Obesity Does Not Affect Early Outcomes in Children With Newly Diagnosed Crohn Disease.

Abstract:

:The impact of obesity on pediatric Crohn disease (CD) remains poorly characterized. We aimed to evaluate disease-related outcomes in overweight and obese children with CD, compared to normal-weight children. We conducted a retrospective cohort study of children with newly diagnosed CD enrolled in the ImproveCareNow Network. Patients were stratified into normal weight, overweight, and obese groups using standardized weight percentiles. A total of 898 children were included, with 87 children (10%) being overweight and 43 children (5%) being obese; baseline characteristics were similar between groups. There was no significant difference in number of visits in remission during 1 year between normal weight, overweight, and obese children. At 1-year follow-up, nutritional status, growth status, or medication use also did not differ between groups. Hence, obesity does not appear to adversely affect CD outcomes in children with newly diagnosed CD in the first year after diagnosis.

authors

Jain A,Bricker J,Kappelman MD,Dotson JL

doi

10.1097/MPG.0000000000002066

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

622-625

issue

5

eissn

0277-2116

issn

1536-4801

journal_volume

67

pub_type

杂志文章
  • Antiendomysial antibody detection in biopsy culture allows avoidance of gluten challenge in celiac children.

    abstract:OBJECTIVE:Antiendomysial antibody (EMA) production has been induced in vitro by the small bowel mucosa of celiac disease (CD) patients in clinical remission cultured in the presence of gliadin peptides. The aim of the present study was to use this in vitro system to determine whether it could be used to predict the cli...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00005176-200502000-00015

    authors: Bonamico M,Sabbatella L,Di Tola M,Vetrano S,Ferri M,Nenna R,Mariani P,Picarelli A

    更新日期:2005-02-01 00:00:00

  • Increasing incidence of paediatric inflammatory bowel disease in northern Stockholm County, 2002-2007.

    abstract:OBJECTIVES:A sharp increase in paediatric (younger than 16 years) inflammatory bowel disease (IBD) incidence was observed in northern Stockholm County, Sweden, in 1990-2001. The increasing incidence was primarily explained by a rising incidence of Crohn disease (CD). Here, we present an update on the trends in incidenc...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e31828f21b4

    authors: Malmborg P,Grahnquist L,Lindholm J,Montgomery S,Hildebrand H

    更新日期:2013-07-01 00:00:00

  • Thiamine, riboflavin, pyridoxine, and vitamin C status in premature infants receiving parenteral and enteral nutrition.

    abstract:BACKGROUND:There is a paucity of data about water soluble vitamin status in low birthweight infants. Therefore, the authors' objective was to assess current feeding protocols. METHODS:The authors measured serum concentrations for riboflavin, pyridoxine, and vitamin C and functional assays for thiamine and riboflavin l...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-200107000-00011

    authors: Friel JK,Bessie JC,Belkhode SL,Edgecombe C,Steele-Rodway M,Downton G,Kwa PG,Aziz K

    更新日期:2001-07-01 00:00:00

  • Cow's-milk allergy is a risk factor for the development of FGIDs in children.

    abstract:OBJECTIVES:Functional gastrointestinal disorders (FGIDs) are common in children. Their pathogenesis remains unknown and is most likely multifactorial. We hypothesized that noninfectious causes of inflammation affecting the gastrointestinal (GI) tract early in life, such as cow's-milk allergy (CMA), can predispose to th...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e3181e85b55

    authors: Saps M,Lu P,Bonilla S

    更新日期:2011-02-01 00:00:00

  • Esophageal subepithelial fibrosis and hyalinization are features of eosinophilic esophagitis.

    abstract:BACKGROUND AND OBJECTIVE:Eosinophilic esophagitis (EE) is characterized by marked esophageal mucosal eosinophilia on histological examination. Although the clinical and histological features of EE are increasingly recognized, the overlap of clinical symptoms and histological findings with gastroesophageal reflux diseas...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e3181ef37a1

    authors: Li-Kim-Moy JP,Tobias V,Day AS,Leach S,Lemberg DA

    更新日期:2011-02-01 00:00:00

  • Probiotics and functional gastrointestinal disorders in children.

    abstract::Chronic constipation is one of the most frequent complaints in childhood. Although there is evidence that gastrointestinal flora is important in gut motility, there is little evidence that gut flora is abnormal in constipation. Lactobacilli and bifidobacteria increase stool frequency and decrease consistency in normal...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:10.1097/MPG.0b013e3181a1603a

    authors: Vandenplas Y,Benninga M

    更新日期:2009-04-01 00:00:00

  • Growth and change in blood haemoglobin concentration among underweight Malawian infants receiving fortified spreads for 12 weeks: a preliminary trial.

