VMAT2 inhibitors for the treatment of hyperkinetic movement disorders.

Abstract:

:Hyperkinetic movement disorders comprise a variety of conditions characterized by involuntary movements, which include but are not limited to tardive dyskinesia, chorea associated with Huntington's Disease, and tic disorders. The class of medications that have been used to treat these conditions includes Vesicular Monoamine Transporter-2 (VMAT2) inhibitors. In 2008, the FDA approved tetrabenazine as a treatment for chorea associated with Huntington's Disease. Optimization of the pharmacology of tetrabenazine has since led to the approval of two new VMAT2 inhibitors, deutetrabenazine and valbenazine. The objective of this review is to provide background on the role of VMAT in monoamine neurotransmission, the mechanism of VMAT2 inhibition on the treatment of hyperkinetic disorders (specifically tardive dyskinesia and chorea associated with Huntington's Disease), the pharmacology and pharmacokinetics of the commercially available VMAT2 inhibitors, and a summary of the clinical data to support application of these medications.

journal_name

Pharmacol Ther

authors

Koch J,Shi WX,Dashtipour K

doi

10.1016/j.pharmthera.2020.107580

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

107580

eissn

0163-7258

issn

1879-016X

pii

S0163-7258(20)30108-X

journal_volume

212

pub_type

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