Abstract：
:A number of inherited or drug-induced metabolic disorders involving dysfunctions in purines and pyrimidines are strongly associated with neurological dysfunction, e.g., Lesch Nyhan syndrome. Such disorders have been studied extensively using biochemical and molecular techniques in order to examine how such defects occur, sometimes using in vitro models based upon cultured neuroblastoma cell lines. However, these metabolic dysfunctions may manifest their effects in other ways, such as impaired synaptic transmission and gross abnormalities in neuronal growth and differentiation. This review outlines the latter novel facet of purine research. It is proposed that by employing cell imaging techniques and cultured neuroblastoma cell lines, believed to model the nervous system, significant insights into how inherited disorders of purine metabolism affect neuronal development can be obtained. This review provides an example of the application of these techniques to understand the etiology of Lesch Nyhan syndrome, and encourages further study of the role of purines and pyrimidines in the development of the nervous system.
journal_name
Pharmacol Therjournal_title
Pharmacology & therapeuticsauthors
Connolly GPdoi
10.1016/s0163-7258(01)00141-3subject
Has Abstractpub_date
2001-05-01 00:00:00pages
267-81issue
2-3eissn
0163-7258issn
1879-016Xpii
S0163-7258(01)00141-3journal_volume
90pub_type
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