Assessing the effect of docosahexaenoic acid on cognitive functions in healthy, preschool children: a randomized, placebo-controlled, double-blind study.


:The utility of multicenter cognitive test methodology and resultant outcomes of supplementation with docosahexaenoic acid in healthy 4-year-old children was evaluated in a randomized, placebo-controlled, double-blind study. Subjects received 400-mg/d docosahexaenoic acid (n = 85) or matching placebo (n = 90) in capsules for 4 months. Cognitive tests included the Leiter-R Test of Sustained Attention, Peabody Picture Vocabulary Test, Day-Night Stroop Test, and Conners' Kiddie Continuous Performance Test. The relationship of docosahexaenoic acid levels in capillary whole blood from a subsample (n = 93) with scores on cognitive tests was evaluated. For each test, results indicated that changes from baseline to end of treatment were not statistically significantly different between the docosahexaenoic acid group and the placebo group. Regression analysis, however, yielded a statistically significant positive (P = .018) association between the blood level of docosahexaenoic acid and higher scores on the Peabody Picture Vocabulary Test, a test of listening comprehension and vocabulary acquisition.


Clin Pediatr (Phila)


Clinical pediatrics


Ryan AS,Nelson EB




Has Abstract


2008-05-01 00:00:00














  • Urban parents' perceptions of healthy infant growth.

    abstract::To examine how urban parents' perceptions of healthy infant size and growth relate to objective weight-for-length percentiles of their children, parents of 222 (69% minority) 6- to 27-month-old infants were surveyed. In all, 41% of parents said growth charts had never been explained to them, and 31% were not confident...

    journal_title:Clinical pediatrics

    pub_type: 杂志文章


    authors: Sullivan SA,Leite KR,Shaffer ML,Birch LL,Paul IM

    更新日期:2011-08-01 00:00:00

  • Health supervision visits of very young children: time addressing 3 key topics.

    abstract:OBJECTIVE:To describe the time and actions on 3 key health topics during health supervision (HS) visits of children aged 0 to 1 years. METHOD:HS visits were observed at 5 offices. Parents provided demographics and children's measurements were obtained. Using special computer software, visits were observed for frequenc...

    journal_title:Clinical pediatrics

    pub_type: 杂志文章


    authors: Manning KM,Ariza AJ,Massimino TK,Binns HJ,Pediatric Practice Research Group.

    更新日期:2009-11-01 00:00:00

  • Primary care physicians' knowledge of and confidence in their referrals for special education services in 3- to 5-year-old children.

    abstract:BACKGROUND:Children 3 to 5 years old with developmental delays are eligible for special education services. OBJECTIVE:To assess primary care physicians' (PCPs) knowledge, attitudes, and practices regarding their referrals to the special education system on behalf of children 3 to 5 years old. DESIGN/METHODS:Mail surv...

    journal_title:Clinical pediatrics

    pub_type: 杂志文章


    authors: Hastings EA,Lumeng JC,Clark SJ

    更新日期:2014-02-01 00:00:00

  • The magnesium load test: III. correlation of clinical and laboratory data in infants from one to six months of age.

    abstract::A study of 64 infants from one to six months of age was made using the 32-hour parenteral magnesium load test. Most of the infants were studied for neuromuscular hyperirritability or other signs compatible with magnesium deficiency; some with unrelated problems served as controls. Magnesium retention below 40 per cent...

    journal_title:Clinical pediatrics

    pub_type: 杂志文章


    authors: Caddell JL,Byrne PA,Triska RA,McElfresh AE

    更新日期:1975-05-01 00:00:00

  • Safety words inventory and literacy screener: standardization and validation.

    abstract::When evaluating a school-aged patient, particularly for such issues as attention deficit disorder, or learning disabilities, health-care providers are encouraged to appraise children's school performance. Although some clinicians seek teachers' comments, recent research suggests that teachers' appraisals have limited ...

    journal_title:Clinical pediatrics

    pub_type: 杂志文章


    authors: Glascoe FP

    更新日期:2002-11-01 00:00:00

  • Congenital dislocation of the hip--diagnostic screening and treatment. A comparative study of two populations of infants and children.

    abstract::To understand why congenital dislocated hip (CDH) was diagnosed late (mean age: nine months) in children admitted to the Children's Hospital of Philadelphia (CHOP), 714 consecutive CHOP admissions, aged zero to two years, and 947 consecutive newborns delivered at the Hospital, University of Pennsylvania (HUP) were exa...

