Structure-function relationships of acid ribonucleases: lysosomal, vacuolar, and periplasmic enzymes.

Abstract:

:It is surprising that only relatively recently has attention been directed to the characterization of the properties of acid ribonucleases (RNases), leading to some understanding of their biochemistry and their functional roles. The present review summarizes current progress in this field under the following general topics: (1) the wide distribution of acid RNases in organisms from viruses to animals; (2) recent findings concerning their primary and three-dimensional structure; (3) the structure-function relationship of acid RNases, with a fungal RNase from Rhizopus niveus as a model enzyme; (4) the unique localization of acid RNases in the periplasm of bacteria, vacuoles in plants, and lysosomes of animals and protozoa; and (5) the diversity of physiological roles, depending on the organism, such as self-incompatibility factors and defense proteins in some plants, the surface protein of an animal virus related to pathogenicity, and possible relationship to human cancer.

journal_name

Pharmacol Ther

authors

Irie M

doi

10.1016/s0163-7258(98)00035-7

subject

Has Abstract

pub_date

1999-02-01 00:00:00

pages

77-89

issue

2

eissn

0163-7258

issn

1879-016X

pii

S0163-7258(98)00035-7

journal_volume

81

pub_type

杂志文章,评审
  • Cardiac oxidative stress in diabetes: Mechanisms and therapeutic potential.

    abstract::Macrovascular complications of diabetes, including diabetic cardiovascular disease (CVD), occur through a number of hyperglycaemia-induced mechanisms that include generation of oxidative stress, accumulation of advanced glycation end-products (AGE) and activation of protein kinase C (PKC). Cardiac oxidative stress is ...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2016.11.013

    authors: Faria A,Persaud SJ

    更新日期:2017-04-01 00:00:00

  • MERTK in cancer therapy: Targeting the receptor tyrosine kinase in tumor cells and the immune system.

    abstract::The receptor tyrosine kinase MERTK is aberrantly expressed in numerous human malignancies, and is a novel target in cancer therapeutics. Physiologic roles of MERTK include regulation of tissue homeostasis and repair, innate immune control, and platelet aggregation. However, aberrant expression in a wide range of liqui...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2020.107577

    authors: Huelse JM,Fridlyand DM,Earp S,DeRyckere D,Graham DK

    更新日期:2020-09-01 00:00:00

  • The role of transporters in cellular heme and porphyrin homeostasis.

    abstract::Heme, a complex of iron and protoporphyrin IX (PPIX), senses and utilizes oxygen in nearly all living cells. It is an essential component of various hemoproteins, including those involved in oxygen transport and storage (hemoglobin, myoglobin), electron transfer, drug and steroid metabolism (cytochromes), and signal t...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2007.02.001

    authors: Krishnamurthy P,Xie T,Schuetz JD

    更新日期:2007-06-01 00:00:00

  • Pharmacological aspects of anticancer drug-induced emesis with emphasis on serotonin release and vagal nerve activity.

    abstract::Cytotoxic drug-induced nausea and vomiting are the side effects most feared by cancer patients. Emesis is an instinctive defense reaction caused by the somatoautonomic nerve reflex, which is integrated in the medulla oblongata. Emesis caused by cytotoxic drugs such as cisplatin is associated with an increase in the co...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/s0163-7258(03)00057-3

    authors: Minami M,Endo T,Hirafuji M,Hamaue N,Liu Y,Hiroshige T,Nemoto M,Saito H,Yoshioka M

    更新日期:2003-08-01 00:00:00

  • Allosteric pathways in nuclear receptors - Potential targets for drug design.

    abstract::The nuclear receptor family of transcription factor proteins mediates endocrine function and plays critical roles in the development, physiology and pharmacology. Malfunctioning nuclear receptors are associated with several disease states. The functional activity of nuclear receptors is regulated by small molecular ho...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2017.10.014

    authors: Fernandez EJ

    更新日期:2018-03-01 00:00:00

  • G-protein-coupled receptor dimerization: modulation of receptor function.

