary CT,Hoeger WJ,Marsocci SM,Murphy ML,Francis AB,Pichichero MEdoi
10.1177/000992280304200305subject
Has Abstractpub_date
2003-04-01 00:00:00pages
219-25issue
3eissn
0009-9228issn
1938-2707journal_volume
42pub_type
临床试验,杂志文章,评审abstract::The utility of multicenter cognitive test methodology and resultant outcomes of supplementation with docosahexaenoic acid in healthy 4-year-old children was evaluated in a randomized, placebo-controlled, double-blind study. Subjects received 400-mg/d docosahexaenoic acid (n = 85) or matching placebo (n = 90) in capsul...
journal_title:Clinical pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/0009922807311730
更新日期:2008-05-01 00:00:00
abstract::An eight-year-old boy developed staphylococcal endocarditis. He was treated initially with nafcillin and gentamicin, but he remained febrile. The minimum bactericidal concentration (MBC) of nafcillin was 130 times the minimum inhibitory concentration (MIC). Following the addition of rifampin to the antibiotic regimen,...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288202100414
更新日期:1982-04-01 00:00:00
abstract:OBJECTIVE:To describe the incidence of bilious vomiting in infants with infantile hypertrophic pyloric stenosis that presented to a pediatric emergency department. METHODS:A retrospective medical record review included all infants who presented to our level 1 pediatric emergency department from January 1, 2005, throug...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922811431159
更新日期:2012-03-01 00:00:00
abstract::Although considerable attention has focused on the pathophysiology and external dermatologic consequences of epidermolysis bullosa (EB), head and neck mucosal manifestations pose specific management problems. The otolaryngologic aspects of EB, with emphasis on involvement and treatment of the ears, oral cavity and tee...
journal_title:Clinical pediatrics
pub_type: 杂志文章,评审
doi:10.1177/000992289203100204
更新日期:1992-02-01 00:00:00
abstract::Although copper deficiency is a rare occurrence in the developed world, attention should be given to the proper supplementation of minerals to at-risk pediatric patients. This study presents 3 distinct cases of copper deficiency in hospitalized patients aged 14 months, 6 years, and 12 years. Two patients had short bow...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922812446743
更新日期:2012-08-01 00:00:00
abstract::Central nervous system (CNS) complications of hemolytic-uremic syndrome (HUS) commonly consist of alterations in mental status, seizures, and rarely hemiparesis. The authors report the clinical evolution of left hemiparesis and later choreo-athetoid movements in a patient who sustained a right lacunar infarction as a ...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288702601106
更新日期:1987-11-01 00:00:00
abstract::Pediatrician reimbursement is shifting from fee-for-service to a fixed salary. In the Netherlands, as physicians working on a fee-for-service basis have a financial interest in talking less and in carrying out more diagnostic tests and investigations, it may be questioned whether this will influence the structure and ...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992280003901004
更新日期:2000-10-01 00:00:00
abstract::Osteoporosis causes significant morbidity for boys with Duchenne muscular dystrophy. Corticosteroid therapy given to prolong mobility may increase the rate of osteoporosis and risk of fracture. This study of 33 boys with Duchenne muscular dystrophy determined retrospectively the incidence of vertebral fractures partic...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992280304200408
更新日期:2003-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy and feasibility of a multifaceted, community-based weight intervention program for children using exergaming technology (activity-promoting video gaming). DESIGN AND METHODS:This is a prospective observational pilot study. Forty-eight children, between the ages of 8 and 16 years, who...
journal_title:Clinical pediatrics
pub_type: 临床试验,杂志文章
doi:10.1177/0009922811429480
更新日期:2012-04-01 00:00:00
abstract::We sought to determine if a simple educational intervention initiated at the first well-child care visit, with reinforcement at subsequent visits, can improve inner-city infant immunization rates. We conducted a controlled trial involving 315 newborn infants and their primary caregivers in 3 inner-city primary care ce...
journal_title:Clinical pediatrics
pub_type: 临床试验,杂志文章
doi:10.1177/000992280104000701
更新日期:2001-07-01 00:00:00
abstract::The goal of this study was to determine the value of a certified child life specialist (CCLS) on the patient and staff experiences in an epilepsy monitoring unit (EMU). We integrated a CCLS into the EMU for all children as well as adults with intellectual disability. We surveyed families to determine the impact of chi...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922818769469
更新日期:2018-10-01 00:00:00
abstract::Four neonates with adrenal hemorrhage are presented. The clinical manifestations included most often an abdominal mass but also anemia, jaundice, hypotension, bluish discoloration of the scrotum, and abdominal calcification. The diagnosis was established in each case upon abdominal sonographic findings. The review of ...
journal_title:Clinical pediatrics
pub_type: 杂志文章,评审
doi:10.1177/000992280104001002
更新日期:2001-10-01 00:00:00
abstract::The records of 20 children with imported malaria admitted to Kings County Hospital between October 1987 and May 1995 were reviewed. All had a history of recent travel or immigration from a malaria endemic area (West-Africa [16], Central-America [three], and the Caribbean [one]). None of the 10 children with a travel h...
