Short- and long-term response to and weaning from infliximab therapy in pediatric ulcerative colitis.

Abstract:

OBJECTIVES:We evaluated the response to infliximab in pediatric patients with ulcerative colitis (UC) and their long-term follow-up. We expanded our previous study of 14 patients and furthermore evaluated the success of weaning patients from infliximab. PATIENTS AND METHODS:We reviewed the charts of 27 pediatric patients with UC who were treated with infliximab instead of undergoing a colectomy. Patients with new-onset UC refractory to intravenous steroids for 5 to 10 days and patients with non-steroid-dependent UC with an acute exacerbation were classified as acutely ill (n = 16); patients with chronic steroid-dependent UC were classified as chronically ill (n = 11). The Lichtiger Colitis Activity Index (LCAI) was measured for all patients at baseline and at 1 and 2 months after treatment with infliximab was initiated. Patients were regarded as successfully treated if they remained off steroids and avoided colectomy. RESULTS:The acutely ill group had a mean LCAI score of 11.4 at induction and 0.3 after 2 months. The chronically ill group had a mean LCAI score of 11.2 at induction and 5.5 after 2 months. Treatment with infliximab was successful in 75% of acutely ill patients and in 27% of chronically ill patients. Infliximab was discontinued in 80% of successfully treated patients (83% of acutely ill, 67% of chronically ill). These patients had an average of 10 infusions and a mean follow-up time of 10 months from their last infliximab infusion. CONCLUSIONS:Our results suggest that infliximab is more effective in acutely ill UC patients than in patients with chronic steroid-dependent UC. In addition, some patients treated with infliximab can be weaned from infliximab and maintain remission.

authors

Fanjiang G,Russell GH,Katz AJ

doi

10.1097/MPG.0b013e31802e98d4

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

312-7

issue

3

eissn

0277-2116

issn

1536-4801

pii

00005176-200703000-00004

journal_volume

44

pub_type

杂志文章
  • Early Obesity: Risk Factor for Fatty Liver Disease.

    abstract::Nonalcoholic fatty liver disease (NAFLD), defined as fat accumulation greater than 5% in hepatocytes, may progress to fibrosis or cirrhosis later in life. NAFLD prevalence in adolescents has increased significantly in direct relation with obesity prevalence. Fatty liver has become the most frequent indication for live...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002523

    authors: Cuzmar V,Alberti G,Uauy R,Pereira A,García C,De Barbieri F,Corvalán C,Santos JL,Mericq V,Villarroel L,Gana JC

    更新日期:2020-01-01 00:00:00

  • Acarboxy prothrombin (PIVKA-II) as a marker of hepatoblastoma in infants.

    abstract::We evaluated plasma PIVKA-II (protein induced by vitamin K absence or antagonist-II, acarboxy prothrombin) levels in three infants with hepatoblastoma as a tumor marker. PIVKA-II levels were highly elevated in all three patients. Vitamin K administration, performed in two patients, resulted in only moderate reduction ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198701000-00008

    authors: Motohara K,Endo F,Matsuda I,Iwamasa T

    更新日期:1987-01-01 00:00:00

  • Effects of biliary diversion to the ileum on the in situ disaccharidase activities of duodenal and ileal mucosa in the rat: a study on enzyme kinetics in tissue sections.

    abstract::In order to study the influence of biliary secretions on the in situ kinetic data of brush border disaccharidases in relation to small intestinal villus-crypt architecture, an anastomosis was constructed between the common bile duct, which had been divided before its entrance into the pancreatic head, and the ileum in...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198311000-00019

    authors: Gutschmidt S,Gartemann H

    更新日期:1983-11-01 00:00:00

  • Development and validation of a pediatric IBD knowledge inventory device: the IBD-KID.

    abstract:OBJECTIVES:Questionnaires exist to assess inflammatory bowel disease (IBD)-related knowledge of adults. Owing to wording and content concerns, these were believed to be inappropriate for use in pediatric patients. The aim of this study was to develop a questionnaire to assess disease-related knowledge of pediatric pati...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000000210

    authors: Haaland D,Day AS,Otley A

    更新日期:2014-03-01 00:00:00

  • Liver function in early congenital syphilis: does penicillin cause a deterioration?

