Abstract：
:Binge-eating disorder (BED) is the most prevalent eating disorder with estimates of 2-5% of the general adult population. Nonetheless, its pathophysiology is poorly understood. Furthermore, there exist few therapeutic options for its effective treatment. Here we review the current state of binge-eating neurobiology and pharmacology, drawing from clinical therapeutic, neuroimaging, cognitive, human genetic and animal model studies. These studies, which are still in their infancy, indicate that while there are many gaps in our knowledge, several key neural substrates appear to underpin binge-eating and may be conserved between human and animals. This observation suggests that behavioral intermediate phenotypes or endophenotypes relevant to BED may be modeled in animals, facilitating the identification and testing of novel pharmacological targets. The development of novel, safe and effective pharmacological therapies for the treatment of BED will enhance the ability of clinicians to provide optimal care for people with BED.
journal_name
Pharmacol Therjournal_title
Pharmacology & therapeuticsauthors
Hutson PH,Balodis IM,Potenza MNdoi
10.1016/j.pharmthera.2017.08.002subject
Has Abstractpub_date
2018-02-01 00:00:00pages
15-27eissn
0163-7258issn
1879-016Xpii
S0163-7258(17)30212-7journal_volume
182pub_type
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