    abstract:OBJECTIVE:Fortified spreads (FSs) have proven effective in the rehabilitation of severely malnourished children. We examined acceptability, growth and change in blood haemoglobin (Hb) concentration among moderately underweight ambulatory infants given FS. METHODS:This was a randomised, controlled, parallel-group, inve...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/01.mpg.0000235981.26700.d3

    authors: Kuusipalo H,Maleta K,Briend A,Manary M,Ashorn P

    更新日期:2006-10-01 00:00:00

  • Faecal bile acid and dietary residue excretion in cystic fibrosis: age group variations.

    abstract:BACKGROUND:Earlier studies report the excessive faecal excretions of bile acids and dietary residues in cystic fibrosis (CF). However, few of these investigated large groups of patients using modern pancreatin preparations and little data exists reporting carbohydrate excretion. We therefore aimed to characterise the g...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199809000-00005

    authors: Walters MP,Littlewood JM

    更新日期:1998-09-01 00:00:00

  • Electrogastrography, Near-infrared Spectroscopy, and Acoustics to Measure Gastrointestinal Development in Preterm Babies.

    abstract:OBJECTIVES:The aim of the study was to obtain objective measures indicative of gastrointestinal maturity using 3 noninvasive technologies. METHODS:Electrogastrography (EGG), abdominal near-infrared spectroscopy (NIRS), and bowel sound/acoustics (AC) monitoring were used simultaneously to obtain physiologic measures of...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章

    doi:10.1097/MPG.0000000000001867

    authors: Ortigoza EB,Cagle J,Chien JH,Oh S,Brown LS,Neu J

    更新日期:2018-06-01 00:00:00

  • Treatment of recurrent abdominal pain: components analysis of four treatment protocols.

    abstract:BACKGROUND:Recurrent abdominal pain (RAP) affects up to 34% of the world's population of children. Medical management has been limited, but behavioral strategies have been shown to be effective. In this study several components of published treatment protocols were adapted and/or improved and then compared using a pret...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00005176-200007000-00011

    authors: Humphreys PA,Gevirtz RN

    更新日期:2000-07-01 00:00:00

  • Accuracy of a Genetic Test for the Diagnosis of Hypolactasia in Chilean Children: Comparison With the Breath Test.

    abstract:BACKGROUND:Lactase nonpersistence (LNP) in humans is a genetically determined trait. This age-dependent decrease of lactase expression is most frequently caused by single nucleotide polymorphisms in the regulatory region of the lactase (LCT) gene. The homozygous LCT-13,910C/C genotype (rs 4988235) predominates in Cauca...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001208

    authors: Alliende F,Vial C,Espinoza K,Schnettle D,Romero V,Miquel I,Arancibia ME,Rios G,Rodriguez L,Quesada S,Lucero Y,Repetto GM

    更新日期:2016-07-01 00:00:00

  • Effects of zinc exposure on zinc transporter expression in human intestinal cells of varying maturity.

    abstract:OBJECTIVES:Zinc (Zn) homeostasis in adults is achieved principally through a balance between intestinal absorption and excretion involving adaptive mechanisms programmed by levels of dietary Zn. Zn absorption in infants is not as tightly regulated as that in adults, which may induce potential toxicity in infants due to...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e3181d98e85

    authors: Jou MY,Philipps AF,Kelleher SL,Lönnerdal B

    更新日期:2010-06-01 00:00:00

  • Food allergy as seen by an allergist.

    abstract::The clinical expression of allergic disease is the consequence of a series of complex gene-environment interactions that occur at the materno-fetal interface and throughout infancy, leading to persistence of the Th2 immune response. It has been proposed that atopic eczema is the cutaneous manifestation of a systemic d...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:10.1097/01.mpg.0000338812.59686.6e

    authors: Cox HE

    更新日期:2008-11-01 00:00:00

  • In situ expression of cagA and risk of gastroduodenal disease in Helicobacter pylori-infected children.

    abstract:BACKGROUND AND AIM:Gastroduodenal disease is more common among adults and children with cagA+ Helicobacter pylori infection, but disease severity varies among those infected with cagA+ strains. We examined whether cagA in situ expression can predict disease manifestations among H pylori-infected children. PATIENTS AND...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e3181bab326

    authors: Rick JR,Goldman M,Semino-Mora C,Liu H,Olsen C,Rueda-Pedraza E,Sullivan C,Dubois A

    更新日期:2010-02-01 00:00:00

  • Diagnostic tests in Hirschsprung disease: a systematic review.

