Abstract：
:The science of Tourette Syndrome (TS) is advancing at multiple levels of analysis and will be enhanced through the use of animal models. Particular challenges in the development of TS animal models reflect complex features of this disorder, including its waxing and waning course and its "invisible" sensory and psychic symptoms. Animal models can achieve face, predictive, or construct validity based on their particular features. Predictive validity, of most direct relevance to drug development for TS, is achieved to some degree by a several animal models, although the reliance of most of these models on measures of motor suppression may ultimately limit their utility. Other models achieve construct validity with proposed pathophysiological mechanisms related to the immune and neural circuit etiologies of TS. One model-deficient sensorimotor gating of the startle reflex-is discussed in terms of its present and future applications towards advancing our understanding of the pathophysiology and treatment of TS. In addition to models that will advance the pharmacotherapy of TS, other animal models may enhance the utility of nonpharmacologic TS treatments, ranging from behavior therapy to deep brain stimulation (DBS).
journal_name
Pharmacol Therjournal_title
Pharmacology & therapeuticsauthors
Swerdlow NR,Sutherland ANdoi
10.1016/j.pharmthera.2005.05.003subject
Has Abstractpub_date
2005-12-01 00:00:00pages
281-93issue
3eissn
0163-7258issn
1879-016Xpii
S0163-7258(05)00100-2journal_volume
108pub_type
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journal_title：Pharmacology & therapeutics
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更新日期：2007-12-01 00:00:00
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更新日期：2002-04-01 00:00:00
