Abstract:
:The thyroid hormone (TH; 3,3',5,5'-tetra-iodothyronine and 3,3',5'-triiodothyronine) regulates growth, development, and critical metabolic functions. Thyroid diseases are among the most prevalent group of metabolic disorders in the Western world. TH exerts effects through complex biological pathways, which offer a wealth of opportunities to pharmacologically intervene in TH signalling at numerous steps. These include biosynthesis, cell-specific uptake or export (involving L-type amino acid transporter, organic anion transporter, organic cation transporter, or multidrug resistance transporter), as well as nuclear targeting and actions (the latter including TH receptor binding and histone acetylation/deacetylation). Such processes represent potentially important pharmacological targets for the design of novel or improved therapies for TH disorders, obesity, and cardiovascular diseases.
journal_name
Pharmacol Therjournal_title
Pharmacology & therapeuticsauthors
Shi YB,Ritchie JW,Taylor PMdoi
10.1016/s0163-7258(02)00219-xsubject
Has Abstractpub_date
2002-06-01 00:00:00pages
235-51issue
3eissn
0163-7258issn
1879-016Xpii
S016372580200219Xjournal_volume
94pub_type
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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