    abstract::In this prospective study, neonates with clinical congenital syphilis were investigated to determine if penicillin therapy caused a deterioration in liver function. The relationship between circulating immune complexes and liver involvement was monitored, and the efficacy of steroid therapy as an adjunct in the treatm...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00005176-199104000-00003

    authors: Venter A,Pettifor JM,Duursma J,Pudifin DJ,Smyth A,Becker PJ

    更新日期:1991-04-01 00:00:00

  • Pediatric-onset Chronic Nonspecific Multiple Ulcers of Small Intestine: A Nationwide Survey and Genetic Study in Japan.

    abstract::We performed a Japanese nationwide survey of pediatric-onset chronic nonspecific multiple ulcers of the small intestine between January 2000 and July 2013 in 176 institutions of pediatric surgery or pediatric gastroenterology and clarified the clinical features associated with genetic abnormalities in the Solute Carri...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001321

    authors: Uchida K,Nakajima A,Ushijima K,Ida S,Seki Y,Kakuta F,Abukawa D,Tsukahara H,Maisawa SI,Inoue M,Araki T,Umeno J,Matsumoto T,Taguchi T

    更新日期:2017-04-01 00:00:00

  • Changing patterns of free fatty acids in breast milk during storage.

    abstract::Milk was collected from eight mothers. Total lipid and free fatty acids were determined on collection. The samples were divided into aliquots and stored at 25, 4, or -11 degrees C for 6, 12, 24, or 48 h. Additional samples were stored at -11 or -70 degrees C for 1, 2, 4, 6, or 8 weeks. The effect of temperature, lengt...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198709000-00019

    authors: Lavine M,Clark RM

    更新日期:1987-09-01 00:00:00

  • Analysis of Using the Total White Blood Cell Count to Define Severe New-onset Ulcerative Colitis in Children.

    abstract:OBJECTIVES:The aim of this study was to assess common laboratory tests in identifying severe ulcerative colitis in children at diagnosis. METHODS:A cohort of 427 children 4 to 17 years of age newly diagnosed with ulcerative colitis (UC) was prospectively enrolled. Boosted classification trees were used to characterize...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002797

    authors: Mack DR,Saul B,Boyle B,Griffiths A,Sauer C,Markowitz J,LeLeiko N,Keljo D,Rosh JR,Baker SS,Steiner S,Heyman MB,Patel AS,Baldassano R,Noe J,Rufo P,Kugathasan S,Walters T,Marquis A,Thomas SM,Denson L,Hyams J,PROT

    更新日期:2020-09-01 00:00:00

  • Evaluation of oral rehydration solution by whole-gut perfusion in rats: effect of osmolarity, sodium concentration and resistant starch.

    abstract:BACKGROUND:Reduced osmolarity oral rehydration solution (ORS) improved small bowel absorption of fluid and electrolytes in segmental perfusion in experimental animals; this was borne out in clinical practice. Adding amylase-resistant starch (RS) to ORS is expected to increase colonic fluid absorption. This study used c...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/01.mpg.0000239998.43141.b2

    authors: Subramanya S,Ramakrishna BS,Binder HJ,Farthing MJ,Young GP

    更新日期:2006-11-01 00:00:00

  • Rotavirus A Infections in Community Childhood Diarrhea in the Brazilian Semiarid Region During Postvaccination Era.

    abstract:BACKGROUND:Rotavirus A (RVA) is one of the leading causes of acute gastroenteritis worldwide; however, few studies assessed RVA genetics with community surveillance. OBJECTIVES:This study aimed to investigate clinical data, genetic diversity, and coinfection patterns of RVA infections in children from 2 to 36 months o...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002416

    authors: Pankov RC,Gondim RNDG,Prata MMG,Medeiros PHQS,Veras HN,Santos AKS,Havt A,da Silva MFM,Fumian TM,Miagostovich MP,Leite JPG,Lima AAM

