Sleep apnea in patients receiving growth hormone.

Abstract:

:Among 145 patients treated with recombinant human growth hormone (GH), four developed sleep apnea (two obstructive, two mixed) associated with tonsillar and adenoidal hypertrophy in three. These four patients had no local risk factors predisposing to upper airway obstruction (i.e., frequent pharyngitis or sinusitis). Clinical and/or polysomnographic features of sleep apnea improved following cessation of GH therapy in one patient, and following tonsillectomy and adenoidectomy in all patients. The present observations indicate that, albeit rarely, obstructive and/or central sleep apnea may occur in children treated with GH. Polysomnography should be considered if symptoms of snoring, interrupted sleep, daytime somnolence-particularly if associated with tonsillar hypertrophy-appear in children during GH therapy.

journal_name

Clin Pediatr (Phila)

journal_title

Clinical pediatrics

authors

Gerard JM,Garibaldi L,Myers SE,Aceto T Jr,Kotagal S,Gibbons VP,Stith J,Weber C

doi

10.1177/000992289703600602

subject

Has Abstract

pub_date

1997-06-01 00:00:00

pages

321-6

issue

6

eissn

0009-9228

issn

1938-2707

journal_volume

36

pub_type

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