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Celiac disease with mild to moderate histologic changes is a common cause of chronic diarrhea in Indian children.

Abstract：

OBJECTIVES:In developed countries, small bowel histology in coeliac disease is a spectrum, ranging from normal with increased intraepithelial lymphocytes to the classic flat mucosa. In developing countries, mild to moderate enteropathies in children with chronic diarrhea and growth failure are assumed to be caused by tropical sprue, persistent infections, or malnutrition with bacterial overgrowth. We report the prevalence and histology of coeliac disease in children with chronic diarrhea at a tertiary referral hospital in North India. METHODS:Two hundred fifty-nine children with symptoms indicating coeliac disease attended the All India Institute of Medical Sciences. Histology was graded after a modified Marsh classification. Serum immunoglobulin A anti-endomysial antibodies (AEA) were assayed using indirect immunofluorescence. Subjects with abnormal histology and positive AEA were put on a gluten free diet (GFD). Coeliac disease was diagnosed on small intestinal biopsy changes and a clinical response to a GFD. RESULTS:Severe enteropathies were present in 63 (24%) subjects, and 58 (92%) responded to a GFD. Sixty-six (25%) had moderate histologic changes, 61 responding to a GFD. AEA was positive in 56 of 63 patients with severe and 65 of 66 with moderate enteropathies. Fifty-seven children had mild enteropathies, and 19 of 20 with positive AEA responded clinically to a GFD. CONCLUSIONS:Coeliac disease is more common than previously believed. It presents a variable histology, and diagnoses may be missed or delayed if based only on severe enteropathies. Serology is a useful adjunct to diagnosis, and diagnostic criteria need to be developed appropriately for coeliac disease in developing countries despite limited facilities.

journal_name

J Pediatr Gastroenterol Nutr

journal_title

Journal of pediatric gastroenterology and nutrition

authors

Bhatnagar S,Gupta SD,Mathur M,Phillips AD,Kumar R,Knutton S,Unsworth DJ,Lock RJ,Natchu UC,Mukhopadhyaya S,Saini S,Bhan MK

doi

10.1097/01.mpg.0000172261.24115.29

subject

Has Abstract

pub_date

2005-08-01 00:00:00

pages

204-9

issue

eissn

0277-2116

issn

1536-4801

pii

00005176-200508000-00009

journal_volume

pub_type

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Celiac disease with mild to moderate histologic changes is a common cause of chronic diarrhea in Indian children.