Intestinal toxicity of non-steroidal anti-inflammatory drugs.

Abstract:

:We review the adverse effect of non-steroidal anti-inflammatory drugs (NSAIDs) on the small and large intestine. NSAIDs cause small intestinal inflammation in 65% of patients receiving the drugs long-term. The clinical implications of NSAID-induced enteropathy are that patients bleed and lose protein from the inflammatory site, contributing to iron deficiency and hypoalbuminemia, respectively. Some patients develop intestinal strictures, which may require surgery, and the occasional one may develop discrete ulcers with perforations. There are a number of therapeutic options available to treat the enteropathy and the attendant complications, including antibiotics, sulphasalazine and misoprostol. The colon, by comparison, is only rarely affected by NSAIDs, but colitis is well recognized and NSAIDs may be an important factor in diverticular complications and the relapse of inflammatory bowel disease. There is an association between NSAID intake and appendicitis in the elderly.

journal_name

Pharmacol Ther

authors

Bjarnason I,Macpherson AJ

doi

10.1016/0163-7258(94)90008-6

subject

Has Abstract

pub_date

1994-04-01 00:00:00

pages

145-57

issue

1-2

eissn

0163-7258

issn

1879-016X

pii

0163-7258(94)90008-6

journal_volume

62

pub_type

杂志文章,评审
  • Importins and exportins as therapeutic targets in cancer.

    abstract::The nuclear transport proteins, importins and exportins (karyopherin-β proteins), may play an important role in cancer by transporting key mediators of oncogenesis across the nuclear membrane in cancer cells. During nucleocytoplasmic transport of tumor suppressor proteins and cell cycle regulators during the processin...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2016.03.020

    authors: Mahipal A,Malafa M

    更新日期:2016-08-01 00:00:00

  • Therapy of pulmonary hypertension in neonates and infants.

    abstract::Pulmonary hypertension (PH) in newborns and infants can present in its idiopathic form or complicate a long list of other diseases. Most of these conditions are either pulmonary or cardiovascular in origin. In the present review our current knowledge regarding pathophysiology, structural changes, diagnosis, and availa...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2007.03.006

    authors: Hoehn T

    更新日期:2007-06-01 00:00:00

  • The role of transporters in cellular heme and porphyrin homeostasis.

    abstract::Heme, a complex of iron and protoporphyrin IX (PPIX), senses and utilizes oxygen in nearly all living cells. It is an essential component of various hemoproteins, including those involved in oxygen transport and storage (hemoglobin, myoglobin), electron transfer, drug and steroid metabolism (cytochromes), and signal t...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2007.02.001

    authors: Krishnamurthy P,Xie T,Schuetz JD

    更新日期:2007-06-01 00:00:00

  • "Disease modifying nutricals" for multiple sclerosis.

    abstract::The association between vitamin D and multiple sclerosis has (re)-opened new interest in nutrition and natural compounds in the prevention and treatment of this neuroinflammatory disease. The dietary amount and type of fat, probiotics and biologicals, salmon proteoglycans, phytoestrogens and protease inhibitor of soy,...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2014.11.015

    authors: Schmitz K,Barthelmes J,Stolz L,Beyer S,Diehl O,Tegeder I

    更新日期:2015-04-01 00:00:00

  • Mesenchymal stem cells: From regeneration to cancer.

    abstract::Mesenchymal stem cells (MSCs) are multipotent tissue stem cells that differentiate into a number of mesodermal tissue types, including osteoblasts, adipocytes, chondrocytes and myofibroblasts. MSCs were originally identified in the bone marrow (BM) of humans and other mammals, but recent studies have shown that they a...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2019.04.005

    authors: Li P,Gong Z,Shultz LD,Ren G

    更新日期:2019-08-01 00:00:00

  • Therapeutic options for 5-lipoxygenase inhibitors.

