Pulsed electromagnetic field therapy in the treatment of pain and other symptoms in fibromyalgia: A randomized controlled study.

Abstract:

:Low-energy pulsed electromagnetic field (PEMF) therapy has been suggested as a promising therapy to increase microcirculation, which is of great concern in patients with fibromyalgia. This study evaluated the effectiveness of PEMF therapy on the treatment of fibromyalgia. A group of 108 women with fibromyalgia were allocated to a 12-week treatment period with an active Bio-Electro-Magnetic-Energy-Regulation (BEMER) device and a similar treatment period with an inactive device. Each patient received active and sham treatments in a random order. Pain and stiffness were assessed on a visual analog scale (VAS, scale 0-100 mm), and functional status was assessed by the Fibromyalgia Impact Questionnaire (FIQ). Mean VAS pain scores before the active and sham treatment periods were 66 (SD 22) and 63 (SD 22), respectively. After treatment periods, mean VAS pain scores had decreased significantly in active treatment, -12, 95% CI [-18, -6], and in sham treatment, -11, 95% CI [-17, -5]. Similarly, the decrease in stiffness and FIQ index after both treatments was statistically significant. However, per-protocol analysis showed no differences between active and sham treatments at any of the outcomes. This study demonstrated that low-energy PEMF therapy was not efficient in reducing pain and stiffness or in improving functioning in women with fibromyalgia. Bioelectromagnetics. 39:405-413, 2018. © 2018 Wiley Periodicals, Inc.

journal_name

Bioelectromagnetics

journal_title

Bioelectromagnetics

authors

Multanen J,Häkkinen A,Heikkinen P,Kautiainen H,Mustalampi S,Ylinen J

doi

10.1002/bem.22127

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

405-413

issue

5

eissn

0197-8462

issn

1521-186X

journal_volume

39

pub_type

杂志文章,随机对照试验
  • Low-intensity microwave irradiation does not substantially alter gene expression in late larval and adult Caenorhabditis elegans.

    abstract::Reports that low-intensity microwave radiation induces heat-shock reporter gene expression in the nematode, Caenorhabditis elegans, have recently been reinterpreted as a subtle thermal effect caused by slight heating. This study used a microwave exposure system (1.0 GHz, 0.5 W power input; SAR 0.9-3 mW kg(-1) for 6-we...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.20515

    authors: Dawe AS,Bodhicharla RK,Graham NS,May ST,Reader T,Loader B,Gregory A,Swicord M,Bit-Babik G,de Pomerai DI

    更新日期:2009-12-01 00:00:00

  • Magnetic field therapy in patients with cytostatics-induced polyneuropathy: A prospective randomized placebo-controlled phase-III study.

    abstract::No causal treatment for chemotherapy-induced peripheral neuropathy (CIPN) is known. Therefore, there is an urgent need to develop a therapy for CIPN. Only scarce clinical data are available concerning magnetic field therapy (MFT) in this context. We conducted a unicentric, randomized, double-blind, placebo-controlled ...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/bem.22005

    authors: Rick O,von Hehn U,Mikus E,Dertinger H,Geiger G

    更新日期:2017-02-01 00:00:00

  • Acute effects of 50 Hz magnetic field exposure on human visual task and cardiovascular performance.

    abstract::One hundred subjects, males and females with ages ranging between 18 and 48 years, were studied under both field-exposed and sham-exposed conditions. A 50 Hz, 100 mu T magnetic field (MF) was used. To examine the effect of field exposure on performance, a two-alternative, forced-choice, duration-discrimination task wi...

    journal_title:Bioelectromagnetics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/(SICI)1521-186X(1996)17:2<131::AID-BEM7>3.

    authors: Whittington CJ,Podd JV,Rapley BR

    更新日期:1996-01-01 00:00:00

  • Simple nonperturbing temperature probe for microwave/radio frequency dosimetry.

    abstract::We present a simple readout device that fills the void produced by the gradual disappearance of the Vitck model 101 Electrothermia Monitor. The new device uses commercially available probes that are similar to Bowman's (IEEE Trans Microwave Theory Tech MTT-24:43-45, 1976) original design. As described, the device cove...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.2250100210

    authors: Olsen RG,Bowman RR

    更新日期:1989-01-01 00:00:00

  • Effects of ELF magnetic field on membrane protein structure of living HeLa cells studied by Fourier transform infrared spectroscopy.

