Millimeter microwave effect on ion transport across lipid bilayer membranes.

Abstract:

:The effects of millimeter microwaves in the frequency range of 54-76 GHz on capacitance and conductance of lipid bilayer membranes (BLM) were studied. Some of the membranes were modified by gramicidin A and amphotericin B or by tetraphenylboron anions (TPhB-). The millimeter microwaves were pulse-modulated (PW) at repetition rates ranging from 1 to 100 pps, PW at 1000 pps, or unmodulated continuous waves (CW). The maximum output power at the waveguide outlet was 20 mW. It was found that CW irradiation decreased the unmodified BLM capacitance by 1.2% +/- 0.5%. At the same time, membrane current induced by TPhB- transport increased by 5% +/- 1%. The changes in conductance of ionic channels formed by gramicidin A and amphotericin B were small (0.6% +/- 0.4%). No "resonance-like" effects of mm-wave irradiation on membrane capacitance, ionic channel currents, or TPhB- transport were detected. All changes in membrane capacitance and currents were independent of the modulation employed and were equivalent to heating by approximately 1.1 degrees C.

journal_name

Bioelectromagnetics

journal_title

Bioelectromagnetics

authors

Alekseev SI,Ziskin MC

doi

10.1002/bem.2250160209

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

124-31

issue

2

eissn

0197-8462

issn

1521-186X

journal_volume

16

pub_type

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