Abstract：
:Atrial fibrillation (AF) is a growing clinical problem associated with increased morbidity and mortality. Development of safe and effective pharmacological treatments for AF is one of the greatest unmet medical needs facing our society. In spite of significant progress in non-pharmacological AF treatments (largely due to the use of catheter ablation techniques), anti-arrhythmic agents (AADs) remain first line therapy for rhythm control management of AF for most AF patients. When considering efficacy, safety and tolerability, currently available AADs for rhythm control of AF are less than optimal. Ion channel inhibition remains the principal strategy for termination of AF and prevention of its recurrence. Practical clinical experience indicates that multi-ion channel blockers are generally more optimal for rhythm control of AF compared to ion channel-selective blockers. Recent studies suggest that atrial-selective sodium channel block can lead to safe and effective suppression of AF and that concurrent inhibition of potassium ion channels may potentiate this effect. An important limitation of the ion channel block approach for AF treatment is that non-electrical factors (largely structural remodeling) may importantly determine the generation of AF, so that "upstream therapy", aimed at preventing or reversing structural remodeling, may be required for effective rhythm control management. This review focuses on novel pharmacological targets for the rhythm control management of AF.
journal_name
Pharmacol Therjournal_title
Pharmacology & therapeuticsauthors
Burashnikov A,Antzelevitch Cdoi
10.1016/j.pharmthera.2011.08.002subject
Has Abstractpub_date
2011-12-01 00:00:00pages
300-13issue
3eissn
0163-7258issn
1879-016Xpii
S0163-7258(11)00166-5journal_volume
132pub_type
杂志文章,评审abstract：:Substantial progress in the identification of genes encoding for a large number of proteins responsible for various aspects of neurotransmitter release, postsynaptic detection and downstream signaling, has advanced our understanding of the mechanisms by which neurons communicate and interact. Nicotinic acetylcholine r...
journal_title：Pharmacology & therapeutics
pub_type： 杂志文章,评审
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更新日期：2013-01-01 00:00:00
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journal_title：Pharmacology & therapeutics
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journal_title：Pharmacology & therapeutics
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更新日期：2011-11-01 00:00:00
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journal_title：Pharmacology & therapeutics
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journal_title：Pharmacology & therapeutics
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journal_title：Pharmacology & therapeutics
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journal_title：Pharmacology & therapeutics
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journal_title：Pharmacology & therapeutics
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journal_title：Pharmacology & therapeutics
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journal_title：Pharmacology & therapeutics
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journal_title：Pharmacology & therapeutics
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更新日期：1991-01-01 00:00:00
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journal_title：Pharmacology & therapeutics
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更新日期：1999-12-01 00:00:00
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journal_title：Pharmacology & therapeutics
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更新日期：2009-07-01 00:00:00
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journal_title：Pharmacology & therapeutics
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doi：10.1016/0163-7258(94)90046-9
更新日期：1994-08-01 00:00:00
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journal_title：Pharmacology & therapeutics
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更新日期：2006-12-01 00:00:00
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journal_title：Pharmacology & therapeutics
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journal_title：Pharmacology & therapeutics
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journal_title：Pharmacology & therapeutics
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journal_title：Pharmacology & therapeutics
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journal_title：Pharmacology & therapeutics
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journal_title：Pharmacology & therapeutics
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更新日期：2010-03-01 00:00:00
abstract：:Phosphorothioate (PS) oligodeoxynucleotides are relatively nuclease resistant, water soluble analogs of phosphodiester (PO) oligodeoxynucleotides. These molecules are chiral but still hybridize well to their RNA targets. While considered for use as in vivo anti-sense inhibitors of gene expression, their biology, espec...
journal_title：Pharmacology & therapeutics
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更新日期：1991-12-01 00:00:00
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journal_title：Pharmacology & therapeutics
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更新日期：2015-02-01 00:00:00
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journal_title：Pharmacology & therapeutics
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更新日期：2005-08-01 00:00:00
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journal_title：Pharmacology & therapeutics
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更新日期：2015-12-01 00:00:00
abstract：:The ever-growing global burden of congestive heart failure (CHF) and type 2 diabetes mellitus (T2DM) as well as their co-existence necessitate that anti-diabetic pharmacotherapy will modulate the cardiovascular risk inherent to T2DM while complying with the accompanying restrictions imposed by CHF. The thiazolidinedio...
journal_title：Pharmacology & therapeutics
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更新日期：2016-12-01 00:00:00
abstract：:Mechanistic insights of cancer immunology have led to the development of immune checkpoint blockade therapy (ICBT), which has elicited a remarkable clinical response in some cancer patients. Increasing evidence suggests that activation of oncogenic pathways, such as RAS/RAF/MAPK and PI3K signaling, impairs the antitum...
journal_title：Pharmacology & therapeutics
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更新日期：2018-01-01 00:00:00
abstract：:RANKL is a key molecule that bridges the bone and immune systems. RANKL stimulation activates a signaling pathway downstream of RANK, thereby determining the extent of bone resorption by inducing osteoclast maturation. The signaling pathway also regulates the development of different lymphoid organs, including the thy...
journal_title：Pharmacology & therapeutics
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doi：10.1016/j.pharmthera.2020.107682
更新日期：2021-02-01 00:00:00
