Bacterial endocarditis with a tolerant staphylococcal organism.

Abstract:

:An eight-year-old boy developed staphylococcal endocarditis. He was treated initially with nafcillin and gentamicin, but he remained febrile. The minimum bactericidal concentration (MBC) of nafcillin was 130 times the minimum inhibitory concentration (MIC). Following the addition of rifampin to the antibiotic regimen, the patient became afebrile and recovered. The discrepancy between the MBC and MIC indicated tolerance to nafcillin. Tolerance is a mode of antibiotic resistance that must be considered in treating life-threatening illness.

journal_name

Clin Pediatr (Phila)

journal_title

Clinical pediatrics

authors

McMillan JA,Weiner LB

doi

10.1177/000992288202100414

subject

Has Abstract

pub_date

1982-04-01 00:00:00

pages

252-4

issue

4

eissn

0009-9228

issn

1938-2707

journal_volume

21

pub_type

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