Abstract:
:Asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness (AHR), tissue remodeling, and airflow obstruction. The pathogenesis of asthma is only partly understood, and there is an urgent need for improved therapeutic strategies for this disease. Microarray technology has considerable promise as a tool for discovery of novel asthma therapeutic targets, although the field is still in its infancy. A number of studies have described expression profiles derived from human asthmatic lung tissue, mouse airway tissue, or from key cell types associated with asthma, but to date relatively few studies have exploited these findings to discover new pathways involved in the pathogenesis of asthma. Among the genes to have been identified by array studies and validated by further studies are monokine induced by interferon (IFN)-gamma, fatty acid binding proteins (FABP), and complement factor 5 (C5). Here we provide examples of microarray approaches to the discovery of new molecules associated with asthma. We anticipate that these types of analyses will provide considerable insight into asthma pathogenesis and will provide a wealth of new molecules for downstream analyses such as gene deficient mouse studies, or monoclonal antibody production.
journal_name
Pharmacol Therjournal_title
Pharmacology & therapeuticsauthors
Rolph MS,Sisavanh M,Liu SM,Mackay CRdoi
10.1016/j.pharmthera.2005.08.009subject
Has Abstractpub_date
2006-01-01 00:00:00pages
284-94issue
1-2eissn
0163-7258issn
1879-016Xpii
S0163-7258(05)00184-1journal_volume
109pub_type
杂志文章,评审abstract::Favipiravir has been developed as an anti-influenza drug and licensed as an anti-influenza drug in Japan. Additionally, favipiravir is being stockpiled for 2 million people as a countermeasure for novel influenza strains. This drug functions as a chain terminator at the site of incorporation of the viral RNA and reduc...
journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
pub_type: 历史文章,杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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