KIT as a therapeutic target for non-oncological diseases.


:KIT is a receptor tyrosine kinase that after binding to its ligand stem cell factor activates signaling cascades linked to biological processes such as proliferation, differentiation, migration and cell survival. Based on studies performed on SCF and/or KIT mutant animals that presented anemia, sterility, and/or pigmentation disorders, KIT signaling was mainly considered to be involved in the regulation of hematopoiesis, gametogenesis, and melanogenesis. More recently, novel animal models and ameliorated cellular and molecular techniques have led to the discovery of a widen repertoire of tissue compartments and functions that are being modulated by KIT. This is the case for the lung, heart, nervous system, gastrointestinal tract, pancreas, kidney, liver, and bone. For this reason, the tyrosine kinase inhibitors that were originally developed for the treatment of hemato-oncological diseases are being currently investigated for the treatment of non-oncological disorders such as asthma, rheumatoid arthritis, and alzheimer's disease, among others. The beneficial effects of some of these tyrosine kinase inhibitors have been proven to depend on KIT inhibition. This review will focus on KIT expression and regulation in healthy and pathologic conditions other than cancer. Moreover, advances in the development of anti-KIT therapies, including tyrosine kinase inhibitors, and their application will be discussed.


Pharmacol Ther


Martinez-Anton A,Gras D,Bourdin A,Dubreuil P,Chanez P




Has Abstract


2019-05-01 00:00:00












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    abstract::In the past 4 years, RNA interference (RNAi) has become widely used as an experimental tool to analyse the function of mammalian genes, both in vitro and in vivo. By harnessing an evolutionary conserved endogenous biological pathway, first identified in plants and lower organisms, double-stranded RNA (dsRNA) reagents ...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


    authors: Leung RK,Whittaker PA

    更新日期:2005-08-01 00:00:00

  • Pharmacological control of gastric acid secretion for the treatment of acid-related peptic disease: past, present, and future.

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    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


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  • Advances in small molecules promoting neurotrophic function.

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    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


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    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


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    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


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    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


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  • Gold nanoparticles, radiations and the immune system: Current insights into the physical mechanisms and the biological interactions of this new alliance towards cancer therapy.

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    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


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    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


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    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


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    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


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    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


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    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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  • Challenges and achievements in the therapeutic modulation of aquaporin functionality.

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    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


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  • Delta opioid receptors in brain function and diseases.

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    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


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  • Nicotinic acetylcholine receptors: from basic science to therapeutics.

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    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


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  • Matrix reloaded: CCN, tenascin and SIBLING group of matricellular proteins in orchestrating cancer hallmark capabilities.

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    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


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    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


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    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


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    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


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    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


    authors: Hewett SJ,Bell SC,Hewett JA

    更新日期:2006-11-01 00:00:00

  • Novel therapeutics for type 2 diabetes: incretin hormone mimetics (glucagon-like peptide-1 receptor agonists) and dipeptidyl peptidase-4 inhibitors.

    abstract::Known treatments of type 2 diabetes mellitus have limitations such as weight gain, and hypoglycaemias. A new perspective is the use of incretin hormones and incretin enhancers. Incretins are defined as being responsible for the higher insulin release after an oral glucose load compared to an intravenous glucose load. ...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


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    更新日期:2009-10-01 00:00:00

  • Contribution of metabotropic GABA(B) receptors to neuronal network construction.

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    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


    authors: Gaiarsa JL,Kuczewski N,Porcher C

    更新日期:2011-11-01 00:00:00

  • Modulating microRNAs in cardiac surgery patients: Novel therapeutic opportunities?

    abstract::This review focuses on microRNAs (miRs) in cardiac surgery, where they are emerging as potential targets for therapeutic intervention as well as novel clinical biomarkers. Identification of the up/down-regulation of specific miRs in defined groups of cardiac surgery patients can lead to the development of novel strate...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


    authors: Biglino G,Caputo M,Rajakaruna C,Angelini G,van Rooij E,Emanueli C

    更新日期:2017-02-01 00:00:00

  • The sphingosine kinase-1/sphingosine-1-phosphate axis in cancer: Potential target for anticancer therapy.

    abstract::Sphingolipid metabolites, such as ceramide, sphingosine and sphingosine-1-phosphate (S1P), play many important roles in cellular activities. Ceramide and sphingosine inhibit cell proliferation and induce cell apoptosis while S1P has the opposite effect. Maintaining a metabolic balance of sphingolipids is essential for...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


    authors: Zheng X,Li W,Ren L,Liu J,Pang X,Chen X,Kang,Wang J,Du G

    更新日期:2019-03-01 00:00:00

  • Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing.

    abstract::Artemisinins are a unique class of antimalarial drugs with significant potential for drug repurposing for a wide range of diseases including cancer. Cancer is a leading cause of death globally and the majority of cancer related deaths occur in Low and Middle Income Countries (LMICs) where conventional treatment option...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


    authors: Augustin Y,Staines HM,Krishna S

    更新日期:2020-12-01 00:00:00

  • Cyclic nucleotide phosphodiesterases: New targets in the metabolic syndrome?

    abstract::Metabolic diseases have a tremendous impact on human morbidity and mortality. Numerous targets regulating adenosine monophosphate kinase (AMPK) have been identified for treating the metabolic syndrome (MetS), and many compounds are being used or developed to increase AMPK activity. In parallel, the cyclic nucleotide p...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


    authors: Lugnier C,Meyer A,Talha S,Geny B

    更新日期:2020-04-01 00:00:00