Abstract:
:Postoperative atrial fibrillation (POAF) is a common complication of cardiac surgery that occurs in up to 60% of patients. POAF is associated with increased risk of cardiovascular mortality, stroke and other arrhythmias that can impact on early and long term clinical outcomes and health economics. Many factors such as disease-induced cardiac remodelling, operative trauma, changes in atrial pressure and chemical stimulation and reflex sympathetic/parasympathetic activation have been implicated in the development of POAF. There is mounting evidence to support a major role for inflammation and oxidative stress in the pathogenesis of POAF. Both are consequences of using cardiopulmonary bypass and reperfusion following ischaemic cardioplegic arrest. Subsequently, several anti-inflammatory and antioxidant drugs have been tested in an attempt to reduce the incidence of POAF. However, prevention remains suboptimal and thus far none of the tested drugs has provided sufficient efficacy to be widely introduced in clinical practice. A better understanding of the cellular and molecular mechanisms responsible for the onset and persistence of POAF is needed to develop more effective prediction and interventions.
journal_name
Pharmacol Therjournal_title
Pharmacology & therapeuticsauthors
Zakkar M,Ascione R,James AF,Angelini GD,Suleiman MSdoi
10.1016/j.pharmthera.2015.06.009subject
Has Abstractpub_date
2015-10-01 00:00:00pages
13-20eissn
0163-7258issn
1879-016Xpii
S0163-7258(15)00124-2journal_volume
154pub_type
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