    journal_title:Clinical pediatrics

    pub_type: 杂志文章


    authors: Kadkhoda M,Chung SM,Adebonojo FO

    更新日期:1976-03-01 00:00:00

  • Acute reversible pulmonary ischemia. A cause of the acute chest syndrome in sickle cell disease.

    abstract::A 6-year-old girl with sickle cell disease was admitted to the hospital with the diagnosis of the acute chest syndrome. The laboratory findings and the radionuclear lung scan supported a diagnosis of pulmonary infarction rather than pneumonia. She improved with intravenous fluids, oxygen, penicillin, and theophylline....

    journal_title:Clinical pediatrics

    pub_type: 杂志文章


    authors: Babiker MA,Obeid HA,Ashong EF

    更新日期:1985-12-01 00:00:00

  • Urban emergency department utilization by adolescents.

    abstract::This study describes urban emergency department (ED) utilization and follow-up referral patterns among adolescents. ED visits for 14-19-year-old patients at an urban university hospital with adjacent adult and pediatric emergency departments during specified months in 1993 were retrospectively reviewed. A subgroup (n=...

    journal_title:Clinical pediatrics

    pub_type: 杂志文章


    authors: Grove DD,Lazebnik R,Petrack EM

    更新日期:2000-08-01 00:00:00

  • Test of a Conceptual Model to Explain Television Exposure of Head Start Children.

    abstract::Excessive television (TV) viewing by children can lead to negative health and developmental outcomes. Using structural equation modeling, this study tests a conceptual model to understand social and familial factors associated with TV exposure among a sample of 767 Head Start families with children between the ages of...

    journal_title:Clinical pediatrics

    pub_type: 杂志文章


    authors: Swindle TM,Jarrett D,McKelvey LM,Whiteside-Mansell L,Conners Edge NA,Kraleti S

    更新日期:2018-07-01 00:00:00

  • The parental appraisal of the morbidity of diarrhea in infants and toddlers (PAMODI) survey.

    abstract::This study analyzed parental perception of the impact of diarrhea on quality of life of their children. A standardized questionnaire was completed by 2023 parents in Germany with children with diarrhea who were younger than 2 years old. Parents stated the most worrying aspects of diarrhea. A health score was measured ...

    journal_title:Clinical pediatrics

    pub_type: 杂志文章


    authors: Huppertz HI,Forster J,Heininger U,Roos R,Neumann HU,Hammerschmidt T

    更新日期:2008-05-01 00:00:00

  • Bacteremia in patients with cystic fibrosis.

    abstract::Bacteremia in patients with cystic fibrosis (CF) has not been previously reported, a fact probably attributable to activated systemic immunity in the presence of chronic bronchopulmonary infection. We have observed two CF patients under a year of age with documented bacteremia, and a teen-aged patient with autopsy evi...

    journal_title:Clinical pediatrics

    pub_type: 杂志文章


    authors: McCarthy MM,Rourk MH,Spock A

    更新日期:1980-11-01 00:00:00

  • Proposed guidelines for screening of metabolic and endocrine diseases of dependent neonates of the U.S. Armed Forces. Derived from a survey of state guidelines for neonatal screening of metabolic diseases.

    abstract::State regulations for neonatal screening for metabolic diseases do not optimally serve the needs of the dependents of the U.S. Armed Forces. Guidelines are therefore proposed for the neonatal screening for metabolic disease based both on responses received across the United States and on the unique needs of the U.S. A...

    journal_title:Clinical pediatrics

    pub_type: 杂志文章


    authors: Tiwary CM

    更新日期:1987-07-01 00:00:00

  • Does an Eczema Action Plan Improve Atopic Dermatitis? A Single-Site Randomized Controlled Trial.

    abstract::The multitude of treatment options for atopic dermatitis (AD) makes management frustrating for providers and patients. Eczema action plans (EAPs) have been proposed to improve parental and provider management. We developed a single-site randomized controlled trial to evaluate the impact of an EAP on quality of life (Q...

    journal_title:Clinical pediatrics

    pub_type: 杂志文章,随机对照试验


    authors: Brown J,Weitz NW,Liang A,Stockwell MS,Friedman S

    更新日期:2018-12-01 00:00:00

  • Lead intoxication from lead-contaminated water used to reconstitute infant formula.

    abstract::The lead found in drinking water can be a source of lead poisoning to young children, particularly those who consume large amounts of water. The authors describe a 13-month-old infant who was discovered to have plumbism during routine evaluation. The lead source was ultimately traced to the daily administration of pow...

