Abstract:
:Recent evidence indicates that ethanol modulates the function of specific intracellular signaling cascades, including those that contain cyclic adenosine 3', 5'-monophosphate (cAMP)-dependent protein kinase A (PKA), protein kinase C (PKC), the tyrosine kinase Fyn, and phospholipase D (PLD). In some cases, the specific components of these cascades appear to mediate the effects of ethanol, whereas other components indirectly modify responses to ethanol. Studies utilizing selective inhibitors and genetically modified mice have identified specific isoforms of proteins involved in responses to ethanol. The effects of ethanol on neuronal signaling appear restricted to certain brain regions, partly due to the restricted distribution of these proteins. This likely contributes specificity to ethanol's actions on behavior. This review summarizes recent work on ethanol and intracellular signal transduction, emphasizing studies that have identified specific molecular events that underlie behavioral responses to ethanol.
journal_name
Pharmacol Therjournal_title
Pharmacology & therapeuticsauthors
Newton PM,Messing ROdoi
10.1016/j.pharmthera.2005.07.004subject
Has Abstractpub_date
2006-01-01 00:00:00pages
227-37issue
1-2eissn
0163-7258issn
1879-016Xpii
S0163-7258(05)00159-2journal_volume
109pub_type
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