Abstract：
:Hyperkinetic movement disorders comprise a variety of conditions characterized by involuntary movements, which include but are not limited to tardive dyskinesia, chorea associated with Huntington's Disease, and tic disorders. The class of medications that have been used to treat these conditions includes Vesicular Monoamine Transporter-2 (VMAT2) inhibitors. In 2008, the FDA approved tetrabenazine as a treatment for chorea associated with Huntington's Disease. Optimization of the pharmacology of tetrabenazine has since led to the approval of two new VMAT2 inhibitors, deutetrabenazine and valbenazine. The objective of this review is to provide background on the role of VMAT in monoamine neurotransmission, the mechanism of VMAT2 inhibition on the treatment of hyperkinetic disorders (specifically tardive dyskinesia and chorea associated with Huntington's Disease), the pharmacology and pharmacokinetics of the commercially available VMAT2 inhibitors, and a summary of the clinical data to support application of these medications.
journal_name
Pharmacol Therjournal_title
Pharmacology & therapeuticsauthors
Koch J,Shi WX,Dashtipour Kdoi
10.1016/j.pharmthera.2020.107580subject
Has Abstractpub_date
2020-08-01 00:00:00pages
107580eissn
0163-7258issn
1879-016Xpii
S0163-7258(20)30108-Xjournal_volume
212pub_type
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