    abstract:OBJECTIVE:We conducted a systematic review to determine and compare the diagnostic accuracy of contrast enema (CE), anorectal manometry (ARM) and rectal suction biopsy (RSB) in infants suspected of Hirschsprung disease. DESIGN:This is a systematic review. DATA SOURCES:Articles were identified through electronic searc...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:10.1097/01.mpg.0000214164.90939.92

    authors: de Lorijn F,Kremer LC,Reitsma JB,Benninga MA

    更新日期:2006-05-01 00:00:00

  • Zinc supplementation in acute diarrhea is acceptable, does not interfere with oral rehydration, and reduces the use of other medications: a randomized trial in five countries.

    abstract:OBJECTIVE:Assess the impact of zinc supplementation with locally developed culturally specific educational statements (messages) on oral rehydration solution (ORS) and antibiotics or antidiarrheal use in children with acute watery diarrhea as well as to assess adherence and side effects of zinc. METHODS:This was a ran...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/01.mpg.0000189340.00516.30

    authors: Awasthi S,INCLEN Childnet Zinc Effectiveness for Diarrhea (IC-ZED) Group.

    更新日期:2006-03-01 00:00:00

  • Implementation of a Timed Barium Esophagram Protocol for Assessment of Esophageal Function in Children.

    abstract:OBJECTIVES:Timed barium esophagram (TBE) is a fluoroscopic study that is widely employed as an adjunctive tool for diagnosing esophageal emptying disorders in adults (eg, achalasia, esophagogastric junction outflow obstruction [EGJOO]) and for following response to treatment. We aimed to describe the characteristics an...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002829

    authors: Rosenwald KD,Hayes K,Menard-Katcher C,Belkind-Gerson J

    更新日期:2020-10-01 00:00:00

  • Prevalence and clinical relevance of cagA, vacA, and iceA genotypes of Helicobacter pylori isolated from Slovenian children.

    abstract:BACKGROUND:Although infection with Helicobacter pylori in children mostly induces asymptomatic chronic gastritis, the clinical outcome of H pylori infection is generally unpredictable. To identify the risk subgroup of infected children who can progress toward serious gastrointestinal disease, we assessed the prevalence...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e31818f09f2

    authors: Homan M,Luzar B,Kocjan BJ,Orel R,Mocilnik T,Shrestha M,Kveder M,Poljak M

    更新日期:2009-09-01 00:00:00

  • Shwachman's syndrome: pathomorphosis and long-term outcome.

    abstract:BACKGROUND:Shwachman's syndrome is the second most common cause of inherited/congenital pancreatic insufficiency after cystic fibrosis. The main associated features are usually cyclic neutropenia, metaphyseal dysostosis, and growth retardation. Other organs or functions may be involved in this syndrome, showing a wide ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199909000-00006

    authors: Cipolli M,D'Orazio C,Delmarco A,Marchesini C,Miano A,Mastella G

    更新日期:1999-09-01 00:00:00

  • Effect of calcium and vitamin D supplementation on bone mineral density in children with inflammatory bowel disease.

    abstract:OBJECTIVES:The purpose of this study was to evaluate the effect of calcium and vitamin D2 supplementation on bone mineral density (BMD) in children with inflammatory bowel disease (IBD). PATIENTS AND METHODS:This was an open-label, prospective study conducted over a 12-month period. Seventy-two patients were divided i...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e3180dca0cc

    authors: Benchimol EI,Ward LM,Gallagher JC,Rauch F,Barrowman N,Warren J,Beedle S,Mack DR

    更新日期:2007-11-01 00:00:00

  • Clinical Presentation of Acute Gastroenteritis in Children With Functional Abdominal Pain Disorders.

    abstract::Visceral hypersensitivity and abnormal coping are common in children with functional abdominal pain disorders (FAPDs). Thus, it would be expected that children with visceral hypersensitivity would report more pain if their gut is acutely inflamed. The aim of the study was to compare clinical symptoms and somatization ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章

    doi:10.1097/MPG.0000000000001466

    authors: Saps M,Mintjens S,Pusatcioglu CK,Cohen DM,Sternberg P

    更新日期:2017-08-01 00:00:00

  • Prevalence of metabolic bone disease in children with celiac disease is independent of symptoms at diagnosis.

    abstract:OBJECTIVES:: Given dietary gluten exposure, growing children with celiac disease may experience malabsorption of nutrients, negatively affecting bone health. The purpose of this study was to determine the prevalence of low bone mass in children with celiac disease, according to the presence of symptoms at diagnosis. M...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e31819ca18e

    authors: Turner J,Pellerin G,Mager D

    更新日期:2009-11-01 00:00:00

  • Accurate estimation of energy requirements of young patients.

