Histologic coagulative tumor necrosis as a prognostic indicator of renal cell carcinoma aggressiveness.

abstract：:Although training programs exist in both medical oncology and geriatrics (approved by the American Board of Internal Medicine), neither is adequate to ensure an appropriate supply of physicians to assume a leadership role in the treatment of the increasing number of geriatric patients who have or will develop a malign...

journal_title：Cancer

authors： Bennett JM,Sahasrabudhe DM,Hall WJ

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND:Tropisetron (ICS 205-930) antagonizes the serotonin type 3 receptor and has antiemetic activity in animals given cisplatin. Its mean serum half-life in 11.1 hours. METHODS:In this dose-ranging trial, 22 patients undergoing anti-cancer chemotherapy received 24 courses of a single intravenous infusion of trop...

journal_title：Cancer

authors： Pisters KM,Kris MG,Tyson LB,Clark RA,Gralla RJ

更新日期：1993-01-01 00:00:00

abstract：:Hereditary cancer represents approximately 5-10% of the total cancer burden and may account for 60,000 to 120,000 new cancer occurrences this year in the United States. New developments in molecular genetics and the cloning of cancer-prone genes have intensely fueled interest in dealing with hereditary forms of cancer...

journal_title：Cancer

authors： Lynch HT,Watson P,Shaw TG,Lynch JF,Harty AE,Franklin BA,Kapler CR,Tinley ST,Liu B

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:Micropapillary serous carcinoma (MPSC), a recently described entity, is an ovarian tumor with a distinctive histologic architecture that lacks a destructive infiltrative growth pattern and behaves like a low-grade neoplasm. The purpose of this study was to determine if specific cytomorphologic features were ...

journal_title：Cancer

authors： Alli PM,Ali SZ

更新日期：2002-06-25 00:00:00

abstract：:Elective irradiation of sites of potential occult tumor spread is often part of a patient's radiation therapy program. The required radiation dose (D) depends on the probability that occult disease exists (P(occ)), the number of sites at risk (A), the number of tumor clonogens present (Ni), their radiation sensitivity...

journal_title：Cancer

authors： Marks LB

更新日期：1990-12-15 00:00:00

abstract：:Two unusual cases of angioimmunoblastic lymphadenopathy with dysproteinemia (AILD), with progression to immunoblastic lymphoma (IL) and prominent gastric involvement are presented, and detailed immunohistologic studies described. In one case, Bence Jones proteinuria of the kappa type was observed during the course of ...

journal_title：Cancer

authors： Bauer TW,Mendelsohn G,Humphrey RL,Mann RB

更新日期：1982-11-15 00:00:00

abstract：:Five hundred forty three adult patients with acute leukemia were entered on the study designed to: (1) test efficacy of vincristine and prednisone used as primary drug therapy in patients with good prognosis as judged by a circulating blast cell count less than 30,000 cm2; (2) investigate the use of either simultaneou...

journal_title：Cancer

authors： McCredie KB,Gehan EA,Freireich EJ,Hewlett JS,Coltman CA Jr,Hussein KK,Balcerzak SP,Chen TT

更新日期：1983-09-15 00:00:00

abstract：:The circulating levels of four tumor- or trophoblast-associated antigens were measured by specific radioimmunoassays in 11 patients with gestational choriocarcinoma. The estimations were carried out at the time when the urinary gonadotropin (hCG) excretion was low or negligible. Gonadotropin, measured as the hCG beta-...

journal_title：Cancer

authors： Seppälä M,Rutanen EM,Ranta T,Aho I,Nieminen U,Unnérus HA,Saksela E

更新日期：1976-11-01 00:00:00

abstract：:In order to determine if there are morphologically identifiable characteristics between malignant cells obtained from a primary cancer and its metastasis the nuclear diameter was used as an indicator of the degree of malignancy, since there is good correlation between nuclear size, DNA content, and chromosome numbers....

journal_title：Cancer

authors： Zajdela A,Asselain B,Ghossein NA

更新日期：1985-10-01 00:00:00

abstract：:Staining with Concanavalin agglutinin (Con A) reveals a far greater number of macrophage-histiocytes (M-H) in paraffin sections than any other staining method. With Con A staining, the shapes of stromal M-H are clearly visualized, thus enabling a study of their morphologic variations. Con A staining patterns were also...

journal_title：Cancer

authors： Ree HJ

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND:Uveal melanomas of the choroid and ciliary body are aggressive tumors causing the death of approximately 50% of patients. In contrast, iris melanomas only infrequently metastasize; why these differences exist is not known. The local environment can regulate cancer growth and development, and it is probable t...