    更新日期:2019-10-01 00:00:00

  • A comparison of oral diazepam versus midazolam, administered with intravenous meperidine, as premedication to sedation for pediatric endoscopy.

    abstract:OBJECTIVES:This study was performed to compare the effects of oral midazolam and oral diazepam, administered with intravenous (IV) meperidine, on pre-procedural, procedural, and post-procedural sedation and recovery in children undergoing diagnostic upper endoscopy. The costs of pre-procedure sedation were compared for...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00005176-200207000-00012

    authors: Martinez JL,Sutters KA,Waite S,Davis J,Medina E,Montano N,Merzel D,Marquez C

    更新日期:2002-07-01 00:00:00

  • Cholestasis associated with total parenteral nutrition.

    abstract::It appears that neonates, especially those with very low birthweights, may be at especially high risk of developing cholestasis associated with total parenteral nutrition (TPN). Within 2 weeks of starting intravenous alimentation, it would appear highly desirable to be able to start at least small enteral feedings to ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:10.1097/00005176-198601000-00004

    authors: Merritt RJ

    更新日期:1986-01-01 00:00:00

  • Vitamin A concentration in the liver decreases with age in patients with cystic fibrosis.

    abstract:BACKGROUND:Vitamin A deficiency is a common manifestation in cystic fibrosis (CF), but high levels of vitamin A in the liver have also been described. High levels of vitamin A in the liver are toxic, while normal levels might be protective against liver damage. In order to investigate whether liver damage in patients w...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199703000-00006

    authors: Lindblad A,Diczfalusy U,Hultcrantz R,Thorell A,Strandvik B

    更新日期:1997-03-01 00:00:00

  • Follow-up after pH-metry and pH impedance in pediatric gastroesophageal reflux disease.

    abstract:OBJECTIVES:It is unclear how diagnostic tests for gastroesophageal reflux disease (GERD) in children relate to the course of symptoms during follow-up. METHODS:During 1 year, all children (ages 0-18 years), who underwent pH-metry and/or pH multichannel intraluminal impedance (MII), were included after written informed...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000000582

    authors: van der Pol RJ,van den Ouweland M,Loots CM,Vandenplas Y,Benninga MA,van Wijk MP

    更新日期:2015-02-01 00:00:00

  • A metabolic bed for collecting excreta in premature infants.

    abstract::A mattress and plastic bed for collection of urine and feces in premature infants housed in isolettes is described. The dimensions of the bed are 65.5 x 34.4 x 13.5 cm. A drainage hole is located 18 cm from the foot of the bed and midway (16.5 cm) from either side. The angle of the depression in the bed for the draina...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199005000-00011

    authors: Kien CL

    更新日期:1990-05-01 00:00:00

  • Effects of intravenously administered safflower oil emulsion on respiratory gas exchange of low-birth-weight infants.

    abstract::Safflower oil emulsion (Liposyn 10%) was infused intravenously to supplement energy intake in five low-birth-weight infants. Respiratory gas exchange was measured before and after the addition of fat emulsion in doses of 1-2 g of fat/kg/day to an intravenous feeding regimen of dextrose and amino acids. The oxygen cons...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198302030-00020

    authors: Bell EF,Weinstein MR,Oh W

    更新日期:1983-01-01 00:00:00

  • Dextranomer hyaluronic acid copolymer effects on gastroesophageal junction.

    abstract:OBJECTIVE:The outcomes of fundoplication for gastroesophageal reflux disease are suboptimal in many children, and alternatives are clearly needed. Dextranomer hyaluronic acid (DxHA) copolymer, an agent with proven efficacy in vesicoureteral reflux, was studied with respect to its effects on the gastroesophageal junctio...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000000259

    authors: Martin K,Emil S,Bernard C,Gaied F,Blumenkrantz M,Laberge JM,Morinville V,Nguyen VH

