Abstract:
:Poly (ADP-ribose) polymerase (PARP) inhibitors have transformed the therapeutic management of solid tumors, particularly ovarian cancer. Initially studied in BRCA deficient tumors, the Food and Drug Administration (FDA) indications have expanded to include other homologous recombination deficient tumors as well as biomarker-wildtype tumors. They have also gained momentum not only as a treatment strategy, but as a maintenance strategy as well. While PARP inhibitors were initially ev aluated in the recurrent setting, they have now moved to frontline therapy. This review will discuss the current FDA indications of the clinically available PARP inhibitors for treatment and maintenance therapies. We will then review the recently completed and ongoing clinical trials which may inform future clinical approvals.
journal_name
Pharmacol Therjournal_title
Pharmacology & therapeuticsauthors
Kurnit KC,Avila M,Hinchcliff EM,Coleman RL,Westin SNdoi
10.1016/j.pharmthera.2020.107588subject
Has Abstractpub_date
2020-09-01 00:00:00pages
107588eissn
0163-7258issn
1879-016Xpii
S0163-7258(20)30116-9journal_volume
213pub_type
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