journal_title：Cancer

authors： Canovas D,Rennie IG,Nichols CE,Sisley K

更新日期：2008-04-15 00:00:00

abstract：:The long-term cancer specific survival based on individual follow-up and analysis of prospectively collected data from 1061 patients undergoing resection for carcinoma of the rectum is presented. All patients were operated on and managed by one surgeon. Survival data for 978 cases were analyzed according to the method...

journal_title：Cancer

authors： Pihl E,Hughes ES,McDermott FT,Milne BJ,Korner JM,Price AB

更新日期：1980-06-01 00:00:00

abstract：:The short term addition of nandrolone decanoate to combination chemotherapy given to patients with unresectable non-small cell lung cancer was evaluated in a randomized, prospective trial. Patients were treated with doxorubicin 50 mg/M2 intravenously, cyclophosphamide 300 mg/M2 intravenously, CCNU 50 mg/M2 orally, vin...

journal_title：Cancer

authors： Chlebowski RT,Herrold J,Ali I,Oktay E,Chlebowski JS,Ponce AT,Heber D,Block JB

更新日期：1986-07-01 00:00:00

abstract：:The cellular DNA content in colorectal biopsies from 51 patients with chronic ulcerative colitis has been studied with flow-cytometric technique. The DNA pattern has been related to the duration of the disease, and to histopathology. Aneuploid cell lines were found in eight patients, two of which had histopathological...

journal_title：Cancer

authors： Hammarberg C,Slezak P,Tribukait B

更新日期：1984-01-15 00:00:00

abstract：BACKGROUND:Prostate-specific antigen (PSA) screening for prostate cancer has high risks of overdiagnosis, particularly among older men, and reports from screening trials indicate that it saves few lives after 11 to 13 years of follow-up. New clinical guidelines recommend against PSA screening for all men or for men age...

journal_title：Cancer

authors： Gulati R,Tsodikov A,Etzioni R,Hunter-Merrill RA,Gore JL,Mariotto AB,Cooperberg MR

更新日期：2014-11-15 00:00:00

abstract：BACKGROUND:Prior literature has suggested synergy between immune checkpoint therapy (ICT) and radiotherapy (RT) for the treatment of brain metastases (BrM), but to the authors' knowledge the optimal timing of therapy to maximize this synergy is unclear. METHODS:A total of 199 patients with melanoma and non-small cell ...

journal_title：Cancer

authors： Qian JM,Martin AM,Martin K,Hammoudeh L,Catalano PJ,Hodi FS,Cagney DN,Haas-Kogan DA,Schoenfeld JD,Aizer AA

更新日期：2020-12-15 00:00:00

abstract：BACKGROUND:Patients with invasive breast carcinoma who are ages 35-40 years or younger at the time of diagnosis have been found in several studies to have worse prognosis and higher local failure rates after breast-conserving therapy (BCT) compared with older patients. However, it is uncertain whether specific clinical...

journal_title：Cancer

authors： Zhou P,Recht A

更新日期：2004-09-15 00:00:00

abstract：:A 26-year-old man with erythroleukemia was found to have circulating micromegakaryocytes . Megakaryocytic features were defined by morphologic and cytochemical studies using light and electron microscopy with platelet-megakaryocyte peroxidase staining. This appears to be the first reported instance of erythroleukemia ...

journal_title：Cancer

authors： Yamauchi K,Miyauchi J,Nagao T

更新日期：1984-06-15 00:00:00

abstract：BACKGROUND:Gastric carcinoids are uncommon, and are unlike carcinoids at other gastrointestinal sites, clinically and pathologically. METHODS:The authors studied specimens from 104 patients with gastric carcinoid, with study emphasis being placed on pathologic features, immunohistochemistry, clinical associations, and...

journal_title：Cancer

authors： Thomas RM,Baybick JH,Elsayed AM,Sobin LH

更新日期：1994-04-15 00:00:00

abstract：:This study examines the interrelationships of depth of penetration, tumor size, and the number of positive nodes in Dukes C colorectal cancer. The results indicated that depth of tumor penetration was related to both tumor size and the number of positive regional lymph nodes. Tumors with positive nodes which failed to...

journal_title：Cancer

authors： Wolmark N,Fisher ER,Wieand HS,Fisher B

更新日期：1984-06-15 00:00:00

abstract：:Cystic medullary carcinoma of the breast is unusual. This report describes five patients with medullary carcinoma who presented clinically with a breast cyst. Fine-needle aspiration biopsy (NAB) was performed as part of the initial physical examination and the retrieved cyst fluid was examined cytologically. Four of t...

