Intestinal toxicity of non-steroidal anti-inflammatory drugs.


:We review the adverse effect of non-steroidal anti-inflammatory drugs (NSAIDs) on the small and large intestine. NSAIDs cause small intestinal inflammation in 65% of patients receiving the drugs long-term. The clinical implications of NSAID-induced enteropathy are that patients bleed and lose protein from the inflammatory site, contributing to iron deficiency and hypoalbuminemia, respectively. Some patients develop intestinal strictures, which may require surgery, and the occasional one may develop discrete ulcers with perforations. There are a number of therapeutic options available to treat the enteropathy and the attendant complications, including antibiotics, sulphasalazine and misoprostol. The colon, by comparison, is only rarely affected by NSAIDs, but colitis is well recognized and NSAIDs may be an important factor in diverticular complications and the relapse of inflammatory bowel disease. There is an association between NSAID intake and appendicitis in the elderly.


Pharmacol Ther


Bjarnason I,Macpherson AJ




Has Abstract


1994-04-01 00:00:00














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    abstract::The nuclear transport proteins, importins and exportins (karyopherin-β proteins), may play an important role in cancer by transporting key mediators of oncogenesis across the nuclear membrane in cancer cells. During nucleocytoplasmic transport of tumor suppressor proteins and cell cycle regulators during the processin...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


    authors: Mahipal A,Malafa M

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    abstract::Pulmonary hypertension (PH) in newborns and infants can present in its idiopathic form or complicate a long list of other diseases. Most of these conditions are either pulmonary or cardiovascular in origin. In the present review our current knowledge regarding pathophysiology, structural changes, diagnosis, and availa...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


    authors: Hoehn T

    更新日期:2007-06-01 00:00:00

  • The role of transporters in cellular heme and porphyrin homeostasis.

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    journal_title:Pharmacology & therapeutics

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    authors: Krishnamurthy P,Xie T,Schuetz JD

    更新日期:2007-06-01 00:00:00

  • "Disease modifying nutricals" for multiple sclerosis.

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    journal_title:Pharmacology & therapeutics

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    authors: Schmitz K,Barthelmes J,Stolz L,Beyer S,Diehl O,Tegeder I

    更新日期:2015-04-01 00:00:00

  • Mesenchymal stem cells: From regeneration to cancer.

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    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


    authors: Li P,Gong Z,Shultz LD,Ren G

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    journal_title:Pharmacology & therapeutics

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    authors: Werz O,Steinhilber D

    更新日期:2006-12-01 00:00:00

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    journal_title:Pharmacology & therapeutics

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    authors: Kane NM,Xiao Q,Baker AH,Luo Z,Xu Q,Emanueli C

    更新日期:2011-01-01 00:00:00

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    authors: Gilardi F,Mitro N,Godio C,Scotti E,Caruso D,Crestani M,De Fabiani E

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    authors: Rhodes CJ,Davidson A,Gibbs JS,Wharton J,Wilkins MR

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    journal_title:Pharmacology & therapeutics

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    authors: Uren AG,Vaux DL

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    authors: Bond RA,Spina D,Parra S,Page CP

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    journal_title:Pharmacology & therapeutics

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    authors: Gorecki L,Andrs M,Rezacova M,Korabecny J

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    authors: Bose P,Dai Y,Grant S

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    journal_title:Pharmacology & therapeutics

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    journal_title:Pharmacology & therapeutics

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    authors: Siegenthaler G,Saurat JH

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    authors: Pellegrini L,Foglio E,Pontemezzo E,Germani A,Russo MA,Limana F

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    authors: Niedzielska-Andres E,Pomierny-Chamioło L,Andres M,Walczak M,Knackstedt LA,Filip M,Przegaliński E

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    authors: Kijima H,Ishida H,Ohkawa T,Kashani-Sabet M,Scanlon KJ

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    authors: Staudacher DL,Preis M,Lewis BS,Grossman PM,Flugelman MY

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    journal_title:Pharmacology & therapeutics

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    authors: Butterwith SC

    更新日期:1994-01-01 00:00:00

  • Renal dopamine receptors in health and hypertension.

    abstract::During the past decade, it has become evident that dopamine plays an important role in the regulation of renal function and blood pressure. Dopamine exerts its actions via a class of cell-surface receptors coupled to G-proteins that belong to the rhodopsin family. Dopamine receptors have been classified into two famil...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


    authors: Jose PA,Eisner GM,Felder RA

    更新日期:1998-11-01 00:00:00

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    journal_title:Pharmacology & therapeutics

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    authors: Siemann DW,Horsman MR

    更新日期:2015-09-01 00:00:00

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    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


    authors: Koch J,Shi WX,Dashtipour K

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    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


    authors: Arduini A,Bonomini M,Savica V,Amato A,Zammit V

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    journal_title:Pharmacology & therapeutics

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    authors: Grem JL,Fischer PH

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  • Myotoxic components of snake venoms: their biochemical and biological activities.

    abstract::Necrosis of skeletal muscle is produced by two types of snake venom components: single chain peptides consisting of 42-44 amino acid residues and phospholipases A2 representing either single chain proteins or existing as complexes of several enzyme subunits or combined with other nonenzymatic proteins. Vacuolation, ly...

    journal_title:Pharmacology & therapeutics

    pub_type: 杂志文章,评审


    authors: Mebs D,Ownby CL

    更新日期:1990-01-01 00:00:00