Abstract:
:G protein-coupled receptors (GPCR) interact not only with heterotrimeric G proteins but also with accessory proteins called GPCR interacting proteins (GIP). These proteins have important functions. They are implicated in GPCR targeting to specific cellular compartments, in their assembling into large functional complexes called "receptosomes," in their trafficking to and from the plasma membrane, and in the fine-tuning of their signaling properties. There are several types of GIPs. Some are transmembrane proteins such as another GPCR (homodimerization and heterodimerization), ionic channels, ionotropic receptors, and single transmembrane proteins. The latter is implicated in the fine-tuning of receptor pharmacology or signaling. Other GIPs are soluble proteins interacting mainly with the "magic" C-terminal tail. Among them, PDZ domain-containing proteins are the most abundant. They generally, but not always, interact with the extreme C-terminal domain of GPCRs. Some GIPs interact with specific sequences of the C-terminal such as the Homer binding sequence (-PPxxFR-), the dopamine receptor interacting protein (DRIP) binding sequence (-FxxxFxxxF-), etc. Finally, only few GIPs have been found thus far to interact with the third intracellular loop of GPCRs. The future will tell us if this situation is only due to technical reasons.
journal_name
Pharmacol Therjournal_title
Pharmacology & therapeuticsauthors
Bockaert J,Fagni L,Dumuis A,Marin Pdoi
10.1016/j.pharmthera.2004.06.004subject
Has Abstractpub_date
2004-09-01 00:00:00pages
203-21issue
3eissn
0163-7258issn
1879-016Xpii
S0163-7258(04)00100-7journal_volume
103pub_type
杂志文章,评审abstract::Microsomal P450-mediated monooxygenase activity supported by NADPH requires an interaction between flavoprotein NADPH-cytochrome P450 reductase and cytochrome P450. These proteins have been identified as the simplest system (with the inclusion of a phospholipid (PL) component) that possesses monooxygenase function; ho...
journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
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abstract::Cyclooxygenase (COX) enzymes, or prostaglandin-endoperoxide synthases (PTGS), are heme-containing bis-oxygenases that catalyze the first committed reaction in metabolism of arachidonic acid (AA) to the potent lipid mediators, prostanoids and thromboxanes. Two isozymes of COX enzymes (COX-1 and COX-2) have been identif...
journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
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abstract::For many years, acid-suppressive therapy has been at the forefront of treating gastroesophageal reflux disease (GERD), yet despite the advent of the proton pump inhibitors (PPIs) some patients continue to experience persistent GERD symptoms. Therapeutic (non-surgical) options for such patients are currently limited. T...
journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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更新日期:2002-08-01 00:00:00
abstract::Progranulin (PGRN) is abundantly expressed in epithelial cells, immune cells, neurons, and chondrocytes, and reportedly contributes to tumorigenesis. PGRN is a crucial mediator of wound healing and tissue repair. PGRN also functions as a neurotrophic factor and mutations in the PGRN gene resulting in partial loss of t...
journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
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journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
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更新日期:1990-01-01 00:00:00
abstract::The receptors involved in bitter taste perception (bitter taste receptors--T2Rs) constitute a family of G-protein-coupled receptors, of which around 29 subtypes have been identified in humans. T2R expression was initially thought to be confined to the oral cavity but has recently been described in a range of other tis...
journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
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更新日期:2015-11-01 00:00:00
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journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
doi:10.1016/j.pharmthera.2007.06.002
更新日期:2007-09-01 00:00:00
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journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
doi:10.1016/j.pharmthera.2009.09.002
更新日期:2009-12-01 00:00:00
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journal_title:Pharmacology & therapeutics
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更新日期:1999-12-01 00:00:00
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journal_title:Pharmacology & therapeutics
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doi:10.1016/s0163-7258(03)00015-9
更新日期:2003-04-01 00:00:00
abstract::New techniques for the analysis of proteins with specific binding for natural retinoids in human plasma and skin extracts have been developed. Polyacrylamide gel electrophoresis (PAGE), followed by protein blotting with an antiserum specific to retinol-binding protein (RBP), the plasma carrier of retinol, showed that:...
journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
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更新日期:1989-01-01 00:00:00
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journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
doi:10.1016/j.pharmthera.2006.06.003
更新日期:2006-12-01 00:00:00
abstract::Evidence from experimental and clinical studies suggests the involvement of the endogenous opioid system in several neurologic and psychiatric disorders (Alzheimer's, Huntington's and Parkinson's diseases, drug-induced movement disorders, Gilles de la Tourette syndrome, stroke, ischemia, brain and spinal cord injury, ...
journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
doi:10.1016/0163-7258(90)90026-x
更新日期:1990-01-01 00:00:00
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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更新日期:2010-04-01 00:00:00
abstract::The RNA-dependent P1/eIF-2 alpha protein kinase is a highly specific protein-serine/threonine kinase that catalyzes the phosphorylation of the alpha subunit of protein synthesis initiation factor eIF-2. The kinase plays a central role in translational control. The activity of the kinase is regulated by a variety of na...
journal_title:Pharmacology & therapeutics
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abstract::gamma-Aminobutyric acid (GABA)A receptors for the inhibitory neurotransmitter GABA are likely to be found on most, if not all, neurons in the brain and spinal cord. They appear to be the most complicated of the superfamily of ligand-gated ion channels in terms of the large number of receptor subtypes and also the vari...
journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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更新日期:2002-02-01 00:00:00
abstract::Binge-eating disorder (BED) is the most prevalent eating disorder with estimates of 2-5% of the general adult population. Nonetheless, its pathophysiology is poorly understood. Furthermore, there exist few therapeutic options for its effective treatment. Here we review the current state of binge-eating neurobiology an...
journal_title:Pharmacology & therapeutics
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doi:10.1016/j.pharmthera.2017.08.002
更新日期:2018-02-01 00:00:00
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journal_title:Pharmacology & therapeutics
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更新日期:2019-02-01 00:00:00
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journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
doi:10.1016/j.pharmthera.2004.11.009
更新日期:2005-05-01 00:00:00
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journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
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更新日期:2015-05-01 00:00:00
abstract::Experimental and clinical studies suggest that the central and peripheral benzodiazepine (BDZ) receptors together with their ligands form the molecular basis of a novel regulatory network that contributes to the effects of anxiety on immune status. The peripheral-type receptors located on phagocytes and glial cells ap...
journal_title:Pharmacology & therapeutics
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更新日期:1997-09-01 00:00:00
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journal_title:Pharmacology & therapeutics
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更新日期:2015-12-01 00:00:00