Molecular events in adipocyte development.

Abstract:

:Adipocyte hyperplasia occurs by the proliferation and differentiation of adipocyte precursor cells or preadipocytes. Although the process of commitment to the adipocyte lineage is poorly understood, a great deal of information has accumulated about the processes and regulatory mechanisms involved in preadipocyte differentiation. The differentiation of preadipocytes is known to be characterized by increased transcription of a number of specific genes. AP-1 and C/EBP binding sites within these genes have been identified as important regulatory sequences. In addition, a specific enhancer sequence has been shown to confer adipose tissue specificity. This article will review the changes in gene transcription that occur during preadipocyte differentiation and how these are regulated. The potential role of autocrine/paracrine acting factors in the proliferation and differentiation of the preadipocyte is also discussed.

journal_name

Pharmacol Ther

authors

Butterwith SC

doi

10.1016/0163-7258(94)90018-3

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

399-411

issue

3

eissn

0163-7258

issn

1879-016X

pii

0163-7258(94)90018-3

journal_volume

61

pub_type

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