Overcoming drug resistance to receptor tyrosine kinase inhibitors: Learning from lung cancer.


:There are various receptor tyrosine kinase (TK)-targeted drugs that are currently used in the treatment of patients with non-small cell lung cancer (NSCLC). Among them, the epidermal growth factor receptor (EGFR) TK inhibitors (TKIs) are the most extensively studied. Receptor TKIs including EGFR TKIs have shown dramatic therapeutic efficacies in malignant tumors, which harbor activating mutations in the EGFR gene. However, within 1 or 2years after treatment, patients harboring these mutations often develop resistance to TKI therapy. This review article is aimed at drawing attention to the fact that we must first understand how receptor TKI resistance is acquired to develop strategies for overcoming resistance to TKIs. Furthermore, an insight into the specific molecules or signaling pathways that mediate resistance is a key factor for understanding and overcoming acquired drug resistance. Finally, we present our views on the continuing battle against "drug resistance," and provide further guidelines and strategies on how to minimize the development of drug-resistant tumors.


Pharmacol Ther


Kuwano M,Sonoda K,Murakami Y,Watari K,Ono M




Has Abstract


2016-05-01 00:00:00












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    abstract::Unwanted cells are removed by physiological cell death processes that are highly conserved throughout the animal kingdom. Physiological cell death plays an important role in development, tissue homeostasis and defence against viral infection and mutation. This review describes the molecular components that implement t...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


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  • Cardiovascular side-effects of antipsychotic drugs: the role of the autonomic nervous system.

    abstract::Cardiovascular disease is the leading cause of death in people with severe mental disorders, and rates are proportionally greater than for other diseases such as cancer. Reports of sudden death in patients receiving antipsychotic treatment have raised concerns about the safety of antipsychotic drugs, leading to a numb...

    journal_title:Pharmacology & therapeutics

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  • Cardiac oxidative stress in diabetes: Mechanisms and therapeutic potential.

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    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


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  • A role for 5-HT in the action of antidepressant drugs.

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    journal_title:Pharmacology & therapeutics

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    journal_title:Pharmacology & therapeutics

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    pub_type: 杂志文章,评审


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  • Protein kinase inhibitors and antibiotic resistance.

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    journal_title:Pharmacology & therapeutics

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    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


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    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


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    更新日期:2009-08-01 00:00:00

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    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


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    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


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  • Epidemiology of poisoning.

    abstract::Despite difficulties in the interpretation of available data, certain general observations can be made on the epidemiology of poisioning. Childhood poisoning is usually accidental and tends to be associated with a low morbidity and mortality. In Western Europe and North America, it is most often due to household produ...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


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