    abstract::G-protein-coupled receptors (GPCRs) comprise the largest family of transmembrane receptors in the human genome that respond to a plethora of signals, including neurotransmitters, peptide hormones, and odorants, to name a few. They couple to second messenger signaling cascade mechanisms via heterotrimeric G-proteins. R...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/s0163-7258(01)00160-7

    authors: Rios CD,Jordan BA,Gomes I,Devi LA

    更新日期:2001-11-01 00:00:00

  • Cytokine gene-modified vaccines in the therapy of cancer.

    abstract::Therapeutic strategies based on the insertion of cytokine genes into the genome of tumour cells, followed by vaccination with the resulting genetically modified, cytokine-producing cells, represent a new potential prospect for treatment of cancer patients. In this review, the concept of cytokine gene-modified cancer v...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/0163-7258(95)02016-0

    authors: Bubenik J

    更新日期:1996-01-01 00:00:00

  • Pharmacological modulation of cholesteryl ester transfer protein, a new therapeutic target in atherogenic dyslipidemia.

    abstract::In mediating the transfer of cholesteryl esters (CE) from antiatherogenic high density lipoprotein (HDL) to proatherogenic apolipoprotein (apo)-B-containing lipoprotein particles (including very low density lipoprotein [VLDL], VLDL remnants, intermediate density lipoprotein [IDL], and low density lipoprotein [LDL]), t...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2003.10.001

    authors: Le Goff W,Guerin M,Chapman MJ

    更新日期:2004-01-01 00:00:00

  • Protein kinase inhibitors and antibiotic resistance.

    abstract::While antibiotics revolutionized the treatment of infectious disease in the 20th century, bacterial resistance now threatens to render many of them ineffective. Aminoglycosides are a class of clinically important antibiotics used in the treatment of infections caused by Gram-positive and -negative organisms. They are ...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/s0163-7258(02)00197-3

    authors: Burk DL,Berghuis AM

    更新日期:2002-02-01 00:00:00

  • The sigma-1 receptor as a regulator of dopamine neurotransmission: A potential therapeutic target for methamphetamine addiction.

    abstract::Methamphetamine (METH) abuse is a major public health issue around the world, yet there are currently no effective pharmacotherapies for the treatment of METH addiction. METH is a potent psychostimulant that increases extracellular dopamine levels by targeting the dopamine transporter (DAT) and alters neuronal activit...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2018.01.009

    authors: Sambo DO,Lebowitz JJ,Khoshbouei H

    更新日期:2018-06-01 00:00:00

  • Strategies to generate functionally normal neutrophils to reduce infection and infection-related mortality in cancer chemotherapy.

    abstract::Neutrophils form an essential part of innate immunity against infection. Cancer chemotherapy-induced neutropenia (CCIN) is a condition in which the number of neutrophils in a patient's bloodstream is decreased, leading to increased susceptibility to infection. Granulocyte colony-stimulating factor (GCSF) has been the ...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2019.107403

    authors: Abdel-Azim H,Sun W,Wu L

    更新日期:2019-12-01 00:00:00

  • The 90-kDa molecular chaperone family: structure, function, and clinical applications. A comprehensive review.

    abstract::The 90-kDa molecular chaperone family (which comprises, among other proteins, the 90-kDa heat-shock protein, hsp90 and the 94-kDa glucose-regulated protein, grp94, major molecular chaperones of the cytosol and of the endoplasmic reticulum, respectively) has become an increasingly active subject of research in the past...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/s0163-7258(98)00013-8

    authors: Csermely P,Schnaider T,Soti C,Prohászka Z,Nardai G

    更新日期:1998-08-01 00:00:00

  • Calcitonin gene-related peptide: multiple actions, multiple receptors.

    abstract::Calcitonin gene-related peptide (CGRP) shows diversity both in its effects and its receptors. It is likely to have roles as a neurotransmitter, neuromodulator, local hormone and trophic factor. Its effects include rapid changes in neuronal activity, relaxation of many types of smooth muscle, actions on metabolism and ...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/0163-7258(92)90036-y

    authors: Poyner DR

    更新日期:1992-01-01 00:00:00

  • Anti-oxidative, anti-cancer and anti-inflammatory actions by thioredoxin 1 and thioredoxin-binding protein-2.

