Abstract:
:Much attention has been focused on the natural history of gastroesophageal reflux (GER) in neurologically normal infants which generally resolves by two years of age. In contrast, little is known of the outcome of GER diagnosed in normal older children. The charts of 32 children (21 males) without neurologic or esophageal anatomic abnormalities, age 3.5 to 16 years (mean = 9.8) at the time of diagnosis, were reviewed. Diagnosis was based on suggestive presenting symptoms and evaluation of prolonged intraesophageal pH monitoring. Esophagitis was diagnosed by histologic criteria in 16 of the 32 patients. Medical treatment consisted of prokinetic agents (metoclopramide, bethanechol) and H2-receptor antagonists. After a one to eight year follow-up period (mean +/- SD - 3.4 +/- 2.1), the symptoms in 13 children had resolved or were sufficiently improved to discontinue medication. In 13 patients, symptoms were improved but medication was required for adequate control. Four children were symptomatic without improvement in spite of medical therapy and two others required fundoplication for continued severe symptoms and refractory esophagitis. In summary, less than 50% of otherwise normal older children with GER undergo spontaneous resolution of marked improvement in symptoms and the remainder require continued long-term medical and/or surgical management.
journal_name
Clin Pediatr (Phila)journal_title
Clinical pediatricsauthors
Treem WR,Davis PM,Hyams JSdoi
10.1177/000992289103000705subject
Has Abstractpub_date
1991-07-01 00:00:00pages
435-40issue
7eissn
0009-9228issn
1938-2707journal_volume
30pub_type
杂志文章abstract::Central nervous system (CNS) complications of hemolytic-uremic syndrome (HUS) commonly consist of alterations in mental status, seizures, and rarely hemiparesis. The authors report the clinical evolution of left hemiparesis and later choreo-athetoid movements in a patient who sustained a right lacunar infarction as a ...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288702601106
更新日期:1987-11-01 00:00:00
abstract::We prospectively evaluated the incidence of difficulty in defecation in infants with gastroesophageal reflux who were treated with smaller volume feeds thickened with rice cereal and also assessed the effect of changing the cereal to oatmeal. We evaluated 53 thriving infants with uncomplicated gastroesophageal reflux ...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992280504400804
更新日期:2005-10-01 00:00:00
abstract::This study evaluated the taste palatability of liquid clindamycin and acetaminophen products on the market. Subjects rated the palatability of 3 clindamycin suspensions, 1 amoxicillin suspension (tasted twice), an acetaminophen elixir, and an acetaminophen suspension in a randomized blinded fashion on a 0 to 5 scale. ...
journal_title:Clinical pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1177/0009922816657151
更新日期:2017-02-01 00:00:00
abstract::Forty-one children suspected of having tuberculosis were simultaneously given an intermediate strength Mantoux test, an old tuberculin tine test (OT), and a purified protein derivative (PPD) tine test. Each test was read at 48 hours, and the largest diameter of induration was recorded. Twenty-nine patients had a posit...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288001900602
更新日期:1980-06-01 00:00:00
abstract::Three children presented with acute onset of hemiplegia following an upper respiratory infection. Angiography revealed irregulaities, beading, and slow flow of a peripheral branch of a middle cerebral artery. In addition, one child had narrowing of the cervical segment of the internal carotid artery. An inflammatory a...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992287601501209
更新日期:1976-12-01 00:00:00
abstract::Neonatal intensive care unit (NICU) survivors demonstrate handicapping sensorineural hearing loss up to 50 times more frequently than normal newborns, yet little is known about the etiology of the hearing loss. Theoretically, accurate identification and triage of a particular infant based on a clinical profile would b...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992289503400304
更新日期:1995-03-01 00:00:00
abstract::This study analyzed parental perception of the impact of diarrhea on quality of life of their children. A standardized questionnaire was completed by 2023 parents in Germany with children with diarrhea who were younger than 2 years old. Parents stated the most worrying aspects of diarrhea. A health score was measured ...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922807310933
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:Often diapers are not changed after infants pass urine. AIM:To define the association between the frequency of changing diapers and urinary tract infection (UTI) in infants. METHODS:Urine samples were tested in 131 infants (aged from 2 months to 2.5 years) who had a temperature > or =38 degrees C. The auth...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922808320696
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Little is known about the magnitude of multiple chronic conditions (MCC) in children. This study describes the prevalence of and patterns of comorbidities in children receiving Medicaid assistance. METHODS:Diagnoses from 5 years of Medicaid claims data were reviewed and identified 128,044 chi...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922815574073
更新日期:2015-04-01 00:00:00
abstract::Outcomes of tonsillectomy (with or without adenoidectomy [w/woA]) in hospitalized children are unclear. We sought, to describe the characteristics of hospitalized children who underwent tonsillectomy (w/woA), to estimate the prevalence of complications and to evaluate the relative impact of different comorbid conditio...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922815616885
更新日期:2016-06-01 00:00:00
abstract::Of 1045 children admitted with gastroenteritis over a 12-month period and studied retrospectively, serum sodium level was tested in 802. Sixty patients (7.5%) had hypernatremic dehydration (HD). The peak incidence of HD, the highest serum sodium levels, and the worst outcome were all encountered in infants under the a...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288402300501