    abstract::The effects of exposure to a 50 Hz magnetic field (maximum of 41.7 to 43.6 mT) on the membrane protein structures of living HeLa cells were studied using attenuated total reflection infrared spectroscopy. One min of such exposure shifted peak absorbance of the amide I band to a smaller wave number, reduced peak absorb...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.10120

    authors: Ikehara T,Yamaguchi H,Hosokawa K,Miyamoto H,Aizawa K

    更新日期:2003-10-01 00:00:00

  • Exposure system to study hypotheses of ELF and RF electromagnetic field interactions of mobile phones with the central nervous system.

    abstract::A novel exposure system for double-blind human electromagnetic provocation studies has been developed that satisfies the precision, control of fields and potential artifacts, and provides the flexibility to investigate the response of hypotheses-driven electromagnetic field exposure schemes on brain function, ranging ...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.21710

    authors: Murbach M,Christopoulou M,Crespo-Valero P,Achermann P,Kuster N

    更新日期:2012-09-01 00:00:00

  • Effects of a 30 kV/m, 60 Hz electric field on the social behavior of baboons: a crossover experiment.

    abstract::Using a crossover experimental design, we evaluated our earlier findings that exposure to a 30 kV/m, 60 Hz electric field for 12 hours per day, 7 days per week for 6 weeks produced significant changes in the performance rates of social behaviors among young adult male baboons. In the crossover experiment, the former c...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.2250130506

    authors: Easley SP,Coelho AM Jr,Rogers WR

    更新日期:1992-01-01 00:00:00

  • Dielectric properties of porcine brain tissue in the transition from life to death at frequencies from 800 to 1900 MHz.

    abstract::Ten experiments on pigs were performed to investigate possible postmortem changes of the dielectric properties of brain gray matter in the frequency range of 800-1900 MHz. After keeping the animals in stable anaesthesia for at least 45 min, they were euthanatised by an intravenous injection of hypertonic potassium chl...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.10122

    authors: Schmid G,Neubauer G,Illievich UM,Alesch F

    更新日期:2003-09-01 00:00:00

  • Neurobiological effects of pulsed magnetic field on diabetes-induced neuropathy.

    abstract::In the clinic, although several pharmacological agents or surgical procedures are used to treat diabetes and diabetes-induced neuropathic pain, their success has been limited. Therefore, development of different alternatives in treatments is very important. The purpose of this study was to determine the efficacy of pu...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.20524

    authors: Mert T,Gunay I,Ocal I

    更新日期:2010-01-01 00:00:00

  • Numerical and analytical methods to determine the current density distributions produced in human and rat models by electric and magnetic fields.

    abstract::Some numerical and analytical methods used to estimate the internal electric fields and current densities produced within human and animal models by low-frequency electric and magnetic fields are surveyed. A major goal of such modeling is the design of laboratory experiments on cellular systems or animal models to pro...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章,评审

    doi:10.1002/bem.2250130705

    authors: Hart FX

    更新日期:1992-01-01 00:00:00

  • Proflavin and microwave radiation: absence of a mutagenic interaction.

    abstract::The potential ability of radiofrequency electromagnetic radiation (RFR) in the microwave range to induce mutagenesis, chromosomal aberrations, and sister chromatid exchanges in mammalian cells is being explored in our laboratories. In addition, we have also been examining the ability of simultaneous exposure to RFR an...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.2250110206

    authors: Meltz ML,Eagan P,Erwin DN

    更新日期:1990-01-01 00:00:00

  • Resonance effect of millimeter waves in the power range from 10(-19) to 3 x 10(-3) W/cm2 on Escherichia coli cells at different concentrations.

    abstract::The effect of millimeter waves (MMWs) on the genome conformational state (GCS) of E. coli AB1157 cells was studied by the method of anomalous viscosity time dependencies (AVTD) in the frequency range of 51.64-51.85 GHz. The 51.755 GHz resonance frequency of the cell reaction to MMWs did not depend on power density (PD...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/(SICI)1521-186X(1996)17:4<312::AID-BEM7>3.

    authors: Belyaev IY,Shcheglov VS,Alipov YD,Polunin VA

    更新日期:1996-01-01 00:00:00

  • Effects of extremely-low-frequency magnetic fields on biological magnetite.

    abstract::Adair [Bioelectromagnetics 14:1-4, 1993] writes that "the effects of 60 Hz magnetic fields of 5 microT (50 mG) or less on biological structures holding magnetite (Fe3O4) are shown to be much smaller than those from thermal agitation; hence such interactions cannot be expected to be biologically significant." This conc...