    abstract::5-Lipoxygenase (5-LO) catalyzes the conversion of arachidonic acid (AA) into leukotriene (LT) A(4) and 5-hydroperoxyeicosatetraenoic acid. LTA(4) can then be converted into LTB(4) by LTA(4) hydrolase or into LTC(4) by LTC(4) synthase and the LTC(4) synthase isoenzymes MGST2 and MGST3. LTB(4) is a potent chemoattractan...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2006.05.009

    authors: Werz O,Steinhilber D

    更新日期:2006-12-01 00:00:00

  • Pluripotent stem cell differentiation into vascular cells: a novel technology with promises for vascular re(generation).

    abstract::Several types of stem and progenitor cells are currently under investigation for their potential to accomplish vascular regeneration. This review focuses on embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). We will discuss the technologies allowing for their derivation, culture expansion and main...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2010.10.004

    authors: Kane NM,Xiao Q,Baker AH,Luo Z,Xu Q,Emanueli C

    更新日期:2011-01-01 00:00:00

  • The pharmacological exploitation of cholesterol 7alpha-hydroxylase, the key enzyme in bile acid synthesis: from binding resins to chromatin remodelling to reduce plasma cholesterol.

    abstract::Mammals dispose of cholesterol mainly through 7alpha-hydroxylated bile acids, and the enzyme catalyzing the 7alpha-hydroxylation, cholesterol 7alpha-hydroxylase (CYP7A1), has a deep impact on cholesterol homeostasis. In this review, we present the study of regulation of CYP7A1 as a good exemplification of the extraord...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2007.08.003

    authors: Gilardi F,Mitro N,Godio C,Scotti E,Caruso D,Crestani M,De Fabiani E

    更新日期:2007-12-01 00:00:00

  • Cancer development and therapy resistance: spotlights on the dark side of the genome.

    abstract::Cancer research has been focusing so far on genetic alterations in protein-coding genes. However, mounting evidence underlines the importance of epigenetic and post-transcriptional events in cancer progression and therapy resistance. Moreover, recent genome-wide studies show that disease-causing mutations and chromoso...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2018.04.001

    authors: Leucci E

    更新日期:2018-09-01 00:00:00

  • Dopamine D2 autoreceptor interactome: Targeting the receptor complex as a strategy for treatment of substance use disorder.

    abstract::Dopamine D2 autoreceptors (D2ARs), located in somatodendritic and axon terminal compartments of dopamine (DA) neurons, function to provide a negative feedback regulatory control on DA neuron firing, DA synthesis, reuptake and release. Dysregulation of D2AR-mediated DA signaling is implicated in vulnerability to substa...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2020.107583

    authors: Chen R,Ferris MJ,Wang S

    更新日期:2020-09-01 00:00:00

  • Minor groove binders as anti-infective agents.

    abstract::Minor groove binders are small molecules that form strong complexes with the minor groove of DNA. There are several structural types of which distamycin and netropsin analogues, oligoamides built from heterocyclic and aromatic amino acids, and bis-amidines separated by aromatic and heterocyclic rings are of particular...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2013.03.002

    authors: Barrett MP,Gemmell CG,Suckling CJ

    更新日期:2013-07-01 00:00:00

  • Therapeutic targets in pulmonary arterial hypertension.

    abstract::Pulmonary arterial hypertension is a progressive, fatal disease. Current treatments including prostanoids, endothelin-1 (ET-1) antagonists, and phosphodiesterase (PDE) inhibitors, have sought to address the pulmonary vascular endothelial dysfunction and vasoconstriction associated with the condition. These treatments ...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2008.10.002

    authors: Rhodes CJ,Davidson A,Gibbs JS,Wharton J,Wilkins MR

    更新日期:2009-01-01 00:00:00

  • Molecular and clinical aspects of apoptosis.

    abstract::Unwanted cells are removed by physiological cell death processes that are highly conserved throughout the animal kingdom. Physiological cell death plays an important role in development, tissue homeostasis and defence against viral infection and mutation. This review describes the molecular components that implement t...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/s0163-7258(96)00098-8

    authors: Uren AG,Vaux DL

    更新日期:1996-01-01 00:00:00

  • Getting to the heart of asthma: can "beta blockers" be useful to treat asthma?

