Abstract:
:Angiotensin II (Ang II) is the main effector hormone of the renin-angiotensin system (RAS). The pathogenesis of many cardiovascular diseases, including heart failure and hypertension, appear to be related to Ang II production. The generation of Ang II involves angiotensin-converting enzyme (ACE) in circulating and tissue RAS's, as well as non-ACE pathways. ACE and other components of the RAS show natural mutations. In this review, we discuss the molecular genetics of the human RAS in relation to cardiovascular disease, including the clinical effects of known ACE molecular variants and possible pharmacological treatment strategies.
journal_name
Pharmacol Therjournal_title
Pharmacology & therapeuticsauthors
Davis GK,Roberts DHdoi
10.1016/s0163-7258(97)00021-1subject
Has Abstractpub_date
1997-01-01 00:00:00pages
43-50issue
1eissn
0163-7258issn
1879-016Xpii
S0163-7258(97)00021-1journal_volume
75pub_type
杂志文章,评审abstract::Thyroid hormone (TH) is essential for normal brain development and may also promote recovery and neuronal regeneration after brain injury. TH acts predominantly through the nuclear receptors, TH receptor alpha (THRA) and beta (THRB). Additional factors that impact TH action in the brain include metabolism, activation ...
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
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journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
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journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
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journal_title:Pharmacology & therapeutics
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doi:10.1016/j.pharmthera.2010.08.010
更新日期:2010-12-01 00:00:00
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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doi:10.1016/j.pharmthera.2017.10.010
更新日期:2018-03-01 00:00:00
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journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
doi:10.1016/0163-7258(92)90015-r
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pub_type: 共识发展会议,杂志文章,评审
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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更新日期:2012-12-01 00:00:00
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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更新日期:2013-03-01 00:00:00
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journal_title:Pharmacology & therapeutics
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