    journal_title:Bioelectromagnetics

    pub_type: 评论,杂志文章

    doi:10.1002/bem.2250150308

    authors: Polk C

    更新日期:1994-01-01 00:00:00

  • Amplitude and frequency dissociation spectra of ion-protein complexes rotating in magnetic fields.

    abstract::A mechanism is presented that predicts new biological effects of static and sinusoidal weak magnetic fields. The model is based on an earlier proposed interference mechanism of quantum states of ions within protein cavities. The quantum dynamics of an ion is studied for the case of ion-protein complexes that rotate in...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:

    authors: Binhi VN

    更新日期:2000-01-01 00:00:00

  • Some behavioral effects of short-term exposure of rats to 2.45 GHz microwave radiation.

    abstract::Rats were tested for neurobehavioral alterations immediately after exposure to 2.45-GHz (CW) microwave radiation at 10 mW/cm2 for 7 h. Behavioral tests used were locomotor activity, startle to an acoustic stimulus and acquisition and retention of a shock-motivated passive avoidance task. Both horizontal and vertical c...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.2250090307

    authors: Mitchell CL,McRee DI,Peterson NJ,Tilson HA

    更新日期:1988-01-01 00:00:00

  • Microwave effects on the nervous system.

    abstract::Studies have evaluated the electroencephalography (EEG) of humans and laboratory animals during and after Radiofrequency (RF) exposures. Effects of RF exposure on the blood-brain barrier (BBB) have been generally accepted for exposures that are thermalizing. Low level exposures that report alterations of the BBB remai...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章,评审

    doi:10.1002/bem.10179

    authors: D'Andrea JA,Chou CK,Johnston SA,Adair ER

    更新日期:2003-01-01 00:00:00

  • New theoretical treatment of ion resonance phenomena.

    abstract::Despite experimental evidence supporting ICR-like interactions in biological systems, to date there is no reasonable theoretical explanation for this phenomenon. The parametric resonance approach introduced by Lednev has enjoyed limited success in predicting the response as a function of the ratio of AC magnetic inten...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.20406

    authors: Vincze G,Szasz A,Liboff AR

    更新日期:2008-07-01 00:00:00

  • Immunological effects of amplitude-modulated radio frequency radiation: B lymphocyte capping.

    abstract::B lymphocytes collected from normal ICR Swiss mouse spleens were exposed in vitro in a Crawford cell to 147-MHz radiofrequency (RF) radiation, amplitude modulated by a 9-, 16-, or 60-Hz sine wave. The power densities ranged between 0.11 and 48 mW/cm2. The irradiated samples and the controls were maintained at 37 degre...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.2250040206

    authors: Sultan MF,Cain CA,Tompkins WA

    更新日期:1983-01-01 00:00:00

  • Gibberellins are involved in effect of near-null magnetic field on Arabidopsis flowering.

    abstract::We previously found that flowering of Arabidopsis was suppressed by near-null magnetic field, which was related to the modification of cryptochrome. To disclose the physiological mechanism of this effect, we detected gibberellin (GA) levels and expressions of GA biosynthetic and signaling genes in wild type Arabidopsi...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.22004

    authors: Xu C,Yu Y,Zhang Y,Li Y,Wei S

    更新日期:2017-01-01 00:00:00

  • Non-thermal effects in the microwave induced unfolding of proteins observed by chaperone binding.

    abstract::We study the effect of microwaves at 2,450 MHz on protein unfolding using surface plasmon resonance sensing. Our experimental method makes use of the fact that unfolding proteins tend to bind to chaperones on their unfolding pathway and this attachment is readily monitored by surface plasmon resonance. We use the prot...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.20382

    authors: George DF,Bilek MM,McKenzie DR

    更新日期:2008-05-01 00:00:00

  • Blockade of sensory neuron action potentials by a static magnetic field in the 10 mT range.

    abstract::To characterize the inhibitory effect of a static magnetic field, action potentials (AP) were elicited by intracellular application of 1 ms depolarizing current pulses of constant amplitude to the somata of adult mouse dorsal root ganglion neurons in monolayer dissociated cell culture. During the control period, < 5% ...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.2250160108

    authors: McLean MJ,Holcomb RR,Wamil AW,Pickett JD,Cavopol AV

    更新日期:1995-01-01 00:00:00

  • Glycoproteins bound to ion channels mediate detection of electric fields: a proposed mechanism and supporting evidence.

