Abstract：
:Pulmonary arterial hypertension is a progressive, fatal disease. Current treatments including prostanoids, endothelin-1 (ET-1) antagonists, and phosphodiesterase (PDE) inhibitors, have sought to address the pulmonary vascular endothelial dysfunction and vasoconstriction associated with the condition. These treatments may slow the progression of the disease but do not afford a cure. Future treatments must target more directly the structural vascular changes that impair blood flow through the pulmonary circulation. Several novel therapeutic targets have been proposed and are under active investigation, including soluble guanylyl cyclase, phosphodiesterases, tetrahydrobiopterin, 5-HT2B receptors, vasoactive intestinal peptide, receptor tyrosine kinases, adrenomedullin, Rho kinase, elastases, endogenous steroids, endothelial progenitor cells, immune cells, bone morphogenetic protein and its receptors, potassium channels, metabolic pathways, and nuclear factor of activated T cells. Tyrosine kinase inhibitors, statins, 5-HT2B receptor antagonists, EPCs and soluble guanylyl cyclase activators are among the most advanced, having produced encouraging results in animal models, and human trials are underway. This review summarises the current research in this area and speculates on their likely success.
journal_name
Pharmacol Therjournal_title
Pharmacology & therapeuticsauthors
Rhodes CJ,Davidson A,Gibbs JS,Wharton J,Wilkins MRdoi
10.1016/j.pharmthera.2008.10.002subject
Has Abstractpub_date
2009-01-01 00:00:00pages
69-88issue
1eissn
0163-7258issn
1879-016Xpii
S0163-7258(08)00193-9journal_volume
121pub_type
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journal_title：Pharmacology & therapeutics
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