Acarboxy prothrombin (PIVKA-II) as a marker of hepatoblastoma in infants.

Abstract:

:We evaluated plasma PIVKA-II (protein induced by vitamin K absence or antagonist-II, acarboxy prothrombin) levels in three infants with hepatoblastoma as a tumor marker. PIVKA-II levels were highly elevated in all three patients. Vitamin K administration, performed in two patients, resulted in only moderate reduction of PIVKA-II levels. Chemotherapy against tumor cells reduced the PIVKA-II levels without exception. Immunohistochemical study of the liver tissue indicated the presence of PIVKA-II in the hepatoblastoma cell. These findings suggest that elevated PIVKA-II in these patients was not due to nutritional vitamin K deficiency, but to excess production of tumor cells. A measurement of plasma PIVKA-II may be useful as a new marker of hepatoblastoma.

authors

Motohara K,Endo F,Matsuda I,Iwamasa T

doi

10.1097/00005176-198701000-00008

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

42-5

issue

1

eissn

0277-2116

issn

1536-4801

journal_volume

6

pub_type

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