    abstract::beta(2)-adrenoceptor agonists are the mainstay for the acute symptomatic treatment of asthma and provide effective bronchoprotection to a wide range of bronchoconstrictor agents. However, over the past 4 decades there has been a continuing debate concerning whether regular chronic treatment with these drugs may be doi...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2007.04.009

    authors: Bond RA,Spina D,Parra S,Page CP

    更新日期:2007-09-01 00:00:00

  • Discovery of ATR kinase inhibitor berzosertib (VX-970, M6620): Clinical candidate for cancer therapy.

    abstract::Chemoresistance, radioresistance, and the challenge of achieving complete resection are major driving forces in the search for more robust and targeted anticancer therapies. Targeting the DNA damage response has recently attracted research interest, as these processes are enhanced in tumour cells. The major replicatio...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2020.107518

    authors: Gorecki L,Andrs M,Rezacova M,Korabecny J

    更新日期:2020-06-01 00:00:00

  • Histone deacetylase inhibitor (HDACI) mechanisms of action: emerging insights.

    abstract::Initially regarded as "epigenetic modifiers" acting predominantly through chromatin remodeling via histone acetylation, HDACIs, alternatively referred to as lysine deacetylase or simply deacetylase inhibitors, have since been recognized to exert multiple cytotoxic actions in cancer cells, often through acetylation of ...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2014.04.004

    authors: Bose P,Dai Y,Grant S

    更新日期:2014-09-01 00:00:00

  • TSPO in diverse CNS pathologies and psychiatric disease: A critical review and a way forward.

    abstract::The use of Translocator Protein 18 kDa (TSPO) as a clinical neuroimaging biomarker of brain injury and neuroinflammation has increased exponentially in the last decade. There has been a furious pace in the development of new radiotracers for TSPO positron emission tomography (PET) imaging and its use has now been exte...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2018.09.003

    authors: Guilarte TR

    更新日期:2019-02-01 00:00:00

  • Retinoid binding proteins and human skin.

    abstract::New techniques for the analysis of proteins with specific binding for natural retinoids in human plasma and skin extracts have been developed. Polyacrylamide gel electrophoresis (PAGE), followed by protein blotting with an antiserum specific to retinol-binding protein (RBP), the plasma carrier of retinol, showed that:...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/0163-7258(89)90073-9

    authors: Siegenthaler G,Saurat JH

    更新日期:1989-01-01 00:00:00

  • HMGB1 and repair: focus on the heart.

    abstract::High-mobility group box 1 (HMGB1) is one of the most abundant proteins in eukaryotes and the best characterized damage-associated molecular pattern (DAMP). The biological activities of HMGB1 depend on its subcellular location, context and post-translational modifications. Inside the nucleus, HMGB1 is engaged in many D...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2018.12.005

    authors: Pellegrini L,Foglio E,Pontemezzo E,Germani A,Russo MA,Limana F

    更新日期:2019-04-01 00:00:00

  • Cocaine use disorder: A look at metabotropic glutamate receptors and glutamate transporters.

    abstract::Glutamate transmission is an important mediator of the development of substance use disorders, particularly with regard to relapse. The present review summarizes the changes in glutamate levels in the reward system (the prefrontal cortex, nucleus accumbens, dorsal striatum, hippocampus, and ventral tegmental area) obs...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2020.107797

    authors: Niedzielska-Andres E,Pomierny-Chamioło L,Andres M,Walczak M,Knackstedt LA,Filip M,Przegaliński E

    更新日期:2021-01-09 00:00:00

  • Therapeutic applications of ribozymes.

    abstract::The demonstration that RNA can be cleaved by cis or trans ribozymes (catalytic RNAs, RNA enzymes) has potentially important therapeutic implications. Since their discovery in the 1980s, the biochemistry and conserved sequences of ribozymes have been well characterized. Ribozymes are effective modulators of gene expres...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/0163-7258(95)02008-x

    authors: Kijima H,Ishida H,Ohkawa T,Kashani-Sabet M,Scanlon KJ

    更新日期:1995-01-01 00:00:00

  • Cellular and molecular therapeutic modalities for arterial obstructive syndromes.

