Abstract：
:The 90-kDa molecular chaperone family (which comprises, among other proteins, the 90-kDa heat-shock protein, hsp90 and the 94-kDa glucose-regulated protein, grp94, major molecular chaperones of the cytosol and of the endoplasmic reticulum, respectively) has become an increasingly active subject of research in the past couple of years. These ubiquitous, well-conserved proteins account for 1-2% of all cellular proteins in most cells. However, their precise function is still far from being elucidated. Their involvement in the aetiology of several autoimmune diseases, in various infections, in recognition of malignant cells, and in antigen-presentation already demonstrates the essential role they likely will play in clinical practice of the next decade. The present review summarizes our current knowledge about the cellular functions, expression, and clinical implications of the 90-kDa molecular chaperone family and some approaches for future research.
journal_name
Pharmacol Therjournal_title
Pharmacology & therapeuticsauthors
Csermely P,Schnaider T,Soti C,Prohászka Z,Nardai Gdoi
10.1016/s0163-7258(98)00013-8subject
Has Abstractpub_date
1998-08-01 00:00:00pages
129-68issue
2eissn
0163-7258issn
1879-016Xpii
S0163725898000138journal_volume
79pub_type
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journal_title：Pharmacology & therapeutics
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journal_title：Pharmacology & therapeutics
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journal_title：Pharmacology & therapeutics
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journal_title：Pharmacology & therapeutics
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journal_title：Pharmacology & therapeutics
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journal_title：Pharmacology & therapeutics
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journal_title：Pharmacology & therapeutics
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journal_title：Pharmacology & therapeutics
pub_type： 杂志文章,评审
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journal_title：Pharmacology & therapeutics
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journal_title：Pharmacology & therapeutics
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更新日期：1995-01-01 00:00:00
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更新日期：2007-11-01 00:00:00
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journal_title：Pharmacology & therapeutics
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更新日期：2014-11-01 00:00:00
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journal_title：Pharmacology & therapeutics
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doi：10.1016/0163-7258(92)90036-y
更新日期：1992-01-01 00:00:00
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journal_title：Pharmacology & therapeutics
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更新日期：2012-09-01 00:00:00
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更新日期：2007-06-01 00:00:00
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journal_title：Pharmacology & therapeutics
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更新日期：2018-06-01 00:00:00
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journal_title：Pharmacology & therapeutics
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journal_title：Pharmacology & therapeutics
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journal_title：Pharmacology & therapeutics
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journal_title：Pharmacology & therapeutics
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journal_title：Pharmacology & therapeutics
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journal_title：Pharmacology & therapeutics
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journal_title：Pharmacology & therapeutics
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journal_title：Pharmacology & therapeutics
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doi：10.1016/j.pharmthera.2020.107712
更新日期：2020-10-27 00:00:00
abstract：:5-Lipoxygenase (5-LO) catalyzes the conversion of arachidonic acid (AA) into leukotriene (LT) A(4) and 5-hydroperoxyeicosatetraenoic acid. LTA(4) can then be converted into LTB(4) by LTA(4) hydrolase or into LTC(4) by LTC(4) synthase and the LTC(4) synthase isoenzymes MGST2 and MGST3. LTB(4) is a potent chemoattractan...
journal_title：Pharmacology & therapeutics
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更新日期：2006-12-01 00:00:00
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journal_title：Pharmacology & therapeutics
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更新日期：2018-03-01 00:00:00
abstract：:In the 1980s, Bowery and colleagues discovered the presence of a novel, bicuculline-resistant and baclofen-sensitive type of GABA receptor on peripheral nerve terminals, the GABA(B) receptor. Since this pioneering work, GABA(B) receptors have been identified in the Central Nervous System (CNS), where they provide an i...
journal_title：Pharmacology & therapeutics
pub_type： 杂志文章,评审
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更新日期：2011-11-01 00:00:00
abstract：:Since the first reports on chemokine function, much information has been generated on the implications of these molecules in numerous physiological and pathological processes, as well as on the signaling events activated through their binding to receptors. Despite these extensive studies, no chemokine-related drugs ha...
journal_title：Pharmacology & therapeutics
pub_type： 杂志文章,评审
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更新日期：2011-09-01 00:00:00
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journal_title：Pharmacology & therapeutics
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更新日期：2004-01-01 00:00:00
