Abstract:
:Atomoxetine has been shown to be safe and effective in the treatment of attention-deficit/hyperactivity disorder (ADHD). The purpose of this post hoc analysis was to examine response trajectories of pediatric patients treated with atomoxetine. Data were pooled from 7 atomoxetine double-blind, placebo-controlled clinical trials conducted in pediatric patients between November 1998 and June 2004. Growth mixture modeling was applied to the investigator-rated ADHD rating scale (ADHDRS-Inv) and Clinical Global Impressions-ADHD-Severity (CGI-ADHD-S) scores in the randomized acute phase (6-9 weeks) to explore whether there were groups of patients who differed in their response to atomoxetine. Classification and regression tree analyses were performed to identify predictors that can help categorize subjects to different response profiles. Patients (N = 925) were mostly male (73%) and of the combined subtype (74%). Most patients had a response pattern characterized by gradual, modest improvement, while a smaller group experienced early, robust improvement.
journal_name
Clin Pediatr (Phila)journal_title
Clinical pediatricsauthors
Wietecha LA,Wang S,Saylor KE,Day KA,Wu SH,Kelsey Ddoi
10.1177/0009922814555973subject
Has Abstractpub_date
2015-02-01 00:00:00pages
164-73issue
2eissn
0009-9228issn
1938-2707pii
0009922814555973journal_volume
54pub_type
杂志文章,随机对照试验abstract::This study was designed to objectively examine depression and distress levels in parents of ill versus parents of healthy neonates by utilizing two well-validated questionnaires, the Beck Depression Inventory (BDI) and Kellner Symptom Questionnaire (KSQ). In addition, morbidity of infants was assessed by the Minde-Whi...
journal_title:Clinical pediatrics
pub_type: 临床试验,杂志文章
doi:10.1177/000992289403300203
更新日期:1994-02-01 00:00:00
abstract::The Danish social system provides competent, accessible, continuous, and coordinated medical care to the pediatric population. The pediatrician does not deal with the routine aspects of well-infant and child care but is rather hospital based and acts on consultant to the generalists in his district. The generalist has...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992287501400409
更新日期:1975-04-01 00:00:00
abstract:BACKGROUND:This is a retrospective chart review of autistic patients presenting to the emergency department (ED) in a tertiary care pediatric center during the year 2011. RESULTS:There were 160 ED visits by 130 patients, 25% of visits were repeated, and 20% were admitted to the hospital. There were 126 (79%) male and ...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922814540983
更新日期:2014-10-01 00:00:00
abstract::There is a concern that lactation failure and neonatal morbidity might be more common than previously thought. Maybe the early discharge, the lack of timely follow-up, or poor information during pregnancy or after delivery play important roles. A case of severe hypernatremic dehydration secondary to lactation failure ...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992280604500211
更新日期:2006-03-01 00:00:00
abstract::Three cases are presented which illustrate the possible difficulties in differentiating between the diagnoses of Guillain-Barre Syndrome and conversion disorder. Accepted criteria are specified for each condition, as well as some associated features often characteristic of similar cases. Supportive interdisciplinary t...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992289103001002
更新日期:1991-10-01 00:00:00
abstract:BACKGROUND:Seven pediatric primary care practices participated in New Mexico's Developmental Screening Initiative in a year-long quality improvement project with the goal of implementing standardized developmental screening tools. METHODS:The initiative utilized a learning collaborative approach and the Model for Impr...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922814527499
更新日期:2014-06-01 00:00:00
abstract::This study was undertaken to evaluate trends and toxicity of pediatric methylphenidate exposures; 1993 to 1999 national poison center data were analyzed. There were 12,917 exposures, increasing from 927 in 1993 to 2,445 in 1999. The majority of children during the entire study period experienced no effect (60.3%) or m...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992280304200210
更新日期:2003-03-01 00:00:00
abstract::Helicobacter pylori (H. pylori) is responsible for one of the most frequently encountered infectious diseases worldwide. H. pylori infection can lead to the development of gastritis and peptic ulcer disease. The presence of H. pylori in the human stomach also represents an increased risk for gastric cancer and gastric...
journal_title:Clinical pediatrics
pub_type: 杂志文章,评审
doi:10.1177/000992289603500401
更新日期:1996-04-01 00:00:00
abstract::An association between the frequency of otitis media in early childhood and later hyperactivity is reported in this study. The subjects were 67 children referred to a child development clinic for evaluation of school failure. Ranging from 6 to 13 years old, all the children demonstrated specific school learning proble...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288702600508
更新日期:1987-05-01 00:00:00
abstract::Prior to the 1990s, most 46,XX infants with clitoromegaly secondary to congenital adrenal hyperplasia were treated with feminizing genitoplasty to make their cosmetic appearance congruent with their genotypic sex. A 2006 consensus statement for the management of intersex disorders accepted input from patient advocates...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922818803407
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVE:The qualitative research presented here is part of a larger project on the significance of medical clowning during invasive examinations in children in the Department of Gastroenterology and the Center for the Sexually Abused in a hospital in Israel. It investigated what makes up the essence of medical clowni...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922815598143
更新日期:2016-01-01 00:00:00
abstract::Eighty children with acute otitis media (AOM) were prospectively studied to determine the correlation and clinical usefulness of nasopharyngeal (NP), conjunctival (CONJ), and middle ear fluid (MEF) cultures. NP cultures correlated more accurately with MEF (p less than 0.01) than did CONJ cultures (p less than 0.05) fo...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288602500205
更新日期:1986-02-01 00:00:00
abstract:BACKGROUND:The purpose of our study was to compare caregiver perceptions of fever between ethnicities in a population with a large percentage of Hispanics. METHODS:A 20-item, cross-sectional survey was collected from English- and Spanish-speaking parents of children. Questions addressed level of parental worry, parent...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922809336208
更新日期:2010-02-01 00:00:00
abstract::Four neonates with adrenal hemorrhage are presented. The clinical manifestations included most often an abdominal mass but also anemia, jaundice, hypotension, bluish discoloration of the scrotum, and abdominal calcification. The diagnosis was established in each case upon abdominal sonographic findings. The review of ...