journal_title：Cancer

authors： Howell LP,Kline TS

更新日期：1990-01-15 00:00:00

abstract：BACKGROUND:Both genetic and epigenetic changes in nonsmall cell lung cancer (NSCLC) are known to be a common event. METHODS:Mutations in the epidermal growth factor receptor gene (EGFR), HER-2, and KRAS and the methylation profile of 9 genes for NSCLC were analyzed and correlated with clinical and histologic data. RE...

journal_title：Cancer

authors： Suzuki M,Shigematsu H,Iizasa T,Hiroshima K,Nakatani Y,Minna JD,Gazdar AF,Fujisawa T

更新日期：2006-05-15 00:00:00

abstract：BACKGROUND:The unknown etiology of endometrioid carcinomas of the ovary and the relatively high frequency of a concomitant carcinoma of the endometrium in these patients warrants study of such tumors. The aim of this study was to identify the genetic alterations involved in endometrioid ovarian cancer development, and ...

journal_title：Cancer

authors： Shenson DL,Gallion HH,Powell DE,Pieretti M

更新日期：1995-08-15 00:00:00

abstract：:Merkel cell carcinoma (MCC) is a relatively rare cutaneous malignancy that occurs predominantly in the older white population. The incidence of MCC appears to have tripled during the past 20 years; an increase that is likely to continue because of the growing number of older Americans. The pathogenesis of MCC remains ...

journal_title：Cancer

authors： Bichakjian CK,Lowe L,Lao CD,Sandler HM,Bradford CR,Johnson TM,Wong SL

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Ovarian serous tumors of low malignant potential (STLMP) occasionally progress; a small percentage of patients die of the tumor. There is no known way to predict which tumors will progress. METHODS:Forty STLMP were analyzed by DNA flow cytometry and compared with 26 serous carcinomas. RESULTS:Forty percent...

journal_title：Cancer

authors： Seidman JD,Norris HJ,Griffin JL,Hitchcock CL

更新日期：1993-06-15 00:00:00

abstract：BACKGROUND:National Cancer Institute (NCI)/National Comprehensive Cancer Network (NCCN)-designated cancer centers (CCs) offer patients state-of-the-art treatment, but their impact on multiple myeloma (MM) patient outcomes has not been evaluated. METHODS:Adult MM patients diagnosed between 1973 and 2011 were identified...

journal_title：Cancer

authors： Ailawadhi S,Advani P,Yang D,Ghosh R,Swaika A,Roy V,Foran J,Colon-Otero G,Chanan-Khan A

更新日期：2016-02-15 00:00:00

abstract：BACKGROUND:The staging system for non-small cell lung cancer (NSCLC) does not consider tumor burden or number of metastatic sites, although oligometastases are more favorable. METHODS:Using log-rank testing, the authors analyzed overall survival (OS) in 1284 patients newly presenting with metastatic NSCLC by number of...

journal_title：Cancer

authors： Oh Y,Taylor S,Bekele BN,Debnam JM,Allen PK,Suki D,Sawaya R,Komaki R,Stewart DJ,Karp DD

更新日期：2009-07-01 00:00:00

abstract：:Tumor weight, carcass weight, nitrogen balance, energy balance, resting energy expenditure (REE), and activity energy expenditure (AEE) were measured in normal Fischer 344 rats, free-feeding Fischer 344 rats with methylcholanthrene-induced sarcoma (TB-FF), and similar tumor-bearing rats supported with total parenteral...

journal_title：Cancer

authors： Popp MB,Brennan MF,Morrison SD

更新日期：1982-03-15 00:00:00

abstract：:The objective of this study was to evaluate the sensitivity of two methods for determining bone marrow involvement with non-Hodgkin's lymphoma. These methods were histologic review of bone marrow aspirates, and clot sections versus in vitro growth of lymphoma colonies on soft agar. Forty-two bone marrow aspirates were...

journal_title：Cancer

authors： Smith SD,Kisker S,Bush L,Trueworthy RC

更新日期：1984-04-15 00:00:00

abstract：BACKGROUND:This Phase III trial was performed to compare the roles of oral etoposide and intravenous (i.v.) vinblastine in the treatment of Mediterranean Kaposi's Sarcoma (MEKS) in elderly patients with severe disease (Stages II, Ac/B, III, and IV). PATIENTS AND METHODS:Sixty-five patients were randomized to receive e...

journal_title：Cancer

authors： Brambilla L,Labianca R,Boneschi V,Fossati S,Dallavalle G,Finzi AF,Luporini G

更新日期：1994-11-15 00:00:00