    journal_title:Clinical pediatrics

    pub_type: 杂志文章


    authors: Shannon M,Graef JW

    更新日期:1989-08-01 00:00:00

  • Evaluating Partial Series Childhood Vaccination Services in a Mobile Clinic Setting.

    abstract::This study aims to evaluate the cost-benefit of vaccination services, mostly partial series administration, provided by a mobile clinic program (MCP) in Houston for children of transient and low-income families. The study included 469 patients who visited the mobile clinics on regular service days in 2 study periods i...

    journal_title:Clinical pediatrics

    pub_type: 杂志文章


    authors: Chen W,Misra SM,Zhou F,Sahni LC,Boom JA,Messonnier M

    更新日期:2020-06-01 00:00:00

  • Pitfalls on the diagnosis of acute osteomyelitis by bone scan.

    abstract::Two patients with acute osteomyelitis had technetium 99m methylene diphosphonate bone images that were misinterpreted. A review of six prospective evaluations of technetium scanning in the diagnosis of acute osteomyelitis shows that bone image interpretation may be misleading in five to seven per cent of pediatric pat...

    journal_title:Clinical pediatrics

    pub_type: 杂志文章


    authors: Wald ER,Mirro R,Gartner JC

    更新日期:1980-09-01 00:00:00

  • Evaluating oral health needs in preschool children.

    abstract::Pediatricians and family physicians can play a significant role in the initiation of dental care for preschool children because they are seen more often by a physician than a dentist. The Committee on Standards for Child Health Care of the American Academy of Pediatrics recommends inspection of the mouth, teeth, and g...

    journal_title:Clinical pediatrics

    pub_type: 杂志文章


    authors: Nirschl RF,Kronmiller JE

    更新日期:1986-07-01 00:00:00

  • Corrigendum.

    abstract::Falszewska A, Dziechciarz P, Szajewska H. The diagnostic accuracy of Clinical Dehydration Scale in identifying dehydration in children with acute gastroenteritis: a systematic review. Clin Pediatr (Phila). 2014;53:1181-8. (Original DOI: 10.1177/0009922814538493 ). ...

    journal_title:Clinical pediatrics

    pub_type: 杂志文章,已发布勘误



    更新日期:2018-01-01 00:00:00

  • Skull erosion and bony changes in a child with endocardial cushion defect.

    abstract::A 9-year-old boy with an endocardial cushion defect who had skull erosion as well as widening of the diploe is described. This was accompanied by thickening of the tables, "hair-on-end" striations in the skull, and cortical thinning and medullary cavity expansion in the femora. The skull erosion is attributed to venou...

    journal_title:Clinical pediatrics

    pub_type: 杂志文章


    authors: Hegde HR,Tyrrell MJ,Wilson DR,Leung AK

    更新日期:1988-01-01 00:00:00

  • Helicobacter pylori disease in childhood.

    abstract::Helicobacter pylori (H. pylori) is responsible for one of the most frequently encountered infectious diseases worldwide. H. pylori infection can lead to the development of gastritis and peptic ulcer disease. The presence of H. pylori in the human stomach also represents an increased risk for gastric cancer and gastric...

    journal_title:Clinical pediatrics

    pub_type: 杂志文章,评审


    authors: Blecker U

    更新日期:1996-04-01 00:00:00

  • Persistent hypertransaminasemia as the presenting finding of childhood muscle disease.

    abstract::Four children with isolated, persistent elevations of serum transaminases were investigated for hepatic disease and followed for 4 to 24 months before serum creatine kinase determinations were obtained and found to be markedly elevated. Evidence of muscle disease was obtained by close questioning, retrospectively, and...

    journal_title:Clinical pediatrics

    pub_type: 杂志文章


    authors: Rutledge J,Andersen J,Fink CW,Cook J,Strickland A

    更新日期:1985-09-01 00:00:00

  • Applying practice recommendations for the prevention and treatment of obesity in children and adolescents.

    abstract::To describe pediatric clinicians' adherence to practice recommendations for obesity prevention and treatment, we conducted a cross-sectional analysis of 227 medical records of 3- to 18-year-old patients (seen from September 2003 to April 2004) and a longitudinal analysis of data from 632 overweight and obese patients ...

    journal_title:Clinical pediatrics

    pub_type: 杂志文章


    authors: Dorsey KB,Mauldon M,Magraw R,Valka J,Yu S,Krumholz HM

    更新日期:2010-02-01 00:00:00

  • Vertebral fractures in boys with Duchenne muscular dystrophy.