    abstract::Thioredoxin 1 (Trx 1) is a 12-kDa protein with redox-active dithiol in the active site -Cys-Gly-Pro-Cys- that is ubiquitously present in the human body. Trx 1 is a defensive protein induced by various stresses and has anti-oxidative, anti-apoptotic and anti-inflammatory effects. The anti-oxidative effect of Trx 1 is m...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2010.04.004

    authors: Watanabe R,Nakamura H,Masutani H,Yodoi J

    更新日期:2010-09-01 00:00:00

  • Exercise and endothelial function: role of endothelium-derived nitric oxide and oxidative stress in healthy subjects and hypertensive patients.

    abstract::Recent epidemiologic studies have shown that aerobic exercise, one of lifestyle modifications, reduces cardiovascular morbidity and mortality in the general population. However, the mechanisms underlying the anti-atherogenic and anti-hypertensive effects of exercise remain unclear. Hypertension is associated with alte...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2004.02.003

    authors: Higashi Y,Yoshizumi M

    更新日期:2004-04-01 00:00:00

  • Extracellular vesicles in cancer diagnostics and therapeutics.

    abstract::Cancer promotion, development, and malignant transformation is greatly influenced by cell-to-cell interactions in a complex tissue microenvironment. Cancer and stromal cells secrete soluble factors, as well as deport membrane-encapsulated structures, which actively contribute and mediate cell-to-cell interaction withi...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2021.107806

    authors: Shehzad A,Islam SU,Shahzad R,Khan S,Lee YS

    更新日期:2021-01-16 00:00:00

  • Challenges and achievements in the therapeutic modulation of aquaporin functionality.

    abstract::Aquaporin (AQP) water and solute channels have basic physiological functions throughout the human body. AQP-facilitated water permeability across cell membranes is required for rapid reabsorption of water from pre-urine in the kidneys and for sustained near isosmolar water fluxes e.g. in the brain, eyes, inner ear, an...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2015.08.002

    authors: Beitz E,Golldack A,Rothert M,von Bülow J

    更新日期:2015-11-01 00:00:00

  • Role of nitrergic system in behavioral and neurotoxic effects of amphetamine analogs.

    abstract::Several amphetamine analogs are potent psychostimulants and major drugs of abuse. In animal models, the psychomotor and reinforcing effects of amphetamine, methamphetamine (METH), 3,4-methylenedioxymethamphetamine (MDMA; Ecstasy), and methylphenidate (MPD; Ritalin) are thought to be dependent on increased extracellula...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2005.08.004

    authors: Itzhak Y,Ali SF

    更新日期:2006-01-01 00:00:00

  • Challenges to congenital genetic disorders with "RNA-targeting" chemical compounds.

    abstract::Patients of congenital diseases such as Down syndrome (DS) and Duchenne muscular dystrophy (DMD) have abnormalities in their chromosomes and/or genes. Therefore, it has been considered that drug treatments can serve to do little for these patients more than to patch over each symptom temporarily when it arises. Althou...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2012.02.001

    authors: Ogawa Y,Hagiwara M

    更新日期:2012-06-01 00:00:00

  • Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells?

    abstract::Canonical Wnt signaling is a highly conserved pathway with a prominent role in embryogenic development, adult tissue homeostasis, cell polarization, stem cell biology, cell differentiation, and proliferation. Furthermore, canonical Wnt signaling is of pivotal importance in the pathogenesis of a number of cancer types ...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2015.11.001

    authors: Roos J,Grösch S,Werz O,Schröder P,Ziegler S,Fulda S,Paulus P,Urbschat A,Kühn B,Maucher I,Fettel J,Vorup-Jensen T,Piesche M,Matrone C,Steinhilber D,Parnham MJ,Maier TJ

    更新日期:2016-01-01 00:00:00

  • New hope for cancer treatment: exploring the distinction between normal adult stem cells and cancer stem cells.

    abstract::For decades, intensive studies have attempted to identify the mechanisms underlying malignant tumor growth. Despite significant progress, most therapeutic approaches fail to eliminate all tumor cells. The remaining tumor cells often result in recurrence and metastasis. Recently, the idea of a cancer stem cell was prop...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2008.04.008

    authors: Zhao RC,Zhu YS,Shi Y

    更新日期:2008-07-01 00:00:00

  • Pluripotent stem cell differentiation into vascular cells: a novel technology with promises for vascular re(generation).