    abstract::The provision of optimal nutritional care is based on accurate estimations of patients' resting energy expenditure. The latter can be calculated with the use of predictive equations or measured with indirect calorimetry (IC). Owing to their ease of use, mathematical equations have largely replaced IC in clinical pract...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:10.1097/MPG.0000000000000572

    authors: Carpenter A,Pencharz P,Mouzaki M

    更新日期:2015-01-01 00:00:00

  • Ascites complicating ventriculoperitoneal shunts.

    abstract::Ventriculoperitoneal shunts are currently a standard therapy for obstructive hydrocephalus. These shunts are associated with a variety of abdominal complications, one of which is the development of ascites. We report an 11-year-old girl with a ventriculoperitoneal shunt in whom a low-grade peritoneal infection present...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198809000-00028

    authors: Goodman GM,Gourley GR

    更新日期:1988-09-01 00:00:00

  • Etiology of Diarrhea, Nutritional Outcomes, and Novel Intestinal Biomarkers in Tanzanian Infants.

    abstract:OBJECTIVE:Diarrheal diseases are a leading cause of morbidity and mortality worldwide, but the etiology of diarrhea and its relation to nutritional outcomes in resource-limited settings is poorly defined. We sought to determine the etiology of community-acquired diarrhea in Tanzanian infants and to assess the associati...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001323

    authors: Gosselin KB,Aboud S,McDonald CM,Moyo S,Khavari N,Manji K,Kisenge R,Fawzi W,Kellogg M,Tran HQ,Kibiki G,Gratz J,Liu J,Gewirtz A,Houpt E,Duggan C

    更新日期:2017-01-01 00:00:00

  • Prolonged postprandial abdominal pain following Kawasaki syndrome with acute gallbladder hydrops: association with impaired gallbladder emptying.

    abstract::Acute hydrops of the gallbladder is a well-recognized complication of Kawasaki syndrome. We report a case of a child with this syndrome whose gallbladder hydrops slowly resolved after intravenous gamma-globulin therapy. However, he continued to experience postprandial right upper quadrant abdominal pain. Hepatobiliary...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199110000-00013

    authors: Bishop WP,Kao SC

    更新日期:1991-10-01 00:00:00

  • Characteristics of idiosyncratic drug-induced liver injury in children: results from the DILIN prospective study.

    abstract:BACKGROUND:The spectrum and severity of idiosyncratic drug-induced liver injury (DILI) in children are not well established. PATIENTS AND METHODS:The DILIN (Drug-Induced Liver Injury Network) Prospective Study is a longitudinal multicenter study designed to determine the etiologies, risk factors, and outcomes of suspe...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MPG.0b013e31821d6cfd

    authors: Molleston JP,Fontana RJ,Lopez MJ,Kleiner DE,Gu J,Chalasani N,Drug-Induced Liver Injury Network.

    更新日期:2011-08-01 00:00:00

  • Absorption of macronutrients from a high-protein diet in children during convalescence from shigellosis.

    abstract::Absorption of macronutrients and energy intake were determined in 29 children aged 24-59 months, during convalescence from acute shigellosis. A 72 h metabolic balance study was performed to determine the absorption of carbohydrate, fat, and protein. Eighteen children received a high-protein (5 g/kg/day) diet, and 11 c...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章

    doi:10.1097/00005176-199401000-00011

    authors: Kabir I,Malek MA,Mahalanabis D,Rahman MM,Khatun M,Wahed MA,Majid N

    更新日期:1994-01-01 00:00:00

  • Development of the gastrointestinal endoscopy competency assessment tool for pediatric colonoscopy (GiECAT KIDS).

    abstract:OBJECTIVES:Many aspects of pediatric colonoscopy differ from adult practice. To date, there is no validated measure of endoscopic competence for use in pediatrics. Using Delphi methodology, we aimed to determine expert consensus regarding items required on a checklist and global rating scale designed to assess the comp...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000000358

    authors: Walsh CM,Ling SC,Walters TD,Mamula P,Lightdale JR,Carnahan H

    更新日期:2014-10-01 00:00:00

  • Elevated C-reactive protein and spontaneous bacterial peritonitis in children with chronic liver disease and ascites.

    abstract:OBJECTIVES:The aims of this study were to compare laboratory indices of spontaneous bacterial peritonitis (SBP) and noninfected ascites in children with chronic liver disease and to determine the infectious agents involved in SBP. METHODS:The medical records of 90 children with chronic liver disease and ascites studie...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000000177

    authors: Preto-Zamperlini M,Farhat SC,Perondi MB,Pestana AP,Cunha PS,Pugliese RP,Schvartsman C

    更新日期:2014-01-01 00:00:00