Abstract:
:Numerous pro-inflammatory cytokines have been implicated in the pathogenesis of several cardiovascular diseases. Interleukin (IL)-33 is a new member of the IL-1 family of cytokines that promotes Th2 type immune responses by signaling through the ST2L and IL-1RAcP dimeric receptor complex. Furthermore, the biological effects of IL-33 are limited by a soluble decoy form of ST2 (sST2). Recent studies indicate a protective role for IL-33 and ST2L in atherosclerosis, obesity and cardiac remodeling. The present review summarizes currently available data showing the role for IL-33 and its receptor ST2L within cardiovascular disease, and the potential use of sST2 as a predictive cardiovascular biomarker.
journal_name
Pharmacol Therjournal_title
Pharmacology & therapeuticsauthors
Miller AM,Liew FYdoi
10.1016/j.pharmthera.2011.02.005subject
Has Abstractpub_date
2011-08-01 00:00:00pages
179-86issue
2eissn
0163-7258issn
1879-016Xpii
S0163-7258(11)00053-2journal_volume
131pub_type
杂志文章,评审abstract::Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) was initially identified as the major receptor for oxidized LDL (OxLDL) in endothelial cells. Its inducible expression in macrophages and smooth muscle cell was also observed. LOX-1 is a Type II membrane protein with a typical C-type lectin structur...
journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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doi:10.1016/j.pharmthera.2008.03.006
更新日期:2008-08-01 00:00:00
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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更新日期:2004-01-01 00:00:00
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journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
doi:10.1016/s0163-7258(02)00252-8
更新日期:2002-08-01 00:00:00
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journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
doi:10.1016/j.pharmthera.2015.10.003
更新日期:2015-12-01 00:00:00
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journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
doi:10.1016/j.pharmthera.2015.06.009
更新日期:2015-10-01 00:00:00
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journal_title:Pharmacology & therapeutics
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doi:10.1016/j.pharmthera.2017.05.007
更新日期:2017-11-01 00:00:00
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journal_title:Pharmacology & therapeutics
pub_type: 杂志文章,评审
doi:10.1016/j.pharmthera.2011.04.002
更新日期:2011-07-01 00:00:00
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journal_title:Pharmacology & therapeutics
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doi:10.1016/s0163-7258(03)00015-9
更新日期:2003-04-01 00:00:00
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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更新日期:1997-08-01 00:00:00
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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journal_title:Pharmacology & therapeutics
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