    abstract::The mechanism by which animals detect weak electric and magnetic fields has not yet been elucidated. We propose that transduction of an electric field (E) occurs at the apical membrane of a specialized cell as a consequence of an interaction between the field and glycoproteins bound to the gates of ion channels. Accor...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.20310

    authors: Kolomytkin OV,Dunn S,Hart FX,Frilot C 2nd,Kolomytkin D,Marino AA

    更新日期:2007-07-01 00:00:00

  • Effects of millimeter waves on ionic currents of Lymnaea neurons.

    abstract::The effects of mm-waves 60.22-62.22 GHz and 75 GHz on A-type K+ currents and the effects of 61.22 GHz on Ca2+ currents of Lymnaea neurons were investigated using a whole-cell voltage-clamp technique. The open end of a rectangular waveguide covered with a thin Teflon film served as a radiator. Specific absorption rates...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:

    authors: Alekseev SI,Ziskin MC

    更新日期:1999-01-01 00:00:00

  • Carcinogenicity test in B6C3F1 mice after parental and prenatal exposure to 50 Hz magnetic fields.

    abstract::Some epidemiological studies suggest association of childhood cancer with occupational exposure of the parents to magnetic fields. To test this relationship, 50 each of C57BL/6J female and C3H/HeJ male mice were exposed for 2 and 9 weeks, respectively, to 50 Hz sham (group A), 0.5 (group B), and 5 mT (group C) sinusoi...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.10012

    authors: Otaka Y,Chida T,Yamagishi Y,Kitamura S

    更新日期:2002-04-01 00:00:00

  • Radiation from mobile phone systems: Is it perceived as a threat to people's health?

    abstract::The aim of this study was to explore the prevalence, nature and determinants of concerns about mobile phone radiation. We used data from a 2006 telephone survey of 1004 people aged 15+ years in Denmark. Twenty-eight percent of the respondents were concerned about exposure to mobile phone radiation; radiation from mast...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.20484

    authors: Kristiansen IS,Elstein AS,Gyrd-Hansen D,Kildemoes HW,Nielsen JB

    更新日期:2009-07-01 00:00:00

  • ELF magnetic fields in electric and gasoline-powered vehicles.

    abstract::We conducted a pilot study to assess magnetic field levels in electric compared to gasoline-powered vehicles, and established a methodology that would provide valid data for further assessments. The sample consisted of 14 vehicles, all manufactured between January 2000 and April 2009; 6 were gasoline-powered vehicles ...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.21730

    authors: Tell RA,Sias G,Smith J,Sahl J,Kavet R

    更新日期:2013-02-01 00:00:00

  • Morphological and electrophysiological changes produced by electrical stimulation in cultured neuroblastoma cells.

    abstract::Electric fields, which were equivalent to those generated by medical devices, were applied to cultured neuroblastoma cells (mouse and human) to test for morphological damage and to establish damage thresholds. Each of two methods of applying fields permitted flow of electrical current and minimized exposure of cells t...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.2250120505

    authors: Krauthamer V,Bekken M,Horowitz JL

    更新日期:1991-01-01 00:00:00

  • Description of a new computer wire coding method and its application to evaluate potential control selection bias in the Savitz et al. childhood cancer study.

    abstract::We developed a new computer wire coding method and then applied it to investigate the suggestion that control selection bias might explain the observed association between wire codes and childhood cancer made in the study conducted by Savitz et al. in the Denver area. The computer wire coding method used a geographic ...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:

    authors: Ebi KL,Kheifets LI,Pearson RL,Wachtel H

    更新日期:2000-07-01 00:00:00

  • Human keratinocytes in culture exhibit no response when exposed to short duration, low amplitude, high frequency (900 MHz) electromagnetic fields in a reverberation chamber.

    abstract::We exposed normal human epidermal keratinocytes to short duration, high frequency, and low amplitude electromagnetic fields, similar to that used by mobile phone technologies. We paid particular attention to the control of the characteristics of the electromagnetic environment generated within a mode stirred reverbera...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.20641

    authors: Roux D,Girard S,Paladian F,Bonnet P,Lalléchère S,Gendraud M,Davies E,Vian A

    更新日期:2011-05-01 00:00:00

  • System for the exposure of cell suspensions to power-frequency electric fields.

    abstract::A system is described that uses an oscillating magnetic field to produce power-frequency electric fields with strengths in excess of those produced in an animal or human standing under a high-voltage electric-power transmission line. In contrast to other types of exposure systems capable of generating fields of this s...

    journal_title:Bioelectromagnetics

    pub_type: 杂志文章

    doi:10.1002/bem.2250050202

    authors: Kaune WT,Frazier ME,King AJ,Samuel JE,Hungate FP,Causey SC

    更新日期:1984-01-01 00:00:00