Abstract：
:The "late sodium current" (I(NaL)) is a sustained component of the fast Na+ current of cardiac myocytes and neurons. As recently appreciated, common neurological and cardiac conditions are associated with abnormal I(NaL) enhancement, which may contribute to the pathogenesis of both electrical and contractile dysfunction. For this reason, I(NaL) has become an appealing pharmacological target, with a potentially broad range of therapeutic indications. The recent approval by the FDA of an I(NaL) blocker (ranolazine) for clinical use justifies the increased interest in I(NaL) as a pathogenic mechanism and the rapid evolution of the information concerning it. The review focuses on cardiac aspects of I(NaL) enhancement; it deals with the origin of I(NaL), with its pathophysiological role and with the consequences of its pharmacological modulation. Both basic aspects and clinical evidence are discussed.
journal_name
Pharmacol Therjournal_title
Pharmacology & therapeuticsauthors
Zaza A,Belardinelli L,Shryock JCdoi
10.1016/j.pharmthera.2008.06.001subject
Has Abstractpub_date
2008-09-01 00:00:00pages
326-39issue
3eissn
0163-7258issn
1879-016Xpii
S0163-7258(08)00108-3journal_volume
119pub_type
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