Abstract：
:Metabolic diseases have a tremendous impact on human morbidity and mortality. Numerous targets regulating adenosine monophosphate kinase (AMPK) have been identified for treating the metabolic syndrome (MetS), and many compounds are being used or developed to increase AMPK activity. In parallel, the cyclic nucleotide phosphodiesterase families (PDEs) have emerged as new therapeutic targets in cardiovascular diseases, as well as in non-resolved pathologies. Since some PDE subfamilies inactivate cAMP into 5'-AMP, while the beneficial effects in MetS are related to 5'-AMP-dependent activation of AMPK, an analysis of the various controversial relationships between PDEs and AMPK in MetS appears interesting. The present review will describe the various PDE families, AMPK and molecular mechanisms in the MetS and discuss the PDEs/PDE modulators related to the tissues involved, thus supporting the discovery of original molecules and the design of new therapeutic approaches in MetS.
journal_name
Pharmacol Therjournal_title
Pharmacology & therapeuticsauthors
Lugnier C,Meyer A,Talha S,Geny Bdoi
10.1016/j.pharmthera.2020.107475subject
Has Abstractpub_date
2020-04-01 00:00:00pages
107475eissn
0163-7258issn
1879-016Xpii
S0163-7258(20)30003-6journal_volume
208pub_type
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