更新日期:1984-05-01 00:00:00
abstract::Among 145 patients treated with recombinant human growth hormone (GH), four developed sleep apnea (two obstructive, two mixed) associated with tonsillar and adenoidal hypertrophy in three. These four patients had no local risk factors predisposing to upper airway obstruction (i.e., frequent pharyngitis or sinusitis). ...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992289703600602
更新日期:1997-06-01 00:00:00
abstract::This study examines primary care provider (PCP) experiences with the initial parental disclosure of cystic fibrosis (CF) newborn screening (NBS) results in order to identify methods to improve parent-provider communication during the CF NBS process. PCPs of infants who received positive CF NBS results participated in ...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922814545619
更新日期:2015-01-01 00:00:00
abstract::This study was undertaken to evaluate trends and toxicity of pediatric methylphenidate exposures; 1993 to 1999 national poison center data were analyzed. There were 12,917 exposures, increasing from 927 in 1993 to 2,445 in 1999. The majority of children during the entire study period experienced no effect (60.3%) or m...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992280304200210
更新日期:2003-03-01 00:00:00
abstract::We sought to determine if a simple educational intervention initiated at the first well-child care visit, with reinforcement at subsequent visits, can improve inner-city infant immunization rates. We conducted a controlled trial involving 315 newborn infants and their primary caregivers in 3 inner-city primary care ce...
journal_title:Clinical pediatrics
pub_type: 临床试验,杂志文章
doi:10.1177/000992280104000701
更新日期:2001-07-01 00:00:00
abstract::Objective To identify any socioeconomic, demographic, neonatal, and perinatal factors that may be associated with failing the otoacoustic emissions (OAE) newborn hearing screen. Study Design A retrospective chart review was performed looking at hearing screens performed on 1272 newborn infants by OAE testing. Socioeco...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922815615826
更新日期:2016-10-01 00:00:00
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journal_title:Clinical pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1177/0009922814540987
更新日期:2014-09-01 00:00:00
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journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922819845897
更新日期:2019-08-01 00:00:00
abstract::Two children presented with autoimmune alternating hypo- and hyperthyroidism related to the presence of blocking and stimulating thyroid antibodies. It was difficult to control their thyroid function adequately with an appropriate single drug regimen, and both children underwent total thyroidectomy with subsequent sta...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922811412583
更新日期:2011-11-01 00:00:00
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journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288402301210
更新日期:1984-12-01 00:00:00
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journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288001900904
更新日期:1980-09-01 00:00:00
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journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922820948261
更新日期:2021-01-01 00:00:00
abstract::IgG subclasses were measured in sera of 47 patients with acute hepatitis A during the course of the disease. IgG1 and IgG3 serum levels were found to be elevated, whereas IgG2 and IgG4 subclass concentrations did not differ from that found in healthy control individuals. These findings indicate that, similar to the sp...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992289002900811
更新日期:1990-08-01 00:00:00
abstract::The purpose of the Pediatric Overweight Quality Improvement Initiative (POWQII) was to demonstrate the feasibility and value of simple interventions for improving pediatric care and to address the additional needs of overweight and obese children. Practices were recruited from around New Mexico, with 16 pediatricians ...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922813480844
更新日期:2013-07-01 00:00:00
abstract::Our primary objective was to compare parents of infants cared for in newborn intensive care units (NICUs) and infants cared for in well-baby ("general") nurseries with regard to knowledge and practice of safe sleep practices/sudden infant death syndrome risk reduction measures and guidelines. Our secondary objective w...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922813506038
更新日期:2013-11-01 00:00:00
abstract::An eight-year-old boy developed staphylococcal endocarditis. He was treated initially with nafcillin and gentamicin, but he remained febrile. The minimum bactericidal concentration (MBC) of nafcillin was 130 times the minimum inhibitory concentration (MIC). Following the addition of rifampin to the antibiotic regimen,...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288202100414
更新日期:1982-04-01 00:00:00
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journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922806295281
更新日期:2006-11-01 00:00:00
abstract::Childhood thyrotoxicosis is not an uncommon illness, but there is a considerable relapse rate in these patients on medical treatment. An attempt is made in this study to identify those markers that are predictive of a tendency to relapse in childhood thyrotoxicosis. A total of 32 patients with Graves disease were incl...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288702600306
更新日期:1987-03-01 00:00:00
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journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922806290609
更新日期:2006-07-01 00:00:00
abstract::Between December 1980 and November 1984, the acute episode was studied prospectively in 187 children under 14 years presenting with acute poststreptococcal glomerulonephritis. The mean annual incidence was 19.5/10(5) children. The disease was mainly pharyngitis-associated and occurred throughout the year but peaked in...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288602500402
更新日期:1986-04-01 00:00:00