    更新日期:2014-05-01 00:00:00

  • Hepatitis B virus in the colostra of HBeAg-positive carrier mothers.

    abstract::To investigate the amount of hepatitis B virus (HBV) in colostra of hepatitis B e antigen (HBeAg)-positive carrier mothers and the relationship of HBV amount between colostrum and maternal blood, 50 HBeAg-positive carrier mothers were recruited and studied for hepatitis B surface antigen (HBsAg) titer, HBeAg titer, an...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199308000-00014

    authors: Lin HH,Hsu HY,Chang MH,Chen PJ,Chen DS

    更新日期:1993-08-01 00:00:00

  • Early and Late Factors Impacting Patient and Graft Outcome in Pediatric Liver Transplantation: Summary of an ESPGHAN Monothematic Conference.

    abstract::As pediatric liver transplantation comes of age, experts gathered to discuss current paradigms and define gaps in knowledge warranting research to further improve patient and graft outcomes. Identified areas ripe for collaborative research include understanding the molecular and cellular mechanisms of tolerance and th...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 共识发展会议,杂志文章

    doi:10.1097/MPG.0000000000001564

    authors: McLin VA,Allen U,Boyer O,Bucuvalas J,Colledan M,Cuturi MC,d'Antiga L,Debray D,Dezsofi A,Goyet JV,Dhawan A,Durmaz O,Falk C,Feng S,Fischler B,Franchi-Abella S,Frauca E,Ganschow R,Gottschalk S,Hadzic N,Hierro L,Hor

    更新日期:2017-09-01 00:00:00

  • Assessment of preclinical vitamin A deficiency in children with persistent diarrhea.

    abstract::To explore the relationship between vitamin A deficiency and persistent diarrhea among young children, we studied the vitamin A status of 23 children greater than 5 years of age with persistent diarrhea by performing conjunctival impression cytology (CIC) and the relative dose-response test (RDR) as a measure of liver...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199108000-00009

    authors: Usha N,Sankaranarayanan A,Walia BN,Ganguly NK

    更新日期:1991-08-01 00:00:00

  • In vivo intestinal zinc transport in rats: normal and growth retarded.

    abstract::We compared the in vivo transport of zinc in segments of jejunum, ileum, and colon of 2-week-old (suckling) and 6-week-old (adolescent) rats. In normal rats, net absorption and lumen to mucosa flux of zinc, normalized for differences in size of the intestine (mumol/h/g dry weight) were significantly greater in all per...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198201010-00020

    authors: Meneely R,Ghishan FK

    更新日期:1982-01-01 00:00:00

  • Developmental changes in the intra-acinar distribution of succinate dehydrogenase, glutamate dehydrogenase, glucose-6-phosphatase, and NADPH dehydrogenase in the rat liver.

    abstract::Hepatocytes differ in their metabolism depending on their position in the liver acinus. To assess how such specialization changes during development, we used quantitative cytochemistry to measure succinate dehydrogenase (SDH), glutamate dehydrogenase (GDH), glucose-6-phosphatase (G6P), and NADPH dehydrogenase (ND) act...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198905000-00017

    authors: Sokal EM,Trivedi P,Portmann B,Mowat AP

    更新日期:1989-05-01 00:00:00

  • Acarboxy prothrombin in cord plasma from normal neonates.

    abstract::Acarboxy prothrombin was detected in the plasma of 48 of 128 umbilical cord plasma samples and in all of 65 patients receiving coumadin. None was found in 20 normal adults. Although the prevalence was the same in blacks, whites, and neonates of mixed origin, levels were significantly higher in blacks. There was a nega...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198406000-00025

    authors: Atkinson PM,Bradlow BA,Moulineaux JD,Walker NP

    更新日期:1984-06-01 00:00:00

  • Changes in Proteases, Antiproteases, and Bioactive Proteins From Mother's Breast Milk to the Premature Infant Stomach.

