Differential response profiles in children and adolescents with attention-deficit/hyperactivity disorder: treatment with atomoxetine.

Abstract:

:Atomoxetine has been shown to be safe and effective in the treatment of attention-deficit/hyperactivity disorder (ADHD). The purpose of this post hoc analysis was to examine response trajectories of pediatric patients treated with atomoxetine. Data were pooled from 7 atomoxetine double-blind, placebo-controlled clinical trials conducted in pediatric patients between November 1998 and June 2004. Growth mixture modeling was applied to the investigator-rated ADHD rating scale (ADHDRS-Inv) and Clinical Global Impressions-ADHD-Severity (CGI-ADHD-S) scores in the randomized acute phase (6-9 weeks) to explore whether there were groups of patients who differed in their response to atomoxetine. Classification and regression tree analyses were performed to identify predictors that can help categorize subjects to different response profiles. Patients (N = 925) were mostly male (73%) and of the combined subtype (74%). Most patients had a response pattern characterized by gradual, modest improvement, while a smaller group experienced early, robust improvement.

journal_name

Clin Pediatr (Phila)

journal_title

Clinical pediatrics

authors

Wietecha LA,Wang S,Saylor KE,Day KA,Wu SH,Kelsey D

doi

10.1177/0009922814555973

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

164-73

issue

2

eissn

0009-9228

issn

1938-2707

pii

0009922814555973

journal_volume

54

pub_type

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