Abstract：
:Nucleoside monophosphate kinases catalyze the reversible phosphotransferase reaction between nucleoside triphosphates and monophosphates, i.e., monophosphates are converted to their corresponding diphosphate form. These enzymes play an important role in the synthesis of nucleotides that are required for a variety of cellular metabolic processes, as well as for RNA and DNA synthesis. Human tissues contain a thymidylate kinase, a uridylate-cytidylate kinase, five isozymes of adenylate kinase, and several guanylate kinases. Nucleoside monophosphate kinases are also required for the pharmacological activation of therapeutic nucleoside and nucleotide analogs. This overview is focused on the substrate specificity, tissue distribution, and subcellular location of the mammalian monophosphate kinases and their role in the activation of nucleoside and nucleotide analogs.
journal_name
Pharmacol Therjournal_title
Pharmacology & therapeuticsauthors
Van Rompay AR,Johansson M,Karlsson Adoi
10.1016/s0163-7258(00)00048-6subject
Has Abstractpub_date
2000-08-01 00:00:00pages
189-98issue
2-3eissn
0163-7258issn
1879-016Xpii
S0163725800000486journal_volume
87pub_type
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