Endothelins and sarafotoxins: physiological regulation, receptor subtypes and transmembrane signaling.

Abstract:

:The endothelins and sarafotoxins are two structurally related families of potent vasoactive peptides. Although the physiological functions of these peptides are not entirely clear, the endothelins are probably involved in pathophysiological conditions such as hypertension and heart failure. This review summarizes the state of the art in some areas of this intensively studied subject, including: (1) structure-function relationships of ET/SRTX, (2) ET concentrations in plasma, (3) ET/SRTX receptor subtypes and (4) signaling events mediated by the activation of ET/SRTX receptors.

journal_name

Pharmacol Ther

authors

Sokolovsky M

doi

10.1016/0163-7258(92)90030-4

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

129-49

issue

2

eissn

0163-7258

issn

1879-016X

pii

0163-7258(92)90030-4

journal_volume

54

pub_type

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