Abstract:
:The effect of magnetized physiological solution (MPS) on isolated, perfused snail heart muscle contractility, (45)Ca uptake and intracellular level of cAMP, and cGMP was studied. The existence of the relaxing effect of MPS on heart muscle at room temperature (22 degrees C) and its absence in cold medium (4 degrees C) was shown. The MPS had a depressing effect on (45)Ca uptake by muscles and intracellular cAMP content and an elevating effect on intracellular cGMP level. It is suggested that the relaxing effect of MPS on heart muscle is due to the decrease of intracellular Ca ions as the result of activation of cGMP-dependent Ca efflux. The MPS induced decrease of intracellular cAMP content can be considered as a consequence of intracellular Ca loss, leading to the Na + K-ATPase reactivation, and causing the decrease of the intracellular level of ATP, serving as a substrate and positive modulator of cyclase activity.
journal_name
Bioelectromagneticsjournal_title
Bioelectromagneticsauthors
Ayrapetyan G,Papanyan A,Hayrapetyan H,Ayrapetyan Sdoi
10.1002/bem.20145subject
Has Abstractpub_date
2005-12-01 00:00:00pages
624-30issue
8eissn
0197-8462issn
1521-186Xjournal_volume
26pub_type
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