journal_title:Clinical pediatrics
pub_type: 杂志文章,评审
doi:10.1177/000992289903800603
更新日期:1999-06-01 00:00:00
abstract::A common presenting problem of children in pediatric practice is the constellation of symptoms involving difficulty in completing assignments, trouble with written work, and organizational problems. Typically, these children do not have difficulty with reading but show problems with academic achievement. We have recen...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288302200401
更新日期:1983-04-01 00:00:00
abstract::We reviewed 74 outpatient febrile episodes in 22 pediatric heart transplant patients in order to determine etiologies, rates of serious and nonserious illness, and factors predictive of serious disease. Twenty-two febrile episodes (30%) resulted in hospital admission. Only three variables were predictive of serious il...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992289603500902
更新日期:1996-09-01 00:00:00
abstract::A considerable percentage of American children and adults fail to learn adequate literacy skills and read below a third grade level. Shared book reading is perhaps the single most important activity to prepare young children for success in reading. The primary objective of this manuscript was to critically review the ...
journal_title:Clinical pediatrics
pub_type: 杂志文章,评审
doi:10.1177/0009922813507995
更新日期:2014-04-01 00:00:00
abstract::To compare parental compliance with after-hours triage advice provided by telephone advice nurses and on-call pediatricians, a randomized controlled trial was undertaken at a university general pediatrics practice that enrolled parents or guardians calling for after-hours advice. Advice calls were randomized to a call...
journal_title:Clinical pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/000992280304200707
更新日期:2003-09-01 00:00:00
abstract::Tests with the Bayley Motor Scale were given to 288 infants, equally divided by sex, in Yucatan, Mexico. These were 2 to 54 weeks in age and came from three sociocultural levels. In comparison to USA infants, early acceleration of motor development was followed by a marked downward trend. This phenomenon, if observed ...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992287801701106
更新日期:1978-11-01 00:00:00
abstract::A case of an 11-year-old girl with autoimmune hypothyroidism and a positive sweat test is presented. When the hypothyroidism was corrected the sweat test reverted to normal. ...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288902801110
更新日期:1989-11-01 00:00:00
abstract::To describe pediatric clinicians' adherence to practice recommendations for obesity prevention and treatment, we conducted a cross-sectional analysis of 227 medical records of 3- to 18-year-old patients (seen from September 2003 to April 2004) and a longitudinal analysis of data from 632 overweight and obese patients ...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922809346567
更新日期:2010-02-01 00:00:00
abstract::Among 145 patients treated with recombinant human growth hormone (GH), four developed sleep apnea (two obstructive, two mixed) associated with tonsillar and adenoidal hypertrophy in three. These four patients had no local risk factors predisposing to upper airway obstruction (i.e., frequent pharyngitis or sinusitis). ...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992289703600602
更新日期:1997-06-01 00:00:00
abstract::This study was done to evaluate the spectrum of diagnoses and identify risk factors for significant kidney disease in asymptomatic children with proteinuria and/or microhematuria detected by routine urinalysis. Clinical and laboratory data were obtained by retrospective chart review of 239 patients referred to a terti...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992280504400105
更新日期:2005-01-01 00:00:00
abstract::For 'Factors Associated With Specific Language Impairment and Later Language Development During Early Life: A Literature Review' by Benjamas Prathanee, MA, Bandit Thinkhamrop, PhD, Sumalee Dechongkit, PhD; Clinical Pediatrics; Volume 46 Number 1, January 2007; 22-29; © 2007; SAGE Publications; 10.1177/0009922806297153...
journal_title:Clinical pediatrics
pub_type: 杂志文章,已发布勘误
doi:10.1177/0009922817720961
更新日期:2017-09-01 00:00:00
abstract::With many asthmatic children for whom emotional factors are significant, joint pediatric and psychiatric management is essential. A three-level model of collaboration is presented, including (1) pediatric care, (2) psychiatric consultation, and (3) inpatient psychosomatic treatment. The organization, professional role...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288102001203
更新日期:1981-12-01 00:00:00
abstract::The value of sonography in assessing chronic abdominal pain (CAP) in children, the characteristics of CAP, and the local pediatrician's practice in evaluating CAP are reported. Fifty-seven patients with CAP had abdominal and/or pelvic sonography; 56 were normal. One sonogram showed an ovarian cyst on the side opposite...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992289303200304
更新日期:1993-03-01 00:00:00
abstract::The authors administered an abbreviated revision of a previously field-tested, self-administered, brief screening test (the 30-item Drug and Alcohol Problem Quick Screen) to 355 consecutive middle-class adolescent patients seen at a five-pediatrician group practice setting. Ninety-six percent (341) of the subjects com...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992289002900106
更新日期:1990-01-01 00:00:00
abstract::In April of 1975, the United States government evacuated approximately 2,000 orphans from Vietnam and Cambodia. More than 1,500 orphans received initial medical evaluation and treatment at Clark Air Force Base, Republic of the Phillipines. The orphans underwent a minimum of 2 physician evaluations and were individuall...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992287701600310
更新日期:1977-03-01 00:00:00
abstract::A required PL-3 rotation in community pediatrics, including assignments to preschool and school settings, private pediatric offices, and in-hospital responsibilities, is described. A university-affiliated community hospital provides the organizational base for the program. After 14 PL-3 rotations, analysis of program ...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288102000403
更新日期:1981-04-01 00:00:00
abstract::A comprehensive program was founded in 1982 to provide adolescents with prenatal and family planning care. The program's impact through its first five years of operation on medical aspects of pregnancy course and fetal outcome will be the subject of a separate report. This study examines subsequent maternal and infant...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992289103000508
更新日期:1991-05-01 00:00:00
abstract::An infant exposed in utero to valproic acid was born with multiple congenital malformations, including duodenal atresia, lumbar vertebral fusion, thoracolumbar scoliosis, renal abnormalities, diastasis recti abdominis, depigmentation of the eyebrows, and a large hemangioma. The child had neonatal hyperbilirubinemia an...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288402300611
更新日期:1984-06-01 00:00:00