    abstract::Arterial obstructive syndromes result in heart disease, stroke and limb loss, disability, and mortality. Currently available therapeutics for patients with these conditions are inadequate or fail in a significant number of patients. The development of novel therapies for severe coronary arterial disease (CAD), periphe...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2005.08.005

    authors: Staudacher DL,Preis M,Lewis BS,Grossman PM,Flugelman MY

    更新日期:2006-01-01 00:00:00

  • In utero drug therapy.

    abstract::Drug therapy directed toward the fetus would be intended for either treating a fetal disorder or improving the capacity for later intrauterine or postnatal adaptation. Most reported trials involve single cases or small numbers of fetuses receiving the drug transplacentally after the first trimester, but before attaini...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/0163-7258(93)90051-e

    authors: Rayburn WF,Payne GG Jr

    更新日期:1993-01-01 00:00:00

  • Molecular events in adipocyte development.

    abstract::Adipocyte hyperplasia occurs by the proliferation and differentiation of adipocyte precursor cells or preadipocytes. Although the process of commitment to the adipocyte lineage is poorly understood, a great deal of information has accumulated about the processes and regulatory mechanisms involved in preadipocyte diffe...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/0163-7258(94)90018-3

    authors: Butterwith SC

    更新日期:1994-01-01 00:00:00

  • Renal dopamine receptors in health and hypertension.

    abstract::During the past decade, it has become evident that dopamine plays an important role in the regulation of renal function and blood pressure. Dopamine exerts its actions via a class of cell-surface receptors coupled to G-proteins that belong to the rhodopsin family. Dopamine receptors have been classified into two famil...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/s0163-7258(98)00027-8

    authors: Jose PA,Eisner GM,Felder RA

    更新日期:1998-11-01 00:00:00

  • Modulation of the tumor vasculature and oxygenation to improve therapy.

    abstract::The tumor microenvironment is increasingly recognized as a major factor influencing the success of therapeutic treatments and has become a key focus for cancer research. The progressive growth of a tumor results in an inability of normal tissue blood vessels to oxygenate and provide sufficient nutritional support to t...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2015.06.006

    authors: Siemann DW,Horsman MR

    更新日期:2015-09-01 00:00:00

  • VMAT2 inhibitors for the treatment of hyperkinetic movement disorders.

    abstract::Hyperkinetic movement disorders comprise a variety of conditions characterized by involuntary movements, which include but are not limited to tardive dyskinesia, chorea associated with Huntington's Disease, and tic disorders. The class of medications that have been used to treat these conditions includes Vesicular Mon...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2020.107580

    authors: Koch J,Shi WX,Dashtipour K

    更新日期:2020-08-01 00:00:00

  • Carnitine in metabolic disease: potential for pharmacological intervention.

    abstract::L-carnitine (LC) deficiency is commonly observed in chronic hemodialysis (HD) patients. As a result of this and other causes of secondary LC deficiencies, LC has been described as a "conditionally essential nutrient" or "conditional vitamin". Although a large number of clinical trials regarding the beneficial effects ...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.pharmthera.2008.08.008

    authors: Arduini A,Bonomini M,Savica V,Amato A,Zammit V

    更新日期:2008-11-01 00:00:00

  • Enhancement of 5-fluorouracil's anticancer activity by dipyridamole.

    abstract::Although the interaction between FUra and DP in HCT 116 cells is fairly complex, data from other investigators indicate that in cell lines in which inhibition of TS is growth limiting at relatively low concentrations of fluoropyrimidines, DP appears to augment the cytotoxicity of FUra and FdUrd by blocking the salvage...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/0163-7258(89)90084-3

    authors: Grem JL,Fischer PH

    更新日期:1989-01-01 00:00:00

  • Myotoxic components of snake venoms: their biochemical and biological activities.

    abstract::Necrosis of skeletal muscle is produced by two types of snake venom components: single chain peptides consisting of 42-44 amino acid residues and phospholipases A2 representing either single chain proteins or existing as complexes of several enzyme subunits or combined with other nonenzymatic proteins. Vacuolation, ly...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1016/0163-7258(90)90081-c

    authors: Mebs D,Ownby CL

    更新日期:1990-01-01 00:00:00