Abstract:
:There is substantial molecular evidence for the involvement of beta1 integrin in tissue organisation and remodelling, which confers a key role in cell growth, differentiation, migration, and survival. This role has been, in part, highlighted using the transgenic approach which does little to define the more subtle functions such as those controlled by avidity regulation. Upon activation integrins in general, including beta1 integrin, are known to exhibit global structural rearrangement and exposure of ligand binding sites. Recent evidence has revealed a role of beta1 integrin modulation in tissue repair and regeneration. The anomalies and phenomena describing the roles of beta1 integrin in tissue remodelling are reviewed, as well as the tools which have been used to define the functions of beta1 integrin and its impact on our understanding of the diverse roles of beta1 integrin in remodelling. This eclectic mix of phenomena is conceptualised to form a unified hypothesis of a novel understanding of both tissue injury and repair.
journal_name
Pharmacol Therjournal_title
Pharmacology & therapeuticsauthors
Al-Jamal R,Harrison DJdoi
10.1016/j.pharmthera.2008.07.002subject
Has Abstractpub_date
2008-11-01 00:00:00pages
81-101issue
2eissn
0163-7258issn
1879-016Xpii
S0163-7258(08)00122-8journal_volume
120pub_type
杂志文章,评审abstract::Pharmacological agents, such as histamine H(2) receptor antagonists and acid pump inhibitors, are now the most frequently used treatment for such acid-related diseases as gastroduodenal ulcers and reflux esophagitis. Based on increased understanding of the precise mechanisms of gastric acid secretion at the level of r...
journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
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abstract::Asthma is a chronic disorder characterized by persistent inflammation of the airways with mucosal infiltration of eosinophils, T lymphocytes, and mast cells, and release of proinflammatory cytokines and lipid mediators. The natural resolution of airway inflammation is now recognized as an active host response, with hi...
journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
doi:10.1016/j.pharmthera.2014.01.001
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journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
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journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
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journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
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journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
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journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
doi:10.1016/j.pharmthera.2006.12.003
更新日期:2007-03-01 00:00:00
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journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
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journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
doi:10.1016/j.pharmthera.2008.02.002
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journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
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journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
doi:10.1016/0163-7258(91)90077-y
更新日期:1991-01-01 00:00:00
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journal_title:Pharmacology & therapeutics
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更新日期:2000-03-01 00:00:00
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journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
doi:10.1016/j.pharmthera.2010.08.010
更新日期:2010-12-01 00:00:00
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journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
doi:10.1016/j.pharmthera.2014.04.004
更新日期:2014-09-01 00:00:00
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journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
doi:10.1016/j.pharmthera.2015.06.006
更新日期:2015-09-01 00:00:00
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journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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journal_title:Pharmacology & therapeutics
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abstract::Angiotensin II (Ang II) is the main effector hormone of the renin-angiotensin system (RAS). The pathogenesis of many cardiovascular diseases, including heart failure and hypertension, appear to be related to Ang II production. The generation of Ang II involves angiotensin-converting enzyme (ACE) in circulating and tis...
journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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doi:10.1016/j.pharmthera.2006.04.008
更新日期:2006-11-01 00:00:00
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journal_title:Pharmacology & therapeutics
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doi:10.1016/j.pharmthera.2019.03.006
更新日期:2019-07-01 00:00:00
abstract::Glucose-6-phospate dehydrogenase (G6PD) deficiency is estimated to affect more than 400 million people world-wide. This X-linked genetic deficiency puts stress on red blood cells (RBC), which may be further augmented under certain pathophysiological conditions and drug treatments. These conditions can cause hemolytic ...
journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
doi:10.1016/j.pharmthera.2020.107788
更新日期:2020-12-14 00:00:00
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journal_title:Pharmacology & therapeutics
pub_type: 杂志文章
doi:10.1016/j.pharmthera.2008.05.006
更新日期:2008-08-01 00:00:00
abstract::The receptor tyrosine kinase MERTK is aberrantly expressed in numerous human malignancies, and is a novel target in cancer therapeutics. Physiologic roles of MERTK include regulation of tissue homeostasis and repair, innate immune control, and platelet aggregation. However, aberrant expression in a wide range of liqui...
journal_title:Pharmacology & therapeutics
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abstract::In the past 4 years, RNA interference (RNAi) has become widely used as an experimental tool to analyse the function of mammalian genes, both in vitro and in vivo. By harnessing an evolutionary conserved endogenous biological pathway, first identified in plants and lower organisms, double-stranded RNA (dsRNA) reagents ...
journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
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更新日期:2005-08-01 00:00:00
abstract::A variety of drug transporters expressed in the body control the fate of drugs by affecting absorption, distribution, and elimination processes. In the small intestine, transporters mediate the influx and efflux of endogenous or exogenous substances. In clinical pharmacotherapy, ATP-dependent efflux transporters (ATP-...
journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
doi:10.1016/j.pharmthera.2005.06.005
更新日期:2006-01-01 00:00:00
abstract::The vascular endothelium not only is a single monolayer of cells between the vessel lumen and the intimal wall, but also plays an important role by controlling vascular function and structure mainly via the production of nitric oxide (NO). The so called "cardiovascular risk factors" are associated with endothelial dys...
journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
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