    abstract:OBJECTIVE:Our previous studies suggested that human milk proteases begin to hydrolyze proteins in the mammary gland and continue within the term infant' stomach. No research has measured milk protease and pepsin activity in the gastric aspirates of preterm infants after human milk feeding. This study investigated how t...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001719

    authors: Demers-Mathieu V,Nielsen SD,Underwood MA,Borghese R,Dallas DC

    更新日期:2018-02-01 00:00:00

  • Growth Pattern in Paediatric Crohn Disease Is Related to Inflammatory Status.

    abstract:OBJECTIVES:The respective role of disease activity and steroid therapy in growth impairment in paediatric-onset Crohn disease (CD) is still debated. Our aim was to investigate whether the growth pattern of children with CD was correlated with the inflammatory status during the disease course, regardless the cumulative ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MPG.0000000000001177

    authors: Ley D,Duhamel A,Behal H,Vasseur F,Sarter H,Michaud L,Gower-Rousseau C,Turck D

    更新日期:2016-12-01 00:00:00

  • Clinical response to short-term nasogastric feeding in infants with gastroesophageal reflux and growth failure.

    abstract::When conventional treatment with upright positioning and thickened feedings fails to control vomiting associated with gastroesophageal reflux (GER) of infancy, malnutrition and growth failure may result. If this occurs, fundoplication is usually recommended. In this study, 12 infants with growth failure associated wit...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198302010-00007

    authors: Ferry GD,Selby M,Pietro TJ

    更新日期:1983-01-01 00:00:00

  • Doxycycline-induced hemorrhagic esophagitis: a pediatric case.

    abstract::Esophagitis induced by medications has been recognized in adults but rarely in children. A child with hemorrhagic esophagitis resulting from taking doxycycline tablets for treatment is described and the pathophysiology of this condition is discussed. In pediatric cases treated by tablets or capsules, the possibility o...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198809000-00023

    authors: Kato S,Kobayashi M,Sato H,Saito Y,Komatsu K,Harada Y

    更新日期:1988-09-01 00:00:00

  • Intact Regulatory T-Cell Function but Defective Generation of IL-17A-Producing CD4+ T Cells in XIAP Deficiency.

    abstract:OBJECTIVE:X-linked inhibitor of apoptosis (xIAP) deficiency is a primary immune deficiency disorder associated with hemophagocytic lymphohistiocytosis. About 17% of xIAP-deficient patients present with very early onset severe colitis with high mortality. We hypothesized that xIAP deficiency leads to defective generatio...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001122

    authors: Gurram B,Hammelev E,Syverson G,Haribhai D,Yan K,Simpson P,Salzman N,Verbsky JW

    更新日期:2016-08-01 00:00:00

  • Reactive nitrogen species modulate the effects of rhein, an active component of senna laxatives, on human epithelium in vitro.

    abstract:BACKGROUND:Senna laxatives are used worldwide. However, their misuse can lead to chronic mucosal inflammation with the accumulation of pigment-laden leukocytes and may cause colon cells to undergo apoptosis. This study explores the mechanisms by which rhein, an active component of senna, acts on a human intestinal cell...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-200205000-00011

    authors: Raimondi F,Santoro P,Maiuri L,Londei M,Annunziata S,Ciccimarra F,Rubino A

    更新日期:2002-05-01 00:00:00

  • Impact of COVID-19 on Pediatric Gastroenterology Fellow Training in North America.

    abstract:BACKGROUND:The COVID-19 pandemic has drastically changed healthcare systems and training around the world. The Training Committee of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition sought to understand how COVID-19 has affected pediatric gastroenterology fellowship training. METHODS...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002768

    authors: Mallon D,Pohl JF,Phatak UP,Fernandes M,Rosen JM,Lusman SS,Nylund CM,Jump CS,Solomon AB,Srinath A,Singer A,Harb R,Rodriguez-Baez N,Whitfield Van Buren KL,Koyfman S,Bhatt R,Soler-Rodriguez DM,Sivagnanam M,Lee CK,NASPG

    更新日期:2020-07-01 00:00:00