Abstract：
:The vascular Na+ pump maintains intracellular ionic concentration and controls membrane potential. Its inhibition by cardiac glycosides enhances the intracellular Na+ concentration. This in turn activates the Na+-Ca2+ exchange mechanism, which induces intracellular Ca2+ increase, membrane depolarization, and noradrenaline release from perivascular adrenergic nerve endings; mechanisms that promote vasoconstriction. This article reviews the relevance of the Na+ pump in vascular tone regulation and the modulation of its activity by the endothelium. The endothelium negatively modulates the vasoconstriction elicited by Na+ pump inhibition by the release of nitric oxide, according to some authors, or an unknown factor, as suggested by others. The possible existence of endogenous digitalis-like factors is also reviewed, as is the involvement of the vascular Na+ pump in some cardiovascular disorders and aging.
journal_name
Pharmacol Therjournal_title
Pharmacology & therapeuticsauthors
Marín J,Redondo Jdoi
10.1016/s0163-7258(99)00037-6subject
Has Abstractpub_date
1999-12-01 00:00:00pages
249-71issue
3eissn
0163-7258issn
1879-016Xpii
S0163725899000376journal_volume
84pub_type
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