    abstract::Several types of stem and progenitor cells are currently under investigation for their potential to accomplish vascular regeneration. This review focuses on embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). We will discuss the technologies allowing for their derivation, culture expansion and main...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2010.10.004

    authors: Kane NM,Xiao Q,Baker AH,Luo Z,Xu Q,Emanueli C

    更新日期:2011-01-01 00:00:00

  • Therapeutic targets in pulmonary arterial hypertension.

    abstract::Pulmonary arterial hypertension is a progressive, fatal disease. Current treatments including prostanoids, endothelin-1 (ET-1) antagonists, and phosphodiesterase (PDE) inhibitors, have sought to address the pulmonary vascular endothelial dysfunction and vasoconstriction associated with the condition. These treatments ...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2008.10.002

    authors: Rhodes CJ,Davidson A,Gibbs JS,Wharton J,Wilkins MR

    更新日期:2009-01-01 00:00:00

  • Preventing asthma exacerbations: what are the targets?

    abstract::Exacerbations of asthma are the main cause of asthma morbidity. They induce acute respiratory failure, and sometimes death. Two immunological signals acting in synergy are necessary for inducing asthma exacerbations. The first, triggered by allergens and/or unknown agents leads to the chronic Th2 inflammation characte...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2011.03.010

    authors: Botturi K,Langelot M,Lair D,Pipet A,Pain M,Chesne J,Hassoun D,Lacoeuille Y,Cavaillès A,Magnan A

    更新日期:2011-07-01 00:00:00

  • K(+) channels as therapeutic drug targets.

    abstract::K(+) channels play critical roles in a wide variety of physiological processes, including the regulation of heart rate, muscle contraction, neurotransmitter release, neuronal excitability, insulin secretion, epithelial electrolyte transport, cell volume regulation, and cell proliferation. As such, K(+) channels have b...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/s0163-7258(02)00201-2

    authors: Wickenden A

    更新日期:2002-04-01 00:00:00

  • Regulations of opioid dependence by opioid receptor types.

    abstract::Three major types of opioid receptors, designated mu, delta, and kappa, are widely expressed in the CNS. Development of selective receptor ligands and recent cloning of each receptor have contributed greatly to our increasing knowledge of the neuropharmacological profile of each opioid receptor type. It is of interest...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/s0163-7258(00)00099-1

    authors: Narita M,Funada M,Suzuki T

    更新日期:2001-01-01 00:00:00

  • Carcinogen-mediated oxidant formation and oxidative DNA damage.

    abstract::This article reviews the experimental data that points to formation of reactive oxygen species (ROS) and oxidative DNA base damage as being important contributors to cancer development. Particular emphasis is placed on the role they play in genetic changes occurring during tumor promotion. A number of structurally dif...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/0163-7258(92)90047-4

    authors: Frenkel K

    更新日期:1992-01-01 00:00:00

  • Molecular mechanism of retroviral DNA integration.

    abstract::The integration of retroviral DNA appears to be obligatory for the efficient replication of retroviruses in their respective host cells. During a natural infection, integration takes place in a process that includes biochemically and temporally discrete steps. These are: (1) the removal of two nucleotides from the 3' ...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/0163-7258(94)90062-0

    authors: Kulkosky J,Skalka AM

    更新日期:1994-01-01 00:00:00

  • Immunotherapy in sepsis - brake or accelerate?

    abstract::Sepsis, a life threating syndrome characterized by organ failure after infection, is the most common cause of death in hospitalized patients. The treatment of sepsis is generally supportive in nature, involving the administration of intravenous fluids, vasoactive substances and oxygen plus antibiotics to eliminate the...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2020.107476

    authors: Steinhagen F,Schmidt SV,Schewe JC,Peukert K,Klinman DM,Bode C

    更新日期:2020-04-01 00:00:00

  • The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target.

    abstract::Type I signal peptidases are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are translocated across biological membranes. The bacterial signal peptidases are unique serine proteases that utilize a Ser/Lys catalytic dyad mechanism in plac...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1016/s0163-7258(00)00064-4

    authors: Paetzel M,Dalbey RE,Strynadka NC

    更新日期:2000-07-01 00:00:00