    abstract::Osteoporosis causes significant morbidity for boys with Duchenne muscular dystrophy. Corticosteroid therapy given to prolong mobility may increase the rate of osteoporosis and risk of fracture. This study of 33 boys with Duchenne muscular dystrophy determined retrospectively the incidence of vertebral fractures partic...

    journal_title:Clinical pediatrics

    pub_type: 杂志文章


    authors: Bothwell JE,Gordon KE,Dooley JM,MacSween J,Cummings EA,Salisbury S

    更新日期:2003-05-01 00:00:00

  • Results from a clinical multidisciplinary weight management program.

    abstract:BACKGROUND/OBJECTIVE:Published data regarding outcomes of pediatric behavioral weight management are mainly from research interventions. The authors wished to explore outcomes from a clinical program. METHODS:A retrospective analysis of data from obese adolescents enrolled in the Michigan Pediatric Outpatient Weight E...

    journal_title:Clinical pediatrics

    pub_type: 杂志文章


    authors: Woolford SJ,Sallinen BJ,Clark SJ,Freed GL

    更新日期:2011-03-01 00:00:00

  • Infection caused by Propionibacterium in children.

    abstract::Three hundred eighty-six isolates of Propionibacterium sp. were recovered from 2,003 specimens studied for the identification of anaerobic bacteria in children during a 15-year period. Three hundred forty-three (89%) of these were Propionibacterium acnes. A total of 50 (13%) Propionibacterium isolates identified from ...

    journal_title:Clinical pediatrics

    pub_type: 杂志文章


    authors: Brook I

    更新日期:1994-08-01 00:00:00

  • Correlation of nasopharyngeal and conjunctival cultures with middle ear fluid cultures in otitis media. A prospective study.

    abstract::Eighty children with acute otitis media (AOM) were prospectively studied to determine the correlation and clinical usefulness of nasopharyngeal (NP), conjunctival (CONJ), and middle ear fluid (MEF) cultures. NP cultures correlated more accurately with MEF (p less than 0.01) than did CONJ cultures (p less than 0.05) fo...

    journal_title:Clinical pediatrics

    pub_type: 杂志文章


    authors: Groothuis JR,Thompson J,Wright PF

    更新日期:1986-02-01 00:00:00

  • Lead on painted handles of kitchen utensils.

    abstract::The lead content of paint on wooden handles of kitchen utensils ranged from 0 to 9.7 per cent (97,000 ppm). Yellow paint showed the highest concentration of lead followed by green and red colors. The values of lead often exceeded the legal limit on toys and paint for use indoors. ...

    journal_title:Clinical pediatrics

    pub_type: 杂志文章


    authors: Hankin L,Heichel GH,Botsford RA

    更新日期:1976-07-01 00:00:00

  • Mild splenic sequestration crises in sickle-hemoglobin C disease.

    abstract::Acute splenic sequestration crisis ( ASSC ), a common complication in homozygous sickle cell anemia, has been described infrequently in sickle-hemoglobin C (SC) disease in the absence of high altitude exposure. In this report, we describe three children with hemoglobin SC disease who developed episodes of ASSC that we...

    journal_title:Clinical pediatrics

    pub_type: 杂志文章


    authors: Andrews J,Buchanan GR

    更新日期:1984-06-01 00:00:00

  • Early identification of hearing loss: listen to parents.

    abstract::Families of 49 hearing-impaired children responded to a questionnaire requesting information about the identification of their child's hearing loss. Parents were the first to suspect the hearing loss in 48 cases but more often than not were told that the child would outgrow it or was too young to test. When profession...

    journal_title:Clinical pediatrics

    pub_type: 杂志文章


    authors: Thompson MD,Thompson G

    更新日期:1991-02-01 00:00:00

  • Pseudocyesis in an adolescent patient. Case report and radiologic analysis.

    abstract::The physical and psychological changes of pseudocyesis have bewildered physicians since the time of Hippocrates. We present the case of a 14-year-old girl as a reminder that pseudocyesis needs to be considered in adolescents and that the diagnosis may not be obvious, even with current technologies. We document that ga...

    journal_title:Clinical pediatrics

    pub_type: 杂志文章


    authors: Rosenberg HK,Coleman BG,Croop J,Granowetter L,Evans AE

    更新日期:1983-10-01 00:00:00