Synaptic plasticity and phosphorylation.

Abstract:

:A number of neuronal functions, including synaptic plasticity, depend on proper regulation of synaptic proteins, many of which can be rapidly regulated by phosphorylation. Neuronal activity controls the function of these synaptic proteins by exquisitely regulating the balance of various protein kinase and protein phosphatase activity. Recent understanding of synaptic plasticity mechanisms underscores important roles that these synaptic phosphoproteins play in regulating both pre- and post-synaptic functions. This review will focus on key postsynaptic phosphoproteins that have been implicated to play a role in synaptic plasticity.

journal_name

Pharmacol Ther

authors

Lee HK

doi

10.1016/j.pharmthera.2006.06.003

subject

Has Abstract

pub_date

2006-12-01 00:00:00

pages

810-32

issue

3

eissn

0163-7258

issn

1879-016X

pii

S0163-7258(06)00119-7

journal_volume

112

pub_type

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