Intracellular signaling pathways that regulate behavioral responses to ethanol.

Abstract:

:Recent evidence indicates that ethanol modulates the function of specific intracellular signaling cascades, including those that contain cyclic adenosine 3', 5'-monophosphate (cAMP)-dependent protein kinase A (PKA), protein kinase C (PKC), the tyrosine kinase Fyn, and phospholipase D (PLD). In some cases, the specific components of these cascades appear to mediate the effects of ethanol, whereas other components indirectly modify responses to ethanol. Studies utilizing selective inhibitors and genetically modified mice have identified specific isoforms of proteins involved in responses to ethanol. The effects of ethanol on neuronal signaling appear restricted to certain brain regions, partly due to the restricted distribution of these proteins. This likely contributes specificity to ethanol's actions on behavior. This review summarizes recent work on ethanol and intracellular signal transduction, emphasizing studies that have identified specific molecular events that underlie behavioral responses to ethanol.

journal_name

Pharmacol Ther

authors

Newton PM,Messing RO

doi

10.1016/j.pharmthera.2005.07.004

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

227-37

issue

1-2

eissn

0163-7258

issn

1879-016X

pii

S0163-7258(05)00159-2

journal_volume

109

pub_type

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