journal_title:Clinical pediatrics
pub_type: 杂志文章,评审
doi:10.1177/000992280104001002
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND:Control of environmental triggers (ETs) greatly improves asthma outcomes in children. Disseminating these findings to general pediatricians has not been well established. METHODS:After delivering a structured and standardized presentation on ET identification and control to pediatricians, we surveyed them a...
journal_title:Clinical pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1177/0009922813482752
更新日期:2013-06-01 00:00:00
abstract::Patients with cyclic vomiting syndrome suffer from recurring episodes of severe nausea and vomiting. This paper presents 6 patients who responded to 1-carnitine administration. Average time between episodes was 1.7 months before carnitine administration and increased to 1.1 years after carnitine administration. Averag...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992280204100307
更新日期:2002-04-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:Published data regarding outcomes of pediatric behavioral weight management are mainly from research interventions. The authors wished to explore outcomes from a clinical program. METHODS:A retrospective analysis of data from obese adolescents enrolled in the Michigan Pediatric Outpatient Weight E...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922810384845
更新日期:2011-03-01 00:00:00
abstract::Essential to the management of the sick, low birth weight infant is maintenance of a neutral thermal environment by use of convection incubators and radiant warmers. Manipulation of the infant in preparation for transfusion and the transfusion of cold blood could theoretically lower the infant's body temperature, subs...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288502401110
更新日期:1985-11-01 00:00:00
abstract::We reviewed 74 outpatient febrile episodes in 22 pediatric heart transplant patients in order to determine etiologies, rates of serious and nonserious illness, and factors predictive of serious disease. Twenty-two febrile episodes (30%) resulted in hospital admission. Only three variables were predictive of serious il...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992289603500902
更新日期:1996-09-01 00:00:00
abstract::The aim of this study was to evaluate the safety and efficacy of nonoperative treatment of esophageal perforation (EP) in children. Between 1999 and 2004, 13 episodes in 12 patients were evaluated. The treatment program consisted of broad-spectrum antibiotics, nasopharyngeal aspiration, parenteral and/or enteral nutri...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992280504400204
更新日期:2005-03-01 00:00:00
abstract::Our primary objective was to compare parents of infants cared for in newborn intensive care units (NICUs) and infants cared for in well-baby ("general") nurseries with regard to knowledge and practice of safe sleep practices/sudden infant death syndrome risk reduction measures and guidelines. Our secondary objective w...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922813506038
更新日期:2013-11-01 00:00:00
abstract::Follow-up survival and health information were obtained, after a median of 27.5 years, from 132 patients who had been seen originally as children with nephrotic syndrome between 1951 and 1967. Ninety seven patients were alive. Recurring edema or proteinuria, or both, persisted in 15 percent of those still alive. Eight...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288802700201
更新日期:1988-02-01 00:00:00
abstract:OBJECTIVES:Obstructive sleep apnea (OSA) and habitual snoring are highly prevalent childhood conditions and have been associated with a large array of negative health outcomes. Although guidelines were published by the American Academy of Pediatrics (AAP) a decade ago recommending routine screening of sleep-disordered ...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922812464548
更新日期:2012-12-01 00:00:00
abstract::Despite recommendations against routine imaging, chest radiography (CXR) is frequently performed on infants hospitalized for bronchiolitis. We conducted a review of 811 infants hospitalized for bronchiolitis to identify clinical factors associated with imaging findings. CXR was performed on 553 (68%) infants either on...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922817698802
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a major contributor to neonatal hyperbilirubinemia, yet newborn screening for this disorder in the United States is not standard practice. We surveyed pediatric providers regarding a novel newborn G6PD screening program successfully implemented in 2007 at...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922814557786
更新日期:2015-06-01 00:00:00
abstract::Clinical and laboratory findings of Zellweger syndrome (ZS) patients diagnosed at King Faisal Specialist Hospital and Research Center (KFSH & RC), Riyadh, Saudi Arabia over a period of 10 years are presented in this report. Eleven patients (nine females and two males) from 2 to 4 months old were referred to KFSH & RC ...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992289903800203
更新日期:1999-02-01 00:00:00
abstract::The purpose of this study was to assess the relationship between the clinical findings before starting treatment and the development quotient in children treated for congenital hypothyroidism. Patients with congenital hypothyroidism (n = 129) were divided into favorable and unfavorable groups according to intellectual...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922806289326
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:The American Academy of Pediatrics recommends that pediatricians promote smoking cessation among caregivers at every visit. Currently, there are inconsistencies between recommendations and clinical practice. This study aims to compare results generated from 3 intervention methods on the rate at which pedia...
journal_title:Clinical pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/0009922816688261
更新日期:2018-01-01 00:00:00
abstract::The purpose of this study was to determine the efficacy and safety of propofol sedation for pediatric procedures in the emergency department. For patients needing painful procedures, propofol was administered intravenously. Vital signs, complications, and time to recovery were recorded. Patient amnesia and parent, pat...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992280104001204
更新日期:2001-12-01 00:00:00
abstract::Eighty two infants, aged 2-12 months, were prospectively studied for infectious episodes following diphtheria-pertussis-tetanus (DPT) immunization. The occurrence of infectious episodes during the month following vaccination was compared to that during the month prior to its administration. The 3 days following vaccin...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288802701005
更新日期:1988-10-01 00:00:00