Abstract：
:Sepsis, a life threating syndrome characterized by organ failure after infection, is the most common cause of death in hospitalized patients. The treatment of sepsis is generally supportive in nature, involving the administration of intravenous fluids, vasoactive substances and oxygen plus antibiotics to eliminate the pathogen. No drugs have been approved specifically for the treatment of sepsis, and clinical trials of potential therapies have failed to reduce mortality - suggesting that new approaches are needed. Abnormalities in the immune response elicited by the pathogen, ranging from excessive inflammation to immunosuppression, contribute to disease pathogenesis. Although hundreds of immunomodulatory agents are potentially available, it remains unclear which patient benefits from which immune therapy at a given time point. Results indicate the importance of personalized therapy, specifically the need to identify the type of intervention required by each individual patient at a given point in the disease process. To address this issue will require using biomarkers to stratify patients based on their individual immune status. This article reviews recent and ongoing clinical investigations using immunostimulatory or immunosuppressive therapies against sepsis including non-pharmacological and novel preclinical approaches.
journal_name
Pharmacol Therjournal_title
Pharmacology & therapeuticsauthors
Steinhagen F,Schmidt SV,Schewe JC,Peukert K,Klinman DM,Bode Cdoi
10.1016/j.pharmthera.2020.107476subject
Has Abstractpub_date
2020-04-01 00:00:00pages
107476eissn
0163-7258issn
1879-016Xpii
S0163-7258(20)30004-8journal_volume
208pub_type
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