Neuroimmune communication in hypertension and obesity: a new therapeutic angle?

Abstract:

:Hypertension is an epidemic health concern and a major risk factor for the development of cardiovascular disease. Although there are available treatment strategies for hypertension, numerous hypertensive patients do not have their clinical symptoms under control and it is imperative that new avenues to treat or prevent high blood pressure in these patients are developed. It is well established that increases in sympathetic nervous system (SNS) outflow and enhanced renin-angiotensin system (RAS) activity are common features of hypertension and various pathological conditions that predispose individuals to hypertension. More recently, hypertension has also become recognized as an immune condition and accumulating evidence suggests that interactions between the RAS, SNS and immune systems play a role in blood pressure regulation. This review summarizes what is known about the interconnections between the RAS, SNS and immune systems in the neural regulation of blood pressure. Based on the reviewed studies, a model for RAS/neuroimmune interactions during hypertension is proposed and the therapeutic potential of targeting RAS/neuroimmune interactions in hypertensive patients is discussed. Special emphasis is placed on the applicability of the proposed model to obesity-related hypertension.

journal_name

Pharmacol Ther

authors

de Kloet AD,Krause EG,Shi PD,Zubcevic J,Raizada MK,Sumners C

doi

10.1016/j.pharmthera.2013.02.005

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

428-40

issue

3

eissn

0163-7258

issn

1879-016X

pii

S0163-7258(13)00046-6

journal_volume

138

pub_type

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