Abstract：
:This review takes a translational neuroscience perspective on the role of glutamate systems in human ethanol abuse and dependence. Ethanol is a simple molecule with profound effects on many chemical systems in the brain. Glutamate is the primary excitatory neurotransmitter in the brain. Glutamatergic systems are targets for the actions of ethanol via its antagonism of the N-methyl-D-aspartate (NMDA) subtype of the glutamate receptor and other mechanisms. The modulation of glutamatergic function by ethanol contributes to both euphoric and dysphoric consequences of ethanol intoxication. Adaptations within glutamatergic systems appear to contribute to ethanol tolerance and dependence and to both acute and protracted features of ethanol withdrawal. Perhaps because of the important glutamatergic mediation of the behavioral effects of ethanol, glutamatergic systems appear to contribute to the vulnerability to alcoholism, and novel glutamatergic agents may play a role in the treatment of ethanol abuse and dependence.
journal_name
Pharmacol Therjournal_title
Pharmacology & therapeuticsauthors
Krystal JH,Petrakis IL,Mason G,Trevisan L,D'Souza DCdoi
10.1016/s0163-7258(03)00054-8subject
Has Abstractpub_date
2003-07-01 00:00:00pages
79-94issue
1eissn
0163-7258issn
1879-016Xpii
S0